Correction: Warzecha, Z., et al. Therapeutic Effect of Low Doses of Acenocoumarol in the Course of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats. Int. J. Mol. Sci. 2017, 18, 882

Warzecha, Zygmunt; Sendur, Paweł; Ceranowicz, Piotr; Cieszkowski, Jakub; Dembiński, Marcin; Sendur, R; Bonior, Joanna; Jaworek, Jolanta; Ambroży, Tadeusz; Olszanecki, Rafał; Kuśnierz-Cabała, Beata; Kaczmarzyk, Tomasz; Tomaszewska, Romana; Dembiński, Artur

doi:10.3390/ijms20123086

Cited by 2 publications

(1 citation statement)

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“…Group II (ISO): Animals were treated with ISO only (85 mg/kg BW, subcutaneously) for two consecutive days (on Days 6 and 7). [6] Group III (ISO + Ace): Animals were pre-cotreated with Acenocoumarol (150 µg/kg BW) [29] by gastric gavage route for 7 days and treated with ISO only (85 mg/kg BW, subcutaneously) on Days 6 and 7.…”

Section: Experimental Designmentioning

confidence: 99%

Cardiopreventive capacity of a novel (E)‐Nʹ‐(1‐(7‐methoxy‐2‐oxo‐2H‐chromen‐3‐yl) ethylidene)‐4‐methylbenzenesulfonohydrazide against isoproterenol‐induced myocardial infarction by moderating biochemical, oxidative stress, and histological parameters

Khdhiri

Mnafgui

Ncir

et al. 2021

J Biochem & Molecular Tox

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This study is carried out to assess the cardiopreventive effect of (E)-N'-(1-(7methoxy-2-oxo-2H-chromen-3-yl) ethylidene)-4-methylbenzenesulfonohydrazide or SHC, a novel synthesized coumarin, against myocardial infarction induced by isoproterenol (ISO). The SHC compound was identified and characterized by spectral methods (infrared, 1 H NMR [nuclear magnetic resonance], 13 C NMR, Nuclear Overhauser Effect Spectroscopy, and high-resolution mass spectroscopy). Male Wistar rats were divided into four groups: Control, ISO (rats were injected subcutaneously by 85 mg/kg body weight [BW] of isoproterenol at Days 6 and 7 of the experience), ISO + SHC (150 µg/kg BW, orally for 7 days) and ISO + acenocoumarol (150 µg/kg BW, orally for 7 days). Results showed that ISO induced a remarkable alteration of electrocardiogram (ECG) pattern and increases of plasma cardiac troponin T, creatine kinase-MB, total cholesterol, triglycerides, low-density lipoprotein-cholesterol, lactate dehydrogenase, aspartate transaminase, and malondialdehyde. In addition, ISO reduced the high-density lipoproteincholesterol content and the activities of superoxide dismutase and glutathione peroxidase, with the induction of myocardial necrosis. However, SHC administration revealed a significant decrease in cardiac dysfunction markers, restored normal ECG pattern, as well as improving lipids parameters. Moreover, SHC treatment remarkably alleviated the cardiac oxidative stress and the myocardial remodeling process. Overall, the SHC offers good protection from acute myocardial infarction through the antioxidant capacity.

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Section: Experimental Designmentioning

confidence: 99%

Cardiopreventive capacity of a novel (E)‐Nʹ‐(1‐(7‐methoxy‐2‐oxo‐2H‐chromen‐3‐yl) ethylidene)‐4‐methylbenzenesulfonohydrazide against isoproterenol‐induced myocardial infarction by moderating biochemical, oxidative stress, and histological parameters

Khdhiri

Mnafgui

Ncir

et al. 2021

J Biochem & Molecular Tox

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Protective effect of bergapten in acetic acid-induced colitis in rats

Adakudugu

Ameyaw

Obese

et al. 2020

Heliyon

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Bergapten (5-methoxysporalen) is a furanocoumarin extracted from several species of citrus and bergamot oil. Bergamot essential oil is used traditionally in the management of inflammatory conditions. Previous studies on bergapten have explored mainly its in vitro anti-inflammatory activities which include suppression of the expression and release of pro-inflammatory cytokines such as TNF-α and interleukins as well as prostaglandins. Bergapten enhances the clearance of neutrophils and macrophages from the site of inflammation and reduces oxidative stress by inhibition of reactive oxygen species (ROS). Bergapten was assessed for its anti-inflammatory properties in acetic acid-induced colitis. Animals were obtained and randomly placed in six (6) groups (n = 5) after acclimatization. Colitis was induced by rectal administration using 4% v / v acetic acid in Sprague Dawley rats after pre-treatment for 5 days. Bergapten was administered at doses of 3, 10, and 30 mg kg −1 p.o . while the control group received saline 5 mL kg −1 p.o. and the standard drug employed was sulphasalazine at a dose of 500 mg kg −1 . Assessments made for colon-weight-to-length ratio, colonic injury, and mucosal mast cell degranulation. There were reduced colon-weight-to-length ratios in animals treated with bergapten which was significant ( p < 0.5 ) for doses 10 and 30 mg kg −1 compared to the disease control group Both macroscopic and microscopic damage were reduced as well, with a lesser percentage of degranulated mast cells. Macroscopic damage was reduced for bergapten at doses 10 and 30 mg kg −1 significantly at p < 0.5 and p < 0.001, respectively. Similarly, microscopic damage was reduced at p < 0.01 and p < 0.001 respectively for bergapten 10 and 30 mg kg −1 . The reduction of degranulation by bergapten was significant at p < 0.001 . There was generally reduced damage at inflammatory sites as well as decreased infiltration of inflammatory cells. Overall, bergapten reduces inflammation in acetic acid-induced colitis.

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Correction: Warzecha, Z., et al. Therapeutic Effect of Low Doses of Acenocoumarol in the Course of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats. Int. J. Mol. Sci. 2017, 18, 882

Abstract: We would like to submit this correction to our published paper [...]

Cited by 2 publications

References 1 publication

Cardiopreventive capacity of a novel (E)‐Nʹ‐(1‐(7‐methoxy‐2‐oxo‐2H‐chromen‐3‐yl) ethylidene)‐4‐methylbenzenesulfonohydrazide against isoproterenol‐induced myocardial infarction by moderating biochemical, oxidative stress, and histological parameters

Cardiopreventive capacity of a novel (E)‐Nʹ‐(1‐(7‐methoxy‐2‐oxo‐2H‐chromen‐3‐yl) ethylidene)‐4‐methylbenzenesulfonohydrazide against isoproterenol‐induced myocardial infarction by moderating biochemical, oxidative stress, and histological parameters

Protective effect of bergapten in acetic acid-induced colitis in rats

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