Correction to Ion-Selective Nanosensor for Photoacoustic and Fluorescence Imaging of Potassium

Lee, Chang H.; Folz, Jeff; Zhang, Wuliang; Jo, Janggun; Tan, Joel W. Y.; Wang, Xueding; Kopelman, Raoul

doi:10.1021/acs.analchem.7b04696

Cited by 2 publications

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“…[13][14][15]29 PALT is able to determine the triplet-state lifetime of the oxyphor G2 and the decay rate by varying the delay time between the pump and the probe pulses. In Figure 3, PA signals correspondent to the triplet state absorption of the G2-PAA NPs with different delays (10,20,30,40, and 50 μs, respectively) between the pump and the probe pulses are shown. Each panel shows the result for different oxygen concentrations from 2% to 20%, grouped into four ranges.…”

Section: Resultsmentioning

confidence: 99%

“…Other optical imaging modalities working in the diffusion region, although being capable of covering an entire solid tumor, cannot offer sufficient spatial resolution required for studying heterogeneous tumor microenvironment. To overcome these limitations, the emerging photoacoustic (PA) imaging technique has been recently developed for chemical imaging of tumor microenvironmental parameters such as tissue oxygen concentration. − …”

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confidence: 99%

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In Vivo Photoacoustic Lifetime Based Oxygen Imaging with Tumor Targeted G2 Polyacrylamide Nanosonophores

Lee

Folz

et al. 2019

ACS Nano

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Lifetime imaging methods using phosphorescence quenching by oxygen for molecular oxygen concentration measurement have been developed and used for non-invasive oxygen monitoring. This study reports photoacoustic (PA) oxygen imaging powered by polyacrylamide (PAAm) hydrogel nanoparticle (NP) which offer advantages including improved biocompatibility, reduced toxicity, and active tumor targeting. A known oxygen indicator, oxyphor G2, was conjugated with the matrix of the NPs, giving G2-PAA NPs, followed by PEGylation for biocompatibility and F3 surface modification for tumor targeting. Using two lasers providing pump and probe pulses, respectively, PA imaging was performed so as to quantitatively map the oxygen concentration in biological tissues in vivo, including cancer tumors and normal thigh muscles. Furthermore, via the imaging at the pump wavelength and two additional wavelengths, the accumulation of the G2-PAA NPs in the tumors were also determined. The successful imaging experiment accomplished on animal models renders a method for in vivo non-invasive imaging and assessment of hypoxic tumor microenvironments, which is critical for assessing cancer progression, metastasis, and treatment.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

In Vivo Photoacoustic Lifetime Based Oxygen Imaging with Tumor Targeted G2 Polyacrylamide Nanosonophores

Lee

Folz

et al. 2019

ACS Nano

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“…Although the only optic-based PA technique is reported to measure pH level, the nanoprobe-based functional imaging method can also be extended to other EMA techniques (e.g., TA and MMTA combined with magnetic nanoparticles) for sensing other chemical-related physiological parameters (e.g., calcium [ 126 ] and potassium [ 127 ]). From another perspective of multifunctionality, by further combining EMA techniques with other therapeutic agents, the nanoprobe becomes the therapeutic nanoparticle for broader biomedical applications.…”

Section: Biomedical Sensing Applicationmentioning

confidence: 99%

Electromagnetic–Acoustic Sensing for Biomedical Applications

Liu

Zhang

Zheng

et al. 2018

Sensors

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This paper reviews the theories and applications of electromagnetic–acoustic (EMA) techniques (covering light-induced photoacoustic, microwave-induced thermoacoustic, magnetic-modulated thermoacoustic, and X-ray-induced thermoacoustic) belonging to the more general area of electromagnetic (EM) hybrid techniques. The theories cover excitation of high-power EM field (laser, microwave, magnetic field, and X-ray) and subsequent acoustic wave generation. The applications of EMA methods include structural imaging, blood flowmetry, thermometry, dosimetry for radiation therapy, hemoglobin oxygen saturation (SO2) sensing, fingerprint imaging and sensing, glucose sensing, pH sensing, etc. Several other EM-related acoustic methods, including magnetoacoustic, magnetomotive ultrasound, and magnetomotive photoacoustic are also described. It is believed that EMA has great potential in both pre-clinical research and medical practice.

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Correction to Ion-Selective Nanosensor for Photoacoustic and Fluorescence Imaging of Potassium

Abstract: There were some typos regarding subscripts in the experimental section (page 7945 of the original manuscript) and in the Y-axis legend of Figure 5.

Cited by 2 publications

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In Vivo Photoacoustic Lifetime Based Oxygen Imaging with Tumor Targeted G2 Polyacrylamide Nanosonophores

In Vivo Photoacoustic Lifetime Based Oxygen Imaging with Tumor Targeted G2 Polyacrylamide Nanosonophores

Electromagnetic–Acoustic Sensing for Biomedical Applications

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