Correction to: Iron oxides nanoparticles (IOs) exposed to magnetic field promote expression of osteogenic markers in osteoblasts through integrin alpha-3 (INTa-3) activation, inhibits osteoclasts activity and exerts anti-inflammatory action

Marycz, Krzysztof; Sobierajska, Paulina; Roecken, Michael; Kornicka, Katarzyna; Kępska, Martyna; Idczak, R.; Nédélec, Jean-Marie; Wiglusz, Rafał J.

doi:10.1186/s12951-020-00631-4

Cited by 4 publications

(6 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Study have shown that IONPs could be rapidly magnetized under exposed to an SMF, and the combination of IOPNs and SMF have a synergistically enhance or inhibit effect on the differentiation of osteoblasts and osteoclasts. 147 Marycz et al 148 showed a-Fe 2 O 3 /g-Fe 2 O 3 nanocomposite (IOs) combined with 0.2 T SMF enhance the expression of osteogenic marker OPN, OCN, and Coll-1 in MC3T3 osteoblasts by activating integrin alpha-3 (INTa-3). IONPs-loaded bovine serum albumin (Fe 3 O 4 /BSA) particles exposed to 1 T SMF enhanced ALP activity and the expressions of COL-1 and OCN, and increased the osteogenic differentiation of MSCs.…”

Section: Reviewmentioning

confidence: 99%

Recent advances of nanoparticles on bone tissue engineering and bone cells

Zhang,

Zhen,

Yang

et al. 2024

Nanoscale Adv.

View full text Add to dashboard Cite

show abstract

Section: Reviewmentioning

confidence: 99%

Recent advances of nanoparticles on bone tissue engineering and bone cells

Zhang,

Zhen,

Yang

et al. 2024

Nanoscale Adv.

View full text Add to dashboard Cite

show abstract

“…[ 201 ] It was reported that integrins, the major molecular force transducers, mediated the mechanotransduction process of magnetic nanoparticles and SMF. [ 207a ] RhoA/Rho‐associated kinase (Rho‐kinase/ROCK) and MAPK signaling pathways, which are downstream of integrins, are subsequently activated, facilitating osteogenic differentiation. [ 218 ] Meanwhile, α‐Fe 2 O 3 /γ‐Fe 2 O 3 are not only able to enhance the osteogenic activities of stem cells through activating integrin alpha‐3 (INTα‐3) [ 207a ] but also by upregulating WNT/β‐catenin signaling.…”

Section: Impact Of Magnetic Signalsmentioning

confidence: 99%

“…For example, Fe 3 O 4 was demonstrated to increase the osteogenic differentiation of MC3T3 osteoblasts significantly when exposed to a magnetic field. [ 207 ] Besides, many researchers have combined magnetic nanoparticles with other desirable scaffolds to create nanocomposites with comprehensive properties for biomedical applications. Preparation methods that have been extensively studied include selective laser sintering, [ 208 ] grafting, layer‐by‐layer assembly in combination with electrospinning techniques, [ 209 ] and co‐deposition.…”

Section: Impact Of Magnetic Signalsmentioning

confidence: 99%

“…[ 207a ] RhoA/Rho‐associated kinase (Rho‐kinase/ROCK) and MAPK signaling pathways, which are downstream of integrins, are subsequently activated, facilitating osteogenic differentiation. [ 218 ] Meanwhile, α‐Fe 2 O 3 /γ‐Fe 2 O 3 are not only able to enhance the osteogenic activities of stem cells through activating integrin alpha‐3 (INTα‐3) [ 207a ] but also by upregulating WNT/β‐catenin signaling. [ 219 ] Moreover, the BMP‐2/Smad/RUNX2 pathway was observed to be activated within BMSCs upon magnetic stimulation, as evidenced by the higher expression of its components.…”

Section: Impact Of Magnetic Signalsmentioning

confidence: 99%

See 1 more Smart Citation

Materials‐Mediated In Situ Physical Cues for Bone Regeneration

Liu,

Zhang,

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Physical cues like morphology, light, electric signal, mechanic signal, magnetic signal, and heat can be used as alternative regulators for expensive but short‐acting growth factors in bone tissue engineering to promote osteogenic differentiation and bone regeneration. As physical stimulation applied directly to the tissue cannot be focused on the bone defect area to regulate the cell behaviors and fate in situ, this limits the efficiency of precise bone regeneration. Biomaterials‐mediated in situ physical cues, as an effective strategy combining the synergistic effect of materials themselves, are put forward and studied widely to promote osteogenic differentiation and bone repair efficiently and precisely. Different types of physical cues provide different choices to better satisfy the requirements for targeted bone defect repair. In this review, the recent research about different biomaterials‐mediated physical cues accelerating osteogenesis in vitro and promoting in situ bone formation in vivo is introduced. Meanwhile, the corresponding possible mechanisms of various physical cues regulating cell responses are also discussed. This review provides useful and enlightening guidance for the utilization of intrinsically physical properties of functional materials to achieve efficient bone regeneration, leading to the design and construction of smart biomaterials for practical applications, and eventually promoting clinical translation.

show abstract

“…[ 25 ] More importantly, several studies have demonstrated that the combination of Fe 3 O 4 NPs and SMF was more effective than Fe 3 O 4 NPs or SMF alone in bone regeneration. [ 26 ] However, the exact mechanism of synergistic effects of Fe 3 O 4 NPs and SMF on osteogenesis in this context remains to be explored.…”

Section: Introductionmentioning

confidence: 99%

Precipitation‐Based Silk Fibroin Fast Gelling, Highly Adhesive, and Magnetic Nanocomposite Hydrogel for Repair of Irregular Bone Defects

Zou

Liang

Wang

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Critical-sized bone defects, especially for irregular shapes, remain a significant challenge in orthopedics. Although various biomaterials are developed for bone regeneration, their application for repair of irregular bone defects is limited by the complicated preparation procedures involved, and their lack of shape-adaptive capacity, physiological adhesion, and potent osteogenic bioactivity. In the present study, a simple strategy of precipitation by introducing tannic acid (TA) with abundant phenolic hydroxyl groups and Fe 3 O 4 nanoparticles, as metal-phenolic networks (MPN), is developed to easily prepare a fast gelling, shape-adaptive, and highly adhesive regenerated silk fibroin (RSF)/TA/Fe 3 O 4 hydrogel system that can respond to a static magnetic field (SMF). The RSF/TA/Fe 3 O 4 hydrogel exhibits sufficient adhesion in biological microenvironments and good osteogenic effect in vitro and in vivo, under an external SMF, and thus, can be applied to repair critical-sized bone defects. Moreover, bioinformatics analysis reveals that the synergistic mechanism of Fe 3 O 4 NPs and SMF on osteogenic effects can be promotion of osteoblast differentiation via activation of the cyclic guanosine monophosphate (cGMP)/ protein kinase G (PKG)/extracellular signal-regulated kinase (ERK) signaling pathway. This study provides a promising biomaterial with potential clinical application for the future treatment of (irregular) critical-sized bone defects.

show abstract

Correction to: Iron oxides nanoparticles (IOs) exposed to magnetic field promote expression of osteogenic markers in osteoblasts through integrin alpha-3 (INTa-3) activation, inhibits osteoclasts activity and exerts anti-inflammatory action

Abstract: An amendment to this paper has been published and can be accessed via the original article.

Cited by 4 publications

References 1 publication

Recent advances of nanoparticles on bone tissue engineering and bone cells

Recent advances of nanoparticles on bone tissue engineering and bone cells

Materials‐Mediated In Situ Physical Cues for Bone Regeneration

Precipitation‐Based Silk Fibroin Fast Gelling, Highly Adhesive, and Magnetic Nanocomposite Hydrogel for Repair of Irregular Bone Defects

Contact Info

Product

Resources

About