Correction: Transcription Factor TFAP2C Regulates Major Programs Required for Murine Fetal Germ Cell Maintenance and Haploinsufficiency Predisposes to Teratomas in Male Mice

Schemmer, Jana; AraÃozo-Bravo, Marcos J.; Haas, Natalie; SchÃ¤fer, Sabine; Weber, Susanne N.; Becker, Astrid; Eckert, Dawid; Zimmer, Andreas; Nettersheim, Daniel; Schorle, Hubert

doi:10.1371/annotation/579ac618-0ed0-4451-a4fc-10bad989024b

Cited by 4 publications

(2 citation statements)

References 50 publications

(67 reference statements)

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“…Interestingly, Tfap2c binds to the promoter of Nanos3 in mouse germ cells and Tfap2c-deficient germ cells demonstrate deregulation in epigenetic remodeling, cell cycle, and pluripotency genes. Mice with heterozygous deletion of both Tfap2c and Nanos3 develop germ cell cancer [ 43 ]. Similarly to NANOS3 overexpression in cancer, TFAP2C overexpression was also reported in various cancer types [ 44 ].…”

Section: Dysregulation Of Nanos Transcriptional Regulators In Cancermentioning

confidence: 99%

Emerging Roles of NANOS RNA-Binding Proteins in Cancer

Ilaslan

Sajek

Jaruzelska

et al. 2022

IJMS

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In recent years, growing evidence demonstrates that mammalian Nanos RNA-binding proteins (Nanos1, Nanos2, and Nanos3), known for their indispensable roles in germline development, are overexpressed in a variety of cancers. This overexpression contributes to various oncogenic properties including cancer growth, invasiveness, and metastasis. Here, we highlight recent findings regarding the role of mammalian Nanos RNA-binding proteins and the mechanisms of their overexpression in cancer. In addition, we present expression profiles of human NANOS genes and their oncogenic transcriptional regulators obtained from publicly available cancer and normal tissue RNA-Seq datasets. Altogether, we emphasize the functional significance of NANOS proteins across human cancers as well as highlight the missing links to understanding the full scope of their role in carcinogenesis.

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Section: Dysregulation Of Nanos Transcriptional Regulators In Cancermentioning

confidence: 99%

Emerging Roles of NANOS RNA-Binding Proteins in Cancer

Ilaslan

Sajek

Jaruzelska

et al. 2022

IJMS

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“…TFAP2C gene encodes a sequence-specific DNA-binding transcription factor, which is involved in activation of several developmental genes. It has a significant role in the development of primordial germ cells, and its altered expression was found in some cancer types, including murine germ cell tumors [64,65,66,67]. TRERF1 gene encodes a basal cell cycle regulatory protein that has been shown to play a key role in development of estrogen independence/resistance in solid tumors—e.g., breast cancer [68].…”

Section: Discussionmentioning

confidence: 99%

Molecular Basis of Cisplatin Resistance in Testicular Germ Cell Tumors

Bakardjieva-Mihaylova

Kramarzova

Slámová

et al. 2019

Cancers

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The emergence of cisplatin (CDDP) resistance is the main cause of treatment failure and death in patients with testicular germ cell tumors (TGCT), but its biologic background is poorly understood. To study the molecular basis of CDDP resistance in TGCT we prepared and sequenced CDDP-exposed TGCT cell lines as well as 31 primary patients’ samples. Long-term exposure to CDDP increased the CDDP resistance 10 times in the NCCIT cell line, while no major resistance was achieved in Tera-2. Development of CDDP resistance was accompanied by changes in the cell cycle (increase in G1 and decrease in S-fraction), increased number of acquired mutations, of which 3 were present within ATRX gene, as well as changes in gene expression pattern. Copy number variation analysis showed, apart from obligatory gain of 12p, several other large-scale gains (chr 1, 17, 20, 21) and losses (chr X), with additional more CNVs found in CDDP-resistant cells (e.g., further losses on chr 1, 4, 18, and gain on chr 8). In the patients’ samples, those who developed CDDP resistance and died of TGCT (2/31) showed high numbers of acquired aberrations, both SNPs and CNVs, and harbored mutations in genes potentially relevant to TGCT development (e.g., TRERF1, TFAP2C in one patient, MAP2K1 and NSD1 in another one). Among all primary tumor samples, the most commonly mutated gene was NSD1, affected in 9/31 patients. This gene encoding histone methyl transferase was also downregulated and identified among the 50 most differentially expressed genes in CDDP-resistant NCCIT cell line. Interestingly, 2/31 TGCT patients harbored mutations in the ATRX gene encoding a chromatin modifier that has been shown to have a critical function in sexual differentiation. Our research newly highlights its probable involvement also in testicular tumors. Both findings support the emerging role of altered epigenetic gene regulation in TGCT and CDDP resistance development.

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The PRAME family of cancer testis antigens is essential for germline development and gametogenesis

Kern

Yang

Liu

2021

Biology of Reproduction

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The precise mechanisms of the reproductive physiological processes, such as labor initiation, are poorly understood. Oxytocin (OT) is one of the well-known uterotonics and is clinically adopted as a medication to facilitate childbirth. Vasopressin (VP), a posterior pituitary hormone similar to OT, has also been proposed to be involved in the reproductive physiology. In this study, we found that a total deficiency of V1a receptor subtype (V1aR) in mice resulted in a reduced number of pups, delayed labor initiation, and increased post-delivery hemorrhage compared with those in wild-type mice. Among the VP receptor subtypes, only V1aR was found to be expressed in the murine uterus and its distribution pattern was different from that of the oxytocin receptor (OTR); V1aR expression was mainly distributed in the circular myometrium, whereas OTR was strongly expressed in both the circular and longitudinal myometrium. The maximum contractile force of the circular myometrium, induced by VP or OT, was attenuated in the pregnant uterus of Avpr1a-deficient mice. Contrarily, while OT expression was decreased in the Avpr1a-deficient uterus, OTR expression was significantly increased. These results suggest that V1aR deficiency not only reduces the uterine contractile force but also perturbs the expression of genes responsible for the reproductive physiology. Therefore, V1aR is necessary to exert the maximum contraction of the circular myometrium to deliver pups. This study revealed an important role of V1aR in physiological contraction and term parturition in mice.

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Correction: Transcription Factor TFAP2C Regulates Major Programs Required for Murine Fetal Germ Cell Maintenance and Haploinsufficiency Predisposes to Teratomas in Male Mice

Cited by 4 publications

References 50 publications

Emerging Roles of NANOS RNA-Binding Proteins in Cancer

Emerging Roles of NANOS RNA-Binding Proteins in Cancer

Molecular Basis of Cisplatin Resistance in Testicular Germ Cell Tumors

The PRAME family of cancer testis antigens is essential for germline development and gametogenesis

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