Correction to: melatonin enhances antioxidant defenses but could not ameliorate the reproductive disorders in induced hyperthyroidism model in male rats

Ramadan, Hager M.; Taha, N.; Ahmed, Hodallah H.

doi:10.1007/s11356-020-11784-y

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“…In recent studies, it has been shown by biochemical and immunohistochemical methods that MEL affects the cardiovascular system (11,42,46). In this study, severe degeneration of endothelial cells in the intima layer, thickening of the vessel wall due to severe collagen increase in the media layer, and moderate edema in the adventitia layer were observed in the thyroxine treated group.…”

Section: Discussionsupporting

confidence: 49%

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Effects of Melatonin Administration on Vasomotor Activity and Histological Structure of Isolated Thoracic Aorta in Rats Treated with Thyroxine

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et al. 2023

Clinical and Experimental Health Sciences

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Objective: The goal of this study was to examine the effect of in vivo melatonin (MEL) administration on isolated thoracic aorta in rats with thyroxine treatment and its duty in aortic response to contractile agents, such as potassium chloride (KCl) and phenylephrine (PE). In addition, immunohistological alterations were also examined. Methods: Experimental groups were as follows: control group (n= 5), thyroxine group (n= 5), melatonin group (n= 6), and thyroxine + melatonin group (n= 6). L-thyroxine was given by intraperitoneal (i.p) administration at 0.3 mg/kg/day for 14 days. MEL was administered i.p., at 3 mg/kg/day for 14 days. The thoracic aorta was isolated from rats euthanized by cervical dislocation. Then, vascular rings were prepared. Concentration-response curves for KCl and PE applications were recorded in an isolated organ bath. Tissue samples were fixed in 10% formalin for histopathological and immunohistological evaluation. Results: KCl and PE-induced contractions were reduced significantly in the thoracic aortic rings of the thyroxine-treated rats. MEL administration partially attenuated the reduction in the contraction responses due to thyroxine treatment. Immunohistological findings showed that MEL inhibits the thickening of the vessel wall by probably suppressing collagen formation due to thyroxine treatment in the aortic tissue. Conclusion: Our results suggest that MEL may attenuate the decrease in vascular resistance caused by thyroxine treatment.

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Section: Discussionsupporting

confidence: 49%

“…Melatonin, on the other hand, suppresses T 4 released from the thyroid gland, causing a decrease in plasma T 4 levels. Melatonin also increases TSH (42). Vriend et al…”

Section: Discussionmentioning

confidence: 97%