Correction: Whole Genome Comparisons Suggest Random Distribution of Mycobacterium ulcerans Genotypes in a Buruli Ulcer Endemic Region of Ghana

Ablordey, Anthony; Vandelannoote, Koen; Frimpong, Isaac A.; Ahortor, Evans K.; Amissah, Nana Ama; Eddyani, Miriam; Durnez, Lies; Portaels, Françoise; Jong, Bouke C. de; Leirs, Herwig; Porter, Jessica L.; Mangas, Kirstie M.; Buultjens, Andrew H.; Seemann, Torsten; Tobias, Nicholas J.; Stinear, Timothy P.

doi:10.1371/journal.pntd.0003798

Cited by 2 publications

(2 citation statements)

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“…In the area of M. ulcerans research, utility of whole-genome sequencing has been studied from an ecologic and epidemiologic perspective. Studies indicate a strong relationship between the genotype of an isolate and the geographic origin of disease at a national and regional level ( 19 – 21 ). However, there is no information available on the relationship between the genotype of an isolate and the clinical severity of disease in affected patients.…”

Section: Discussionmentioning

confidence: 99%

Increased Severity and Spread ofMycobacterium ulcerans, Southeastern Australia

Tai¹,

Athan²,

Friedman³

et al. 2018

Emerg. Infect. Dis.

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Reported cases of Mycobacterium ulcerans disease (Buruli ulcer) have been increasing in southeastern Australia and spreading into new geographic areas. We analyzed 426 cases of M. ulcerans disease during January 1998–May 2017 in the established disease-endemic region of the Bellarine Peninsula and the emerging endemic region of the Mornington Peninsula. A total of 20.4% of cases patients had severe disease. Over time, there has been an increase in the number of cases managed per year and the proportion associated with severe disease. Risk factors associated with severe disease included age, time period (range of years of diagnosis), and location of lesions over a joint. We highlight the changing epidemiology and pathogenicity of M. ulcerans disease in Australia. Further research, including genomic studies of emergent strains with increased pathogenicity, is urgently needed to improve the understanding of this disease to facilitate implementation of effective public health measures to halt its spread.

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Section: Discussionmentioning

confidence: 99%

Increased Severity and Spread ofMycobacterium ulcerans, Southeastern Australia

Tai¹,

Athan²,

Friedman³

et al. 2018

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

“…Additionally, it cannot distinguish between MU strains from patients and the environment. A more appropriate approach would be whole-genome sequencing [145] , [146] , [147] .…”

Section: Discussionmentioning

confidence: 99%