Correction to “Effective Delivery of siRNA into Cancer Cells and Tumors Using Well-Defined Biodegradable Cationic Star Polymers”

Abstract

Figure 1. Synthesis of poly(DMAE-MA) biodegradable cationic star polymers. (A) A schematic diagram showing the synthesis steps required to produce the cationic star polymer: (i) synthesis of P(DMAE-MA) homopolymer arm; (ii) chain extension of P(DMAE-MA) in the presence of N,N′-bis(acryloyl)cystamine and DMAE-A. (B) 1 H NMR spectrum of the purified star polymer after quaternization with HCl (recorded in D 2 O). (C) GPC traces of (orange line) P(DMAE-MA) arm, (blue line) unpurified star polymer 3 (before quaternization), and (red line) star polymer 3 (before quaternization) after precipitation in diethyl ether/petroleum ether mixture (80/20 v/v).

A fluorescence strategy for direct quantification of arm components in mikto-arm star copolymers

“…Therefore, the number and arm length of the cationic arm species of multicomponent star polymers are the key factors in evaluating the siRNA carrying efficiency. [39][40][41] However, the arm component in the final star won't be the same as planned. In the reinitiation process of RDRP, the arm species competes in the core crosslinking or coupling reaction process; thus the final composition can't be exactly the same as the feed ratio.…”