Correction to: G3BP1 knockdown sensitizes U87 glioblastoma cell line to Bortezomib by inhibiting stress granules assembly and potentializing apoptosis

Bittencourt, Lucas; Negreiros-Lima, Graziele L.; Sousa, Lirlândia P.; Silva, A. G.; Souza, Isabela Brescia Soares de; Ribeiro, Rosy Iara Maciel de Azambuja; Dutra, M. F.; Silva, R. F.; Dias, Ana Carolina Fialho; Soriani, Frederico Marianetti; Martins, Waleska K.; Barcelos, Lucíola da Silva

doi:10.1007/s11060-019-03276-y

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, these molecules have not been investigated in the context of GBM invasion. G3BP1 is associated with stress granule assembly and G3BP1 knockdown sensitized U87-MG cells to proteasome inhibition [ 48 ]. BCLAF1 acts in a positive feedback loop enhancing PDGFRa and EGFR signaling in high-grade glioma [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion

et al. 2023

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion

et al. 2023

View full text Add to dashboard Cite

“…Expression of KIF14 is enriched in female patient specimens 43 and KIF14 inhibition reduced cell growth and increased apoptosis in glioblastoma cell lines 44 . Knockdown of G3BP1 sensitized glioma cell lines to chemotherapy 45 .…”

Section: Discussionmentioning

confidence: 99%

Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion

Alshahrany

Jimenez-Pascual

Siebzehnrubl

2023

Preprint

View full text Add to dashboard Cite

Glioblastoma is the most lethal brain cancer in adults. These incurable tumors are characterized by profound heterogeneity, therapy resistance, and diffuse infiltration. These traits have been linked to cancer stem cells, which are important for glioblastoma tumor progression and recurrence. The fibroblast growth factor receptor 1 (FGFR1) signaling pathway is a known regulator of therapy resistance and cancer stemness in glioblastoma. FGFR1 expression shows intertumoral heterogeneity and higher FGFR1 expression is associated with a significantly poorer survival in glioblastoma patients. The role of FGFR1 in tumor invasion has been studied in many cancers, but whether and how FGFR1 mediates glioblastoma invasion remains to be determined. Here, we investigated the distribution and functional relevance of FGFR1 and FGFR2 in human glioblastoma xenograft models. We found FGFR1, but not FGFR2, expressed in invasive glioblastoma cells. Loss of FGFR1, but not FGFR2, significantly reduced cell migration in vitro and tumor invasion in human glioblastoma xenografts. Comparative analysis of RNA-sequencing data of FGFR1 and FGFR2 knockdown glioblastoma cells revealed a FGFR1-specific gene regulatory network associated with tumor invasion. Our study reveals new gene candidates linked to FGFR1-mediated glioblastoma invasion.

show abstract

“…Target gene - miRNA regulatory network was constructed for up and down regulated genes. Target genes such as WEE1 [229] and G3BP1 [230] were responsible for development of GBM. RAB11FIP4 was linked with invasion of colon cancer cells [231], but this gene was identified first time in GBM and may be liable for invasion of GBM cells.…”

Section: Discussionmentioning

confidence: 99%

Identification of Key Genes and Signaling Pathways Associated with the Progression of Glioblastoma multiform

Vastrad¹,

Vastrad²,

Kotturshetti

2020

Preprint

View full text Add to dashboard Cite

Genomic features have been gradually regarded as part of the basics to the clinical diagnosis, prognosis and treatment for glioblastoma multform (GBM). However, the molecular modifications taking place during the advancement of GBM remain unclear. Therefore, recognition of potential important genes and pathways in the gastric cancer progression is important to clinical practices. In the present study, gene expression dataset (GSE116520) of GBM were selected from the Gene Expression Omnibus (GEO) database and were further used to identify differentially expressed genes (DEGs). Then, pathway and Gene Ontology (GO) enrichment analyses were conducted, and a protein-protein interaction (PPI) network was constructed to explore the potential mechanism of GBM carcinogenesis. Significant modules were discovered using the PEWCC1 plugin for Cytoscape. In addition, a target gene - miRNA regulatory network and target gene - TF regulatory network in GBM were constructed using common deregulated miRNAs, TFs and DEGs. Finally, we carried on validation of hub genes by UALCAN, cBioporta, human protein atlas, ROC (Receiver operating characteristic) curve analysis, RT-PCR and immune infiltration analysis. The results indicated that a total of 947 differential expressed genes (DEGs) (477 up regulated and 470 down regulated) was identified in microarray profiles. Pathway enrichment analysis revealed that DEGs (up and down regulated) were mainly associated in reactive oxygen species degradation, ribosome, homocarnosine biosynthesis and GABAergic synapse, whereas GO enrichment analyses revealed that DEGs (up and down regulated) were mainly associated in macromolecule catabolic process, cytosolic part, synaptic signaling and synapse part as the main pathways associated in these processes. Finally, we filtered out hub genes, including MYC, ARRB1, RPL7A, SNAP25, SOD2, SVOP, ABCC3 and ABCA2, from the all networks. Validation of hub genes suggested the robustness of the above results. In conclusion, these results provided novel and reliable biomarkers for GBM, which will be useful for further clinical applications in GBM diagnosis, prognosis and targeted therapy.

show abstract

Correction to: G3BP1 knockdown sensitizes U87 glioblastoma cell line to Bortezomib by inhibiting stress granules assembly and potentializing apoptosis

Cited by 3 publications

References 0 publications

Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion

Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion

Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion

Identification of Key Genes and Signaling Pathways Associated with the Progression of Glioblastoma multiform

Contact Info

Product

Resources

About