Correction to: RNA-seq reveals tight junction-relevant erythropoietic fate induced by OCT4 in human hair follicle mesenchymal stem cells

Yu, Xiaozhen; Sun, Pengpeng; Huang, Xingang; Chen, Hua; Huang, Weiqing; Ruan, Yingchun; Jiang, Weina; Tan, Xiaohua; Liu, Zhijing

doi:10.1186/s13287-020-02079-7

Cited by 2 publications

(1 citation statement)

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“…Intercellular junctions, such as adherens and tight junctions, are responsible for connecting each cell to each other to establish a tight skin barrier 43 . A recent study showed that overexpression of Oct4 influenced the morphology and adhesion of human hair follicle mesenchymal stem cells 65 . We found that loss of Oct4 in skin keratinocytes diminished E-cadherin and β-catenin from cell-cell contacts by altering their localization, and inhibited their colocalization at the plasma membrane, possibly by impairing the interaction between the two proteins.…”

Section: Discussionmentioning

confidence: 99%

Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes

Christofidou

Tomazou

Voutouri

et al. 2023

Preprint

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Oct4 is a pioneer transcription factor regulating pluripotency. However, it is poorly known whether Oct4 has an impact on somatic cells. We generated OCT4 knockout clonal cell lines using immortalized human skin keratinocytes to identify a functional role for the protein. Here we report that Oct4-deficient cells transitioned into a mesenchymal-like phenotype with enlarged size and shape, exhibited accelerated migratory behavior, decreased adhesion and appeared arrested at G2/M cell cycle checkpoint. Oct4 absence had a profound impact on cortical actin organization, with loss of microfilaments from cell periphery, increased puncta deposition in the cytoplasm and stress fiber formation. E-cadherin, beta-catenin and ZO1 were almost absent from cell-cell contacts while fibronectin deposition was markedly increased in ECM. Mapping of the transcriptional and chromatin profiles of Oct4-deficient cells revealed that Oct4 controls the levels of cytoskeletal, ECM and differentiation related genes, whereas epithelial identity is preserved through transcriptional and non-transcriptional mechanisms.

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Section: Discussionmentioning

confidence: 99%

Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes

Christofidou

Tomazou

Voutouri

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes

Christofidou,

Tomazou,

Voutouri

et al. 2024

Cell Reports

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Correction to: RNA-seq reveals tight junction-relevant erythropoietic fate induced by OCT4 in human hair follicle mesenchymal stem cells

Abstract: An amendment to this paper has been published and can be accessed via the original article.

Cited by 2 publications

References 1 publication

Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes

Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes

Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes

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