Correction: Transcriptome of the synganglion in the tick Ixodes ricinus and evolution of the cys-loop ligand-gated ion channel family in ticks

Rispe, C.; Hervet, Caroline; Cotte, Nathalie; Daveu, Romain; Labadie, Karine; Noël, Benjamin; Aury, Jean‐Marc; Thany, Steeve Hervé; Taillebois, Emiliane; Cartereau, Alison; Mauf, Anaïs Le; Charvet, Claude; Auger, Clément; Courtot, Elise; Neveu, Cédric; Plantard, Olivier

doi:10.1186/s12864-022-08740-0

Cited by 2 publications

(1 citation statement)

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“…The Voltage-gated Na+ and K+ channels are responsible for the propagation of electrical signals and generation of action potentials in neurons (Yu and Catterall, 2003). In ticks, synganglion, fused masses of nerve tissue (Rispe et al, 2022) is a key target for the existing acaricides (Roma et al, 2014). Pyrethroids are broad-spectrum acaricides and their main mechanism of action is altering the function of voltage-sensitive sodium channels in nerve membranes (Sattelle and Yamamoto, 1988;Narahashi, 1996;Soderlund, 2012).…”

Section: • Voltage Channelsmentioning

confidence: 99%

Beyond Chemicals: Exploring Greener Options for Tick Control

Lakshmanan,

Nikhat Reena,

Anand

2023

JIVA

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Ticks are obligate haematophagous ectoparasites that feed on a variety of vertebrate host animals. They transmit a wide range of disease-causing organisms and are of great medical and veterinary importance. Several characteristics of ticks confer them outstanding attributes to serve as vectors of pathogenic agents, viz., the wide host range and tendency to feed on several hosts during life cycle ensures ample opportunity to acquire and transmit pathogens, hardiness and longevity enable them to survive long periods in unfavourable environmental conditions, high reproductive potential ensuring maintenance of large populations and a high frequency of host-vector contact. Conventional methods for tick control are based on the use of acaricides and insect growth regulators. The continuous emergence of ticks and tick-borne diseases (TTBs) and acaricide resistance of ticks necessitated the development of new and

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Section: • Voltage Channelsmentioning

confidence: 99%

Beyond Chemicals: Exploring Greener Options for Tick Control

Lakshmanan,

Nikhat Reena,

Anand

2023

JIVA

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Identification and Spatiotemporal Expression of a Putative New GABA Receptor Subunit in the Human Body Louse Pediculus humanus humanus

Hashim,

Toubaté,

Charvet

et al. 2024

Genes

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The human louse (Pediculus humanus) is an obligatory blood feeding ectoparasite with two ecotypes: the human body louse (Pediculus humanus humanus), a competent vector of several bacterial pathogens, and the human head louse (Pediculus humanus capitis), responsible for pediculosis and affecting millions of people around the globe. GABA (γ-aminobutyric acid) receptors, members of the cys-loop ligand gated ion channel superfamily, are among the main pharmacological targets for insecticides. In insects, there are four subunits of GABA receptors: resistant-to-dieldrin (RDL), glycin-like receptor of drosophila (GRD), ligand-gated chloride channel homologue3 (LCCH3), and 8916 are well described and form distinct phylogenetic clades revealing orthologous relationships. Our previous studies in the human body louse confirmed that subunits Phh-RDL, Phh-GRD, and Phh-LCCH3 are well clustered in their corresponding clades. In the present work, we cloned and characterized a putative new GABA receptor subunit in the human body louse that we named HoCas, for Homologous to Cys-loop α like subunit. Extending our analysis to arthropods, HoCas was found to be conserved and clustered in a new (fifth) phylogenetic clade. Interestingly, the gene encoding this subunit is ancestral and has been lost in some insect orders. Compared to the other studied GABA receptor subunits, HoCas exhibited a relatively higher expression level in all development stages and in different tissues of human body louse. These findings improved our understanding of the complex nature of GABA receptors in Pediculus humanus and more generally in arthropods.

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Correction: Transcriptome of the synganglion in the tick Ixodes ricinus and evolution of the cys-loop ligand-gated ion channel family in ticks

Cited by 2 publications

References 1 publication

Beyond Chemicals: Exploring Greener Options for Tick Control

Beyond Chemicals: Exploring Greener Options for Tick Control

Identification and Spatiotemporal Expression of a Putative New GABA Receptor Subunit in the Human Body Louse Pediculus humanus humanus

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