Correction to: Potential role of lncRNA-TSIX, miR-548-a-3p, and SOGA1 mRNA in the diagnosis of hepatocellular carcinoma

Habieb, Alaa; Matboli, Marwa; El-Tayeb, Hanaa; El-Asmar, Farid

doi:10.1007/s11033-019-04838-z

Cited by 2 publications

(2 citation statements)

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“…circRGNEF downregulation promoted miR-548 expression and miR-548 silencing restored migration, proliferation, and invasion following circRGNEF knockdown. miR-548 overexpression suppressed BC cell migration, proliferation, and invasion, which is consistent with previous studies [25,26].…”

Section: Agingsupporting

confidence: 92%

Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation

Yang

Chen

et al. 2020

Aging

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Circular RNAs (circRNAs) play an important role in bladder cancer (BC). Though circRNA involvement in BC has been reported, the underlying regulatory mechanisms are unknown. In this study, we performed EdU, CCK8, colony formation and Transwell assays to establish the role of circRGNEF in BC cell migration, proliferation, and invasion. We used bioinformatics and luciferase reporter experiments to investigate the regulatory mechanism. Nude mice xenografts and live imaging were used to explore the role of circRGNEF in tumor metastasis and growth. Expression profile analysis of human circRNAs in BC revealed that circRGNEF was upregulated significantly. High circRGNEF expression was correlated with aggressive BC phenotypes. The downregulation of circRGNEF suppressed BC cell metastasis and proliferation by targeting the miR-548/KIF2C axis in vitro and in vivo; these results were verified with luciferase reporter assays. Our results show that miR-548 downregulation or KIF2C overexpression restored BC cell proliferation, migration, and invasion following silencing of circRGNEF. KIF2C overexpression reversed miR-548-induced cell invasion and migration as well as growth inhibition in vitro. In summary, the data illustrate that circRGNEF suppresses BC progression by functioning as a miR-548 sponge to enhance KIF2C expression. Therefore, circRGNEF might be a candidate BC treatment target.

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Section: Agingsupporting

confidence: 92%

Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation

Yang

Chen

et al. 2020

Aging

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“…Researches have found that lncRNAs are involved in multiple steps of cancer development, and they can be used as sensitive biomarkers to predict cancer metastasis [10, 11]. Moreover, lncRNAs have been identified in body fluids [12–14] and are emerging as novel biomarkers for disease and as targets for disease intervention [15, 16]. Based on the expression profile of serum lncRNAs in HCC LNM [17], we quantitatively analyzed the candidate lncRNAs in the serum samples of 242 patients and evaluated the correlation between the lncRNAs and HCC LNM.…”

Section: Introductionmentioning

confidence: 99%

A Noninvasive Prediction Nomogram for Lymph Node Metastasis of Hepatocellular Carcinoma Based on Serum Long Noncoding RNAs

Zhang

Bian

et al. 2019

BioMed Research International

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Background and Objectives. Lymph node metastasis (LNM) is common in hepatocellular carcinoma (HCC). In order to intervene HCC LNM in advance, we developed a prediction nomogram based on serum long noncoding RNA (lncRNA). Methods. Serum samples from 242 HCC patients were gathered and randomly enrolled into the training and validation cohorts. LncRNAs screened out from microarray were quantified with qRT-PCR. Univariate and multivariate analyses were applied for screening independent risk factors. A prediction nomogram was ultimately developed for HCC LNM. The nomogram was estimated by discrimination and calibration tests in the validation cohort. The effects of the candidate lncRNA on the malignant phenotypes of HCC cells were further explored by wound healing assay and colony formation assay. Results. ENST00000418803, lnc-ZNF35-4:1, lnc-EPS15L1-2:1, BCLC stage, and vascular invasion were selected as components of the nomogram according to the adjusted multivariate analysis. The nomogram effectively predicted the HCC LNM risk among the cohorts with suitable calibration fittings and displayed high discrimination with C-index of 0.89 and 0.85. Moreover, the abnormally high expression of lnc-EPS15L1-2:1 in HCC cell lines showed significant carcinogenic effects. Conclusions. The noninvasive nomogram may provide more diagnostic basis for treatments of HCC. The biomarkers identified can bring new clues to basic researches.

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Correction to: Potential role of lncRNA-TSIX, miR-548-a-3p, and SOGA1 mRNA in the diagnosis of hepatocellular carcinoma

Cited by 2 publications

References 0 publications

Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation

Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation

A Noninvasive Prediction Nomogram for Lymph Node Metastasis of Hepatocellular Carcinoma Based on Serum Long Noncoding RNAs

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