Correction to Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia

Alagaili, Abdulaziz N.; Briese, Thomas; Mishra, Nischay; Kapoor, Vishal; Sameroff, Stephen; Burbelo, Peter D.; Wit, Emmie de; Munster, Vincent; Hensley, Lisa E.; Zalmout, Iyad S.; Kapoor, Amit; Epstein, Jonathan H.; Karesh, William B.; Daszak, Peter; Mohammed, Osama B.; Lipkin, W. Ian

doi:10.1128/mbio.01002-14

Cited by 218 publications

(64 citation statements)

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“…In fact, apart from camel brucellosis, camel-to-human transmission of zoonotic agents is either rare or unsubstantiated. Nonetheless, camels have been proposed as the reservoir for the newly described Middle East respiratory syndrome coronavirus (Alagaili et al 2014, Haagmans et al 2014. Given the apparent growing scientific and public health interest in camels as potential zoonotic hosts under a ''One Health'' approach, we decided to examine the prevalence of Bartonella spp.…”

Section: Introductionmentioning

confidence: 99%

Bartonella dromedariisp. nov. Isolated from Domesticated Camels (Camelus dromedarius) in Israel

Rasis

Rudoler²,

Schwartz³

et al. 2014

Vector-Borne and Zoonotic Diseases

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Bartonella spp. are fastidious, Gram-negative bacilli that cause a wide spectrum of diseases in humans. Most Bartonella spp. have adapted to a specific host, generally a domestic or wild mammal. Dromedary camels (Camelus dromedarius) have become a focus of growing public-health interest because they have been identified as a reservoir host for the Middle East respiratory syndrome coronavirus. Nevertheless, data on camel zoonoses are limited. We aimed to study the occurrence of Bartonella bacteremia among dromedaries in Israel. Nine of 51 (17.6%) camels were found to be bacteremic with Bartonella spp.; bacteremia levels ranged from five to >1000 colony-forming units/mL. Phylogenetic reconstruction based on the concatenated sequences of gltA and rpoB genes demonstrated that the dromedary Bartonella isolates are closely related to other ruminant-derived Bartonella spp., with B. bovis being the nearest relative. Using electron microscopy, the novel isolates were shown to be flagellated, whereas B. bovis is nonflagellated. Sequence comparisons analysis of the housekeeping genes ftsZ, ribC, and groEL showed the highest homology to B. chomelii, B. capreoli, and B. birtlesii, respectively. Sequence analysis of the gltA and rpoB revealed ∼96% identity to B. bovis, a previously suggested cutoff value for sequence-based differentiation of Bartonella spp., suggesting that this approach does not have sufficient discriminatory power for differentiating ruminant-related Bartonella spp. A comprehensive multilocus sequence typing (MLST) analysis based on nine genetic loci (gltA, rpoB, ftsZ, internal transcribed spacer (ITS), 16S rRNA, ribC, groEL, nuoG, and SsrA) identified seven sequence types of the new dromedary isolates. This is the first description of a Bartonella sp. from camelids. On the basis of a distinct reservoir and ecological niche, sequence analyses, and expression of flagella, we designate these isolates as a novel Bartonella sp. named Bartonella dromedarii sp. nov. Further studies are required to explore its zoonotic potential.

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Section: Introductionmentioning

confidence: 99%

Bartonella dromedariisp. nov. Isolated from Domesticated Camels (Camelus dromedarius) in Israel

Rasis

Rudoler²,

Schwartz³

et al. 2014

Vector-Borne and Zoonotic Diseases

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“…MERS-CoV RNA has been detected in dromedary camels ( 3 , 4 ), and dromedary infection precedes human infection ( 5 ). We conducted a prospective study in dromedary herds in Al-Hasa, Saudi Arabia, through the peak calving season (December 2013–February 2014) to document virologic features of MERS-CoV infection in these animals.…”

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confidence: 99%

MERS Coronavirus in Dromedary Camel Herd, Saudi Arabia

Hemida¹,

Chu²,

Poon³

et al. 2014

Emerg. Infect. Dis.

254

353

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“…Camels are thought to be an important reservoir for MERS-CoV. Anti-MERS-CoV antibodies have been detected in samples that have been collected from dromedary camels in Saudi Arabia since 1992 [15] and the genomes of MERS-CoV viruses isolated from camels and humans are similar [16]. Phylogenetic data suggest that camels act as sources of virus for humans rather than vice versa [9].…”

mentioning

confidence: 94%

“…The spring peak corresponds to the end of camel calving season in Saudi Arabia [30], potentially suggesting a particular role for young camels in zoonotic transmission. This theory is supported by the higher frequency of infection and higher viral shedding in young camels compared with older ones [15,[31][32]. The majority of reported cases have likely occurred through contact with another case, and only about a fourth of all cases are considered as primary [19].…”

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confidence: 96%

What Needs to be Done to Control the Spread of Middle East Respiratory Syndrome Coronavirus?

Edelstein¹,

Heymann²

2015

Future Virol.

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Up to November 2014, Middle East respiratory syndrome coronavirus (MERSCoV) has infected 935 individuals and killed 371, all originating in or with links to the Middle East. The mechanisms of transmission of the disease are not fully understood, but MERS-CoV seems to sustain itself in the human population through repeated re-introduction from a camel reservoir and is able to cause nosocomial outbreaks. The risk of a global spread of MERS-CoV is low. Epidemiological, serological and phylogenetic research, combined with one health surveillance, dynamic case definitions, active case finding, rigorous infection control, culturally sensitive risk communication and a continuous re-evaluation of new evidence will enable to better understand the disease, limit its spread and quantify its risk in order to better prepare for a hypothetical spread.

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Correction to Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia

Abstract: , 2014. Author Peter D. Burbelo's name was inadvertently omitted. The byline and affiliation line should appear as shown above. Also, the following statement should be added to Acknowledgments:

Cited by 218 publications

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Bartonella dromedariisp. nov. Isolated from Domesticated Camels (Camelus dromedarius) in Israel

Bartonella dromedariisp. nov. Isolated from Domesticated Camels (Camelus dromedarius) in Israel

MERS Coronavirus in Dromedary Camel Herd, Saudi Arabia

What Needs to be Done to Control the Spread of Middle East Respiratory Syndrome Coronavirus?

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