Correction to Quercetin-Modified Metal–Organic Frameworks for Dual Sensitization of Radiotherapy in Tumor Tissues by Inhibiting the Carbonic Anhydrase IX

A Comprehensive Evaluation of ZrC Nanoparticle in Combined Photothermal and Radiation Therapy for Treatment of Triple-Negative Breast Cancer

“…The same expression trend of Hif-1a showed up in immunohistochemical analysis. As the tumor growth inhibition rates were positive correlated to absorption doses and the improvement of hypoxic environment can promote the absorption of radiotherapy (22,29). To summarize the above experimental data in vivo, a conclusion can be drawn that the combination of PT and RT with ZrC NPs alleviate hypoxia induced resistance of RT and sensitizing tumor tissues to absorb more doses of PT and RT, improving cell apoptosis and tumor suppression rate.…”

“…The photothermal nanomaterial at tumor site creates local hyperthermia under external near infrared (NIR) irradiation (20,21). The in vivo hyperthermia not only contributes to necrosis or apoptosis of cancer cells, but also creates an oxygen-enriched environment, and in effect reduces radiotherapy resistance (22). In combination with PT, lower dose in RT could be sufficient to kill the tumor and simultaneously enhance systemic antitumor immune response, while high dose RT cause damage to immune system (23,24).…”

Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging

“…For instance, researchers prepared quercetin-loaded Zr-metal-organic framework nanoparticles to improve the irradiation energy absorption and downregulate hypoxic tumor conditions ( Fig. 5 ) [ 136 ]. The nanoparticle was fabricated using Zr-metal-organic framework as a carbonic anhydrase IX inhibitor and quercetin as a radiosensitizer for dual sensitization of radiotherapy in hypoxic tumors.…”

“…*p < 0.05, **p < 0.01, ***p < 0.001. Adapted with permission [ 136 ]. Copyright 2019, American Chemical Society.…”