Correction: Utility of NT-proBNP for Identifying LV Failure in Patients with Acute Exacerbation of Chronic Bronchitis

Wang, Qingping; Cao, Xiaozhi; Wang, Xuedong; Gu, Jiande; Luo, Wen; Mao, Liming; Shan, Ping-nan; Tang, Anliu

doi:10.1371/annotation/b034b49e-ac17-4bd5-9ed8-42b51aca5e73

Cited by 14 publications

(1 citation statement)

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“…For years, NT‐proBNP has been believed to be an established risk marker for HF. Our analysis indicated that the predictive power of NRON is comparable to that of NT‐proBNP: The reported value of AUC is 0.844 for NT‐proBNP , and the value for NRON was 0.865. By comparison, the AUC value for MHRT is lower (0.702); yet, it still falls into the ‘good’ category for clinical applications according to the guide for classifying the accuracy of a diagnostic test with the traditional academic point system (0.9–1.0 excellent; 0.8–0.9 very good; 0.7–0.8 good; 0.6–0.7 sufficient; 0.5–0.6 bad; < 0.5 test not useful) .…”

Section: Discussionmentioning

confidence: 65%

Circulating long non‐coding RNAs NRON and MHRT as novel predictive biomarkers of heart failure

Xuan

Sun

Zhang

et al. 2017

J Cellular Molecular Medi

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This study sought to evaluate the potential of circulating long non‐coding RNAs (lncRNAs) as biomarkers for heart failure (HF). We measured the circulating levels of 13 individual lncRNAs which are known to be relevant to cardiovascular disease in the plasma samples from 72 HF patients and 60 non‐HF control participants using real‐time reverse transcription‐polymerase chain reaction (real‐time RT‐PCR) methods. We found that out of the 13 lncRNAs tested, non‐coding repressor of NFAT (NRON) and myosin heavy‐chain‐associated RNA transcripts (MHRT) had significantly higher plasma levels in HF than in non‐HF subjects: 3.17 ± 0.30 versus 1.0 ± 0.07 for NRON (P < 0.0001) and 1.66 ± 0.14 versus 1.0 ± 0.12 for MHRT (P < 0.0001). The area under the ROC curve was 0.865 for NRON and 0.702 for MHRT. Univariate and multivariate analyses identified NRON and MHRT as independent predictors for HF. Spearman's rank correlation analysis showed that NRON was negatively correlated with HDL and positively correlated with LDH, whereas MHRT was positively correlated with AST and LDH. Hence, elevation of circulating NRON and MHRT predicts HF and may be considered as novel biomarkers of HF.

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Section: Discussionmentioning

confidence: 65%