Correction: Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings

“…For instance, correlations of schizophrenia versus control deep brain structure effect size profiles based on three independent reports -the ENIGMA Schizophrenia Working Group, 51 Cognitive Genetics Collaborative Research Organization (COCORO), 86,87 and a third independent cohort 11 -showed correlations of about 0.98; for review see. 88 Similarly, case-control fractional anisotropy effect sizes based on ENIGMA 47,73,74 and COCORO 89 r = 0.47); for review see. 32 These findings suggest that large metaand mega-analyses can generate reproducible structural image profiles for neuropsychiatric disorders.…”

“…For their initial studies, the SZ, BD, and MDD groups used the meta‐analytic method, where each site analyses their own data, and a leading site conducts the meta‐analysis based on each site's results. The 22q11DS group was able to conduct mega‐analyses, which pooled data from all sites for combined analyses while statistically adjusting for effects of scanner (site) 46–49 . Both analysis approaches, also referred to as two‐stage and one‐stage meta‐analyses in the statistical literature, 50 have advantages and disadvantages; for a review and a comparison, see Schmaal et al 29 …”

“…Favre and colleagues reported on a mega‐ and meta‐analysis of white matter (WM) abnormalities based on diffusion tensor imaging (DTI) data from 1482 individuals with bipolar disorder (BD) and 1551 healthy controls from 26 samples worldwide 47 . The mega‐analysis found significantly lower FA in individuals with BD compared to healthy controls in 29 out of 43 JHU atlas ROIs with the largest effect sizes in the whole corpus callosum (CC), followed by the body and genu of the CC and the bilateral cingulum.…”

“…The 22q11DS group was able to conduct mega-analyses, which pooled data from all sites for combined analyses while statistically adjusting for effects of scanner (site). [46][47][48][49] Both analysis approaches, also referred to as two-stage and one-stage meta-analyses in the statistical literature, 50 have advantages and disadvantages; for a review and a comparison, see Schmaal et al 29 This review largely follows the chronological order in which the groups have produced their findings, starting with findings on subcortical brain structures, followed by cortical thickness and surface area, diffusion tensor imaging, and the most recent subcortical structure shape analysis findings; details of reported studies are summarized in Table 1. After reviewing the findings, cross disorder effect size profiles and cross disorder effect size correlations are compared.…”

Age‐related structural and functional variations in 5,967 individuals across the adult lifespan

“…Fourth, the resolution of the fMRI images is sub‐optimal (3.75 × 3.75 × 4.55 mm) compared to the newer multi‐band sequences (2–3 mm isotropic). In addition, there are some existing large N datasets, for example, ENIGMA (Favre et al, ; Hoogman et al, ; van Velzen et al, ), 10 K in 1 day (van den Heuvel et al, ) and morphometric similarity networks (Seidlitz et al, ), which introduce several new network features that can be used to investigate age‐related variations in both healthy as well as disease.…”