Correction to: Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex

Olivier, C; Hemming, Isabel; Gladwyn-Ng, Ivan; Qu, Zhengdong; Li, Shan Shan; Piper, Michael; Heng, Julian Ik‐Tsen

doi:10.1186/s13064-017-0098-x

Cited by 15 publications

(20 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At 4 dpf, zebrafish have an established anatomical organization of neurons in the brain and spinal cord but myelination is ongoing, similar to newborn children (Fig 1A). Cells that compose the spinal sensory root are organized by 2–3 dpf, before our avulsion model at 4 dpf [21,22]. These injuries were created by exposing a 4 μm region of the spinal cord sensory root nerve to pulses of a laser in Tg(ngn1 : gfp) zebrafish, which use regulatory sequences of ngn1 to express green fluorescent protein (GFP) in dorsal root ganglia (DRG) neurons [21,23] (S1 Movie).…”

Section: Resultsmentioning

confidence: 99%

“…Cells that compose the spinal sensory root are organized by 2–3 dpf, before our avulsion model at 4 dpf [21,22]. These injuries were created by exposing a 4 μm region of the spinal cord sensory root nerve to pulses of a laser in Tg(ngn1 : gfp) zebrafish, which use regulatory sequences of ngn1 to express green fluorescent protein (GFP) in dorsal root ganglia (DRG) neurons [21,23] (S1 Movie). To confirm that the laser induced root avulsion, we first created intensity surface plots along DRG projections and measured an absence of intensity in the afferent projection specifically where the laser was exposed (Fig 1B, S1A and S1B Fig).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Microglia exit the CNS in spinal root avulsion

2019

View full text Add to dashboard Cite

Microglia are central nervous system (CNS)-resident cells. Their ability to migrate outside of the CNS, however, is not understood. Using time-lapse imaging in an obstetrical brachial plexus injury (OBPI) model, we show that microglia squeeze through the spinal boundary and emigrate to peripheral spinal roots. Although both macrophages and microglia respond, microglia are the debris-clearing cell. Once outside the CNS, microglia re-enter the spinal cord in an altered state. These peripheral nervous system (PNS)-experienced microglia can travel to distal CNS areas from the injury site, including the brain, with debris. This emigration is balanced by two mechanisms—induced emigration via N -methyl-D-aspartate receptor (NMDA) dependence and restriction via contact-dependent cellular repulsion with macrophages. These discoveries open the possibility that microglia can migrate outside of their textbook-defined regions in disease states.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Microglia exit the CNS in spinal root avulsion

2019

View full text Add to dashboard Cite

show abstract

“…The central outcome of this study concerns the control pathways involved in the role of both adhesive glycoproteins and polyphenols in developing nervous tissue patterning, the Notch pathway representing a relevant link between them (Louvi and Artavanis-Tsakonas, 2006; Pierfelice et al, 2011; Wang, 2011; Dhanesh et al, 2016). Indeed, neural development implies the coordination among a wide set of processes during both early and late neurogenesis (Ishibashi, 2004; Barros et al, 2011; Paridaen and Huttner, 2014; Hardwick et al, 2015; Clément et al, 2018), which depends upon precursor interactions with either the surfaces of flanking cells and/or extracellular matrix components (Schmidt and Rathjen, 2010; Hirano and Takeichi, 2012; Frei and Stoeckli, 2014; Petrovic and Schmucker, 2015). Such interactions are critical for tissue morphogenesis as they modulate precursor differentiation (Pfeuty, 2015; Kalcheim, 2018) through activation of signaling pathways (Kanemoto et al, 2014), among which a key role is played by the one associated with Notch receptors (Ruijtenberg and van den Heuvel, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…These effects imply transcriptional activation of the S phase kinase-associated protein SKP2, a subunit of the ubiquitin-ligase SCF SKP2 complex whose upregulation enhances proteasome-mediated degradation of the Cyclin Kinase inhibitors (CKIs) p21 Cip1 and p27 Kip1 (Bornstein et al, 2003; Sarmento et al, 2005), which in turn promotes precursor cell cycle entry and therefore proliferation. At the same time, precursor migration is also promoted, which contributes to the overall positive effects on neurogenesis (Clément et al, 2018) by modulating the balance of proliferation versus differentiation events (Ishibashi, 2004; Nelson et al, 2007). Given that the Notch pathway is activated by interactions with Contactin1 (Hu et al, 2003, 2006; Bizzoca et al, 2012), it may then be inferred that a key developmental function of Contactin proteins and of the associated Notch pathway is to mediate the control of tissue patterning, including precursor cell cycle exit, migration and differentiation (Imayoshi et al, 2013; Dhanesh et al, 2016; Zhang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Modulation of Nerve Cell Differentiation: Role of Polyphenols and of Contactin Family Components

Picocci

Bizzoca

Corsi

et al. 2019

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

In this study the mechanisms are explored, which modulate expression and function of cell surface adhesive glycoproteins of the Immunoglobulin Supergene Family (IgSF), and in particular of its Contactin subset, during neuronal precursor developmental events. In this context, a specific topic concerns the significance of the expression profile of such molecules and their ability to modulate signaling pathways activated through nutraceuticals, in particular polyphenols, administration. Both in vitro and in vivo approaches are chosen. As for the former, by using as a model the human SH-SY5Y neuroblastoma line, the effects of grape seed polyphenols are evaluated on proliferation and commitment/differentiation events along the neuronal lineage. In SH-SY5Y cell cultures, polyphenols were found to counteract precursor proliferation while promoting their differentiation, as deduced by studying their developmental parameters through the expression of cell cycle and neuronal commitment/differentiation markers as well as by measuring neurite growth. In such cultures, Cyclin E expression and BrdU incorporation were downregulated, indicating reduced precursor proliferation while increased neuronal differentiation was inferred from upregulation of cell cycle exit (p27 –Kip ) and neuronal commitment (NeuN) markers as well as by measuring neurite length through morphometric analysis. The polyphenol effects on developmental parameters were also explored in vivo , in cerebellar cortex, by using as a model the TAG/F3 transgenic line, which undergoes delayed neural development as a consequence of Contactin1 adhesive glycoprotein upregulation and premature expression under control of the Contactin2 gene ( Cntn-2 ) promoter. In this transgenic line, a Notch pathway activation is known to occur and polyphenol treatment was found to counteract such an effect, demonstrated through downregulation of the Hes-1 transcription factor. Polyphenols also downregulated the expression of adhesive glycoproteins of the Contactin family themselves, demonstrated for both Contactin1 and Contactin2, indicating the involvement of changes in the expression of the underlying genes in the observed phenotype. These data support the hypothesis that the complex control exerted by polyphenols on neural development involves modulation of expression and function of the genes encoding cell adhesion molecules of the Contactin family and of the associated signaling pathways, indicating potential mechanisms whereby such compounds may control neurogenesis.

show abstract

“…However, the exact time of establishment of fully functional synaptic structures is somehow vague. Synapses are complex and comprise many molecules which are supposed to be specific, but have a remarkably variable expression span and, often, functionality ( Farhy-Tselnicker and Allen, 2018 ; Südhof, 2018 ).…”

Section: Synaptogenesis and “Synaptic” Proteinsmentioning

confidence: 99%

How Do Electric Fields Coordinate Neuronal Migration and Maturation in the Developing Cortex?

Medvedeva

Pierani

2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

During development the vast majority of cells that will later compose the mature cerebral cortex undergo extensive migration to reach their final position. In addition to intrinsically distinct migratory behaviors, cells encounter and respond to vastly different microenvironments. These range from axonal tracts to cell-dense matrices, electrically active regions and extracellular matrix components, which may all change overtime. Furthermore, migrating neurons themselves not only adapt to their microenvironment but also modify the local niche through cell-cell contacts, secreted factors and ions. In the radial dimension, the developing cortex is roughly divided into dense progenitor and cortical plate territories, and a less crowded intermediate zone. The cortical plate is bordered by the subplate and the marginal zone, which are populated by neurons with high electrical activity and characterized by sophisticated neuritic ramifications. Neuronal migration is influenced by these boundaries resulting in dramatic changes in migratory behaviors as well as morphology and electrical activity. Modifications in the levels of any of these parameters can lead to alterations and even arrest of migration. Recent work indicates that morphology and electrical activity of migrating neuron are interconnected and the aim of this review is to explore the extent of this connection. We will discuss on one hand how the response of migrating neurons is altered upon modification of their intrinsic electrical properties and whether, on the other hand, the electrical properties of the cellular environment can modify the morphology and electrical activity of migrating cortical neurons.

show abstract

Correction to: Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex

Cited by 15 publications

References 2 publications

Microglia exit the CNS in spinal root avulsion

Microglia exit the CNS in spinal root avulsion

Modulation of Nerve Cell Differentiation: Role of Polyphenols and of Contactin Family Components

How Do Electric Fields Coordinate Neuronal Migration and Maturation in the Developing Cortex?

Contact Info

Product

Resources

About