Correction to: The potential prognostic utility of salivary galectin-3 concentrations in heart failure

Xi, Zhang; Karunathilaka, Nuwan; Senanayake, Sameera; Subramaniam, V. Nathan; Chan, W.; Kostner, Karam; Atherton, J.; Punyadeera, Chamindie

doi:10.1007/s00392-019-01583-y

Cited by 1 publication

(4 citation statements)

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Section: Laboratory Assays Using Saliva As a Matrixmentioning

confidence: 99%

“…There is now ample evidence linking oral health to systemic diseases [27]. Salivary biomarkers have been used to diagnose head and neck cancer, breast cancer, heart failure, periodontal disease, salivary gland diseases, drugs of abuse and COVID-19 [28][29][30][31][32][33][34][35][36][37][38][39][40]. These applications are still in a research phase.…”

Section: Saliva As a Diagnostic Fluid For The Detection Of Oral And S...mentioning

confidence: 99%

“…Saliva offers potential as an alternative diagnostic medium to blood based tests, due to the oral cavity's dense vascularization, circulating molecules are transported into saliva that can be utilized to detect underlying disease. Laboratorybased tests can quantify biomarkers of clinical relevance in saliva samples for a large number of oral and systemic diseases [35,36,47,[67][68][69]. Biomarker detection is gaining attention in the medical field for monitoring physical conditions of the body.…”

Section: Laboratory Assays Using Saliva As a Matrixmentioning

confidence: 99%

“…Given the demonstrated diagnostic utility of saliva, its application has been further specialised into novel diagnostic methods for head and neck cancers of varying etiology [29,30]. Studies have further demonstrated that the salivary proteome can be quantified to diagnose and stratify HF patients [23,36]. The current COVID-19 pandemic has lifted the salivary diagnostic field to new heights, with a clinical need for rapid POC diagnostic devices to efficiently diagnose patients with the rampant virus.…”

Section: Laboratory Assays Using Saliva As a Matrixmentioning

confidence: 99%

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Saliva-based microfluidic point-of-care diagnostic

Pittman¹,

Decsi²,

Punyadeera³

et al. 2023

Theranostics

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There has been a long-standing interest in point-of-care (POC) diagnostics as a tool to improve patient care because it can provide rapid, actionable results near the patient. Some of the successful examples of POC testing include lateral flow assays, urine dipsticks, and glucometers. Unfortunately, POC analysis is somewhat limited by the ability to manufacture simple devices to selectively measure disease specific biomarkers and the need for invasive biological sampling. Next generation POCs are being developed that make use of microfluidic devices to detect biomarkers in biological fluids in a non-invasive manner, addressing the above-mentioned limitations. Microfluidic devices are desirable because they can provide the ability to perform additional sample processing steps not available in existing commercial diagnostics. As a result, they can provide more sensitive and selective analysis. While most POC methods make use of blood or urine as a sample matrix, there has been a growing push to use saliva as a diagnostic medium. Saliva represents an ideal non-invasive biofluid for detecting biomarkers because it is readily available in large quantities and analyte levels reflect those in blood. However, using saliva in microfluidic devices for POC diagnostics is a relatively new and an emerging field. The overarching aim of this review is to provide an update on recent literature focused on the use of saliva as a biological sample matrix in microfluidic devices. We will first cover the characteristics of saliva as a sample medium and then review microfluidic devices that are developed for the analysis of salivary biomarkers.

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