Correction to: Proton therapy for adult medulloblastoma: Acute toxicity and disease control outcomes

Liu, I-Chia; Holtzman, Adam L.; Rotondo, Ronny L.; Indelicato, Daniel J.; Gururangan, Sridharan; Cavaliere, Robert; Carter, Bridgette; Morris, Christopher G.; Tavanaiepour, Daryoush; Rutenberg, M.S.

doi:10.1007/s11060-021-03798-4

Cited by 1 publication

(8 citation statements)

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“…It is noteworthy that at 2 years, the reported actuarial freedom from G ≥ 3 toxicity was greater than 90% (Figure 2). These data compares favorably with previous studies [3][4][5][6][7][8]16 and supports the safety and efficacy of proton CSI for the control of CNS tumors.…”

Section: Discussionsupporting

confidence: 83%

“…Liu et al reported 4-year LC and DFS of a cohort of 15 AYAs with medulloblastoma of 90% and 90%, respectively. 8 Importantly, LC, DC, and OS were 100% among AYAs in our cohort. Due to the small numbers, the difference of these outcome-metrics was not statistically different when compared to children (Table 2).…”

Section: Discussionmentioning

confidence: 61%

“…Our 2year LC, DC, and OS rates of 86.3%, 80.5% and 84.7%, respectively, are consistent with recent reports investigating the use of CSI with protons among children and AYAs. [3][4][5][6][7][8] Of note, patients with recurrent or metastatic tumors at the start of PT were found to have a worse outcome. Our acute toxicity data, points to an adequate tolerance of the treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Similar results were found in reported PT CSI for medulloblastoma patients, with a median time to recurrence of around 15-30 months. 3,4,6,8 Most data in the literature regarding patterns of failure after proton CSI are reported in patients with medulloblastoma.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6] Likewise, retrospective studies of adolescents and young adults (AYAs) treated with proton CSI have also reported promising results in terms of toxicity and tumor control rates. 7,8 The role of PBSPT for other histologies that may require CSI has been less investigated. 9 The aim of our study was to report clinical outcomes, toxicity, and potential prognostic factors of a cohort of C-AYAs referred to our institution to receive CSI delivered with protons.…”

mentioning

confidence: 99%

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Early outcome after craniospinal irradiation with pencil beam scanning proton therapy for children, adolescents and young adults with brain tumors

Vazquez

Bachmann

Pica

et al. 2022

Pediatric Blood & Cancer

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Central nervous system (CNS) tumors are the most common solid malignancies in children and adolescents and young adults (C-AYAs). Craniospinal irradiation (CSI) is an essential treatment component for some malignancies, but it can also lead to important toxicity. Pencil beam scanning proton therapy (PBSPT) allows for a minimization of dose delivered to organs at risk and, thus, potentially reduced acute and late toxicity. This study aims to report the clinical outcomes and toxicity rates after CSI for C-AYAs treated with PBSPT. Seventy-one C-AYAs (median age: 7.4 years) with CNS tumors were treated with CSI between 2004 and 2021. Medulloblastoma (n = 42: 59%) and ependymoma (n = 8; 11%) were the most common histologies. Median prescribed total PBSPT dose was 54 Gy RBE (range: 18-60.4), and median prescribed craniospinal dose was 24 Gy RBE (range: 18-36.8). Acute and late toxicities were coded according to Common Terminology Criteria for Adverse Events. After a median follow-up of 24.5 months, the estimated 2-year local control, distant control, and overall survival were 86.3%, 80.5%, and 84.7%, respectively. Late grade ≥3 toxicity-free rate was 92.6% at 2 years. Recurrent and metastatic tumors were associated with worse outcome. In conclusion, excellent tumor control with low toxicity rates was observed in C-AYAs with brain tumors treated with CSI using PBSPT. K E Y W O R D Sadolescents and young adults, brain tumors, children, patient-related outcomes, pencil beam scanning, proton therapy, toxicity INTRODUCTIONCraniospinal irradiation (CSI) is an essential treatment component along with surgery and chemotherapy for many children, adolescents

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