Correction to Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor

Seo, Gon; Lee, Geonhee; Kim, Mi Jeong; Baek, Seung Hwa; Choi, Minsuk; Ku, Keun Bon; Lee, Chang Seop; Jun, Sangmi; Park, Daeui; Kim, Hong Gi; Kim, Seong Jun; Lee, Jeong O.; Kim, Bum Tae; Park, Edmond Changkyun; Kim, Kyung Sik

doi:10.1021/acsnano.0c06726

Cited by 68 publications

(70 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the case of applying Graphene, the detection of SARS-CoV-2 in clinical samples was attempted with a sensor produced by coating the graphene sheet of the field-effect transistor with a specific antibody against the SARS-CoV-2 spike protein. 275 As a result of the study, it was possible to detect SARS-CoV-2 spike protein at a concentration of 1 fg/mL in phosphate-buffered saline and 100 fg/mL clinical transport medium. 275 …”

Section: Application Of Nanotechnology In Covid-19 Therapeuticsmentioning

confidence: 95%

“… 275 As a result of the study, it was possible to detect SARS-CoV-2 spike protein at a concentration of 1 fg/mL in phosphate-buffered saline and 100 fg/mL clinical transport medium. 275 …”

Section: Application Of Nanotechnology In Covid-19 Therapeuticsmentioning

confidence: 95%

“…International Journal of Nanomedicine 2021:16 produced by coating the graphene sheet of the field-effect transistor with a specific antibody against the SARS-CoV-2 spike protein. 275 As a result of the study, it was possible to detect SARS-CoV-2 spike protein at a concentration of 1 fg/ mL in phosphate-buffered saline and 100 fg/mL clinical transport medium. 275 The SARS-CoV-2 biosensor using thiol-modified antisense oligonucleotides-capped GNs can diagnose positive COVID-19 cases with the naked eye through color change within 10 minutes from total RNA isolated from infected biosamples.…”

Section: Dovepressmentioning

confidence: 95%

“…275 As a result of the study, it was possible to detect SARS-CoV-2 spike protein at a concentration of 1 fg/ mL in phosphate-buffered saline and 100 fg/mL clinical transport medium. 275 The SARS-CoV-2 biosensor using thiol-modified antisense oligonucleotides-capped GNs can diagnose positive COVID-19 cases with the naked eye through color change within 10 minutes from total RNA isolated from infected biosamples. 276 As another application method for GNs, the glycan bond between the polymer-stabilized multivalent GNs bearing sialic acid derivative and the S protein of SARS-CoV-2 was identified using a glyconanoparticle platform.…”

Section: Dovepressmentioning

confidence: 95%

See 3 more Smart Citations

Application of Nanotechnology in the COVID-19 Pandemic

Yang¹

2021

IJN

View full text Add to dashboard Cite

COVID-19, caused by SARS-CoV-2 infection, has been prevalent worldwide for almost a year. In early 2000, there was an outbreak of SARS-CoV, and in early 2010, a similar dissemination of infection by MERS-CoV occurred. However, no clear explanation for the spread of SARS-CoV-2 and a massive increase in the number of infections has yet been proposed. The best solution to overcome this pandemic is the development of suitable and effective vaccines and therapeutics. Fortunately, for SARS-CoV-2, the genome sequence and protein structure have been published in a short period, making research and development for prevention and treatment relatively easy. In addition, intranasal drug delivery has proven to be an effective method of administration for treating viral lung diseases. In recent years, nanotechnology-based drug delivery systems have been applied to intranasal drug delivery to overcome various limitations that occur during mucosal administration, and advances have been made to the stage where effective drug delivery is possible. This review describes the accumulated knowledge of the previous SARS-CoV and MERS-CoV infections and aims to help understand the newly emerged SARS-CoV-2 infection. Furthermore, it elucidates the achievements in developing COVID-19 vaccines and therapeutics to date through existing approaches. Finally, the applicable nanotechnology approach is described in detail, and vaccines and therapeutic drugs developed based on nanomedicine, which are currently undergoing clinical trials, have presented the potential to become innovative alternatives for overcoming COVID-19.

show abstract

Section: Application Of Nanotechnology In Covid-19 Therapeuticsmentioning

confidence: 95%

“… 275 As a result of the study, it was possible to detect SARS-CoV-2 spike protein at a concentration of 1 fg/mL in phosphate-buffered saline and 100 fg/mL clinical transport medium. 275 …”

Section: Application Of Nanotechnology In Covid-19 Therapeuticsmentioning

confidence: 95%

Section: Dovepressmentioning

confidence: 95%

Section: Dovepressmentioning

confidence: 95%

See 2 more Smart Citations

Application of Nanotechnology in the COVID-19 Pandemic

Yang¹

2021

IJN

View full text Add to dashboard Cite

show abstract

“…Many methods based on traditional molecular diagnostics have been developed for COVID-19 detection and more novel methods utilizing nanoparticles as the indicators are under development [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. Those methods mainly fall into two categories, a serological test and nucleic acid test.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 RNA Detection with Duplex-Specific Nuclease Signal Amplification

Liu

Jia

et al. 2021

Micromachines

View full text Add to dashboard Cite

The emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a zoonotic pathogen, has led to the outbreak of coronavirus disease 2019 (COVID-19) pandemic and brought serious threats to public health worldwide. The gold standard method for SARS-CoV-2 detection requires both reverse transcription (RT) of the virus RNA to cDNA and then polymerase chain reaction (PCR) for the cDNA amplification, which involves multiple enzymes, multiple reactions and a complicated assay optimization process. Here, we developed a duplex-specific nuclease (DSN)-based signal amplification method for SARS-CoV-2 detection directly from the virus RNA utilizing two specific DNA probes. These specific DNA probes can hybridize to the target RNA at different locations in the nucleocapsid protein gene (N gene) of SARS-CoV-2 to form a DNA/RNA heteroduplex. DSN cleaves the DNA probe to release fluorescence, while leaving the RNA strand intact to be bound to another available probe molecule for further cleavage and fluorescent signal amplification. The optimized DSN amount, incubation temperature and incubation time were investigated in this work. Proof-of-principle SARS-CoV-2 detection was demonstrated with a detection sensitivity of 500 pM virus RNA. This simple, rapid, and direct RNA detection method is expected to provide a complementary method for the detection of viruses mutated at the PCR primer-binding regions for a more precise detection.

show abstract

Graphene Transistors for In Vitro Detection of Health Biomarkers

Dai

Kong

Chen

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Biomarkers are primary indicators for precise diagnosis and treatment. The early identification of health biomarkers has been sustained by the evolutionary success in sensor technologies. Among them, graphene field-effect transistor (GFET) biosensors have exhibited major advantages such as an ultrashort response time, high sensitivity, easy operation, capability of integration, and label-free detection. Owing to the atomic thickness, graphene restricts charge carrier flow merely at the material surface and responds to foreign stimuli directly, leading to effective signal acquisition and transmission. Here, this review summarizes the latest advances in GFET biosensors in a comprehensive manner that contains the device design, working principle, surface functionalization, and proof-of-concept applications. It provides a comprehensive survey of GFET biosensors with regard to biomarker analysis at the single-device level and integrated prototypes that include wearable sensors, biomimetic systems, healthcare electronics, and diagnostic platforms. Moreover, there is discussion on the long-standing research efforts and outlook for the future development of GFET sensor systems from lab to fab.

show abstract

Correction to Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor

Cited by 68 publications

References 0 publications

Application of Nanotechnology in the COVID-19 Pandemic

Application of Nanotechnology in the COVID-19 Pandemic

SARS-CoV-2 RNA Detection with Duplex-Specific Nuclease Signal Amplification

Graphene Transistors for In Vitro Detection of Health Biomarkers

Contact Info

Product

Resources

About