Correction to: Positive postprandial glycaemic and appetite-related effects of wheat breads enriched with either α-cyclodextrin or hydroxytyrosol/α-cyclodextrin inclusion complex

The effect of alpha-cyclodextrin on postprandial glucose excursions, a systematic meta analysis Alpha-cyclodextrin and Blood Glucose

“…The comparisons based on the four subsequent studies [4,5,[21][22][23], excluding the two studies serving high-fat meals [11,17], are consistent with a dose-response relationship [14]:…”

“…In particular, having one of several studies not reaching the conventional level of significance (P < 0.05) does not, in itself, create an inconsistency. With the FCPT (Fisher 1948) , adding a study with P < 0.37 (Sugahara 2016;Binou 2022a;b) typically suffices to strengthen the overall significance. (Elston 1991) • Cross-over studies often have more power than two-group comparisons because data coming from the same person tend to be correlated.…”

“…Still, the presence of at least one significant difference between "groups" suggests that the results increase the significance from the other two studies. Significant efficacy from at least two studies (Buckley 2006;Binou 2022a;b) . 10 g/ 50 g: The 10 g dose was significant in the initial (Buckley 2006) and in a second study (Bär 2020) (P < 0.001 and P < 0.05, respectively, combined P < 0.00055) (Fisher 1948) .…”

“…5 g / 50 g: In the initial [14] and a second study [22,23], 5 g were significant (at P = 0.03 and P = 0.06, respectively, combined P = 0.013 [8], well below the FCPT cut-off of 0.0175). One of the "10 g" studies (actually: 5 g per 50 g sucrose) is excluded from this meta-analysis because the participants were older (68-76 yr) and consumed a sucrose drink [4], rather than a highcarb meal.…”

“…(7) Binou et al (2022) [22,23] NCT04725955 : 10 healthy adults age 18-41 (28.2±6.8) consumed white wheat bread (50 g carbohydrates, 2-4 g fat, 10-12 g protein) with 0 or 5 g of αCD. Postprandial glucose and insulin were measured.…”