Correction to: Epilepsy related multimorbidity, polypharmacy and risks in adults with intellectual disabilities: a national study

Sun, James J.; Perera, Bhathika; Henley, William; Angus‐Leppan, Heather; Sawhney, Indermeet; Watkins, Lance; Purandare, Kiran; Eyeoyibo, Mogbeyiteren; Scheepers, Mark; Lines, Geraldine; Winterhalder, Robert; Ashby, Samantha; Silva, Ravindu De; Miller, Jonjo; Philpott, David E.; Ashwin, Chris; Howkins, Joshua; Slater, Harriet; Medhurst, David; Shankar, Rohit

doi:10.1007/s00415-022-11012-2

Cited by 1 publication

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Data from the Epilepsy in Intellectual Disability (Epi-IDNA) study was used to form the control group. Epi-IDNA was a cross-sectional national study investigating epilepsy related multimorbidity, polypharmacy and seizure risk in adults with intellectual disability [18]. The Epi-IDNA protocol was a consensus questionnaire developed by specialists in epilepsy and intellectual disabilities in consultation with experts by experience.…”

Section: Controlsmentioning

confidence: 99%

“…The Epi-IDNA protocol was a consensus questionnaire developed by specialists in epilepsy and intellectual disabilities in consultation with experts by experience. Participating centres for the study had identified eligible cases through automated and manual searches of electronic health records between October 2019 and June 2020 [18].…”

Section: Controlsmentioning

confidence: 99%

“…Data on demographics, health background, epilepsy profile, medications and epilepsy mortality/SUDEP risk factors were collected as with our previous study using the validated SUDEP and Seizure Safety checklist [18,19]. Data from each centre were entered into a secure electronic database: Research Electronic Data Capture (REDCap) to allow pooled analysis [20].…”

Section: Cases and Data Collectionmentioning

confidence: 99%

See 2 more Smart Citations

Mortality risk in adults with intellectual disabilities and epilepsy: an England and Wales case–control study

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background People with epilepsy (PWE) and people with intellectual disabilities (ID) both live shorter lives than the general population and both conditions increase the risk of death further. We aimed to measure associations between certain risk factors for death in PWE and ID. Methods A retrospective case-control study was conducted in ten regions in England and Wales. Data were collected on PWE registered with secondary care ID and neurology services between 2017 and 2021. Prevalence rates of neurodevelopmental, psychiatric and medical diagnoses, seizure frequency, psychotropic and antiseizure medications (ASM) prescribed, and health activity (epilepsy reviews/risk assessments/care plans/compliance etc.) recorded were compared between the two groups. Results 190 PWE and ID who died were compared with 910 living controls. People who died were less likely to have had an epilepsy risk assessment but had a greater prevalence of genetic conditions, older age, poor physical health, generalized tonic-clonic seizures, polypharmacy (not ASMs) and antipsychotic use. The multivariable logistic regression for risk of epilepsy-related death identified that age over 50, medical condition prevalence, antipsychotic medication use and the lack of an epilepsy review in the last 12 months as associated with increased risk of death. Reviews by psychiatrists in ID services was associated with a 72% reduction in the odds of death compared neurology services. Conclusions Polypharmacy and use of antipsychotics may be associated with death but not ASMs. Greater and closer monitoring by creating capable health communities may reduce the risk of death. ID services maybe more likely to provide this holistic approach. James J. Sun, Lance Watkins have contributed equally to this work.

show abstract

Section: Controlsmentioning

confidence: 99%

Section: Controlsmentioning

confidence: 99%