Correction to: Phase 2 Open-Label Trial Investigating Percutaneous Laser Ablation for Treatment of Early-Stage Breast Cancer: MRI, Pathology, and Outcome Correlations

Schwartzberg, Barbara S.; Lewin, John M.; Abdelatif, Osama; Bernard, Jacqueline; Bu-Ali, Hanadi; Cawthorn, Simon; Chen-Seetoo, Margaret; Feldman, Sheldon; Govindarajulu, Srinivas; Jones, Lyn; Juette, Arne; Kavia, Sanjay; Maganini, Robert; Pain, Simon; Shere, Mike; Shriver, Craig D.; Smith, Simon; Whitacre, Eric; Whitney, Roger

doi:10.1245/s10434-018-6861-3

Cited by 1 publication

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This value is far higher than the ablation rates found in literature about the exclusive use of LITT. 12 - 15 Just in one case we observed a tumor residue (respectively, 2 foci of 1.5 and 2 mm). We would highlight that it was the first Patient of our trial, the reason why failed ablation could be related to the lesser confidence with the technique.…”

Section: Discussionmentioning

confidence: 76%

“…Indirect effects occur after thermo-ablation by progressive destruction of the tissue by vaporization, microvascular damage, necrosis and the activation of a strong immune reaction capable of attacking the residual tumor. 14 , 15 Compared to other methods, the main advantage of using laser light for thermal applications is its ability to focus a precise amount of energy in a restricted area, inducing a controlled and reproducible coagulative necrosis. In addition, the photo-coagulative effect reduces the bleeding risk.…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, several studies have demonstrated that results improve with experience. 12 - 14 The visualization of the target area during the procedure can be difficult due to tissue vaporization and an incorrect positioning of the laser needle-fiber can invalidate the treatment goal. Thus, the radiologist should have a long experience in breast interventional procedures and excellent manual skills.…”

Section: Discussionmentioning

confidence: 99%

“…The ablation rate rises between 84 and 100% if only small breast lesions are considered. [12][13][14][15] Moreover, there are also studies on the laser thermal ablation of benign lesions, such as fibroadenomas 16,17 or as palliative therapy in inoperable or refusing surgery patients. 18 It is also important underline that LITT has already been widely standardized in several studies in the literature, both ex-vivo and in-vivo, on brain, bone, skin, gastrointestinal, liver, lung, pancreas, thyroid, retinal lesions, prostate and uterus [19][20][21][22][23][24][25][26] ; however the validation of tumor ablate therapy in breast clinical practice is still ongoing, more prospective studies addressing local failure rates, cosmesis, the effectiveness to detect residual untreated disease, and long-term patient satisfaction are required.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ultrasound-Guided Laser Ablation After Excisional Vacuum-Assisted Breast Biopsy for Small Malignant Breast Lesions: Preliminary Results

Perretta

Meucci

Pistolese

et al. 2021

Technol Cancer Res Treat

View full text Add to dashboard Cite

Background: The purpose of this preliminary study is to evaluate the feasibility of the excisional ultrasound (US) guided vacuum-assisted breast biopsy (VAE), followed by US-guided Laser Interstitial Thermal Therapy (LITT) in the treatment of unifocal ductal breast carcinomas ≤ 1 cm and estimate the ablation rate analyzing the final histopathological results after subsequent surgical excision. Methods: In a single session 11 female patients with unifocal less than a centimeter breast cancer underwent 2 different minimally invasive percutaneous US-guided techniques: a VAE breast biopsy with an 8 G needle to remove the lesion and, immediately after, a LITT ablation in the biopsy site. Four weeks later, all patients underwent radiological follow-up. Afterward, a systematic surgery was performed, the ablation rate was calculated, and iconographic and histological features were correlated. Results: Average maximum diameter of the lesions was 7.6 mm (5-10 mm). No patient reported pain or discomfort during procedure. 1/11 patient (9.1%) reported an early minor complication (a small superficial skin burn). After surgical excision, the histopathological evaluation reported in 10/11 cases (90.9%) complete ablation of the target lesion. In only one case (9.1%) residual cancer was detected. The necrotic-hemorrhagic cavities showed a mean maximum diameter of 27.3 mm (20-35 mm). Conclusions: Laser ablation performed after excisional biopsy could be considered a valid alternative to surgical excision for the treatment of lesions ≤ 1 cm, if carried out by expert radiologists. The association of these minimally invasive percutaneous methods has proven to be reliable, fast, and safe with an ablation rate of 90.9% and excellent aesthetic results. RM and CESM are potentially able to quantifying treatment results and to follow-up the ablation effects.

show abstract