Correction to: ‘Dynamical modelling of secondary metabolism and metabolic switches in Streptomyces xiamenensis 318’

Bursts in biosynthetic gene cluster transcription are accompanied by surges of natural compound production in the myxobacteriumSorangiumsp

“…Notably, the depletion of phosphate (Martín, 2004; Thomas et al, 2012), nitrogen (Voelker & Altaba, 2001), or carbon sources (Sánchez et al, 2010), among other stress factors, was identified to stimulate the biosynthesis of antibiotics and other ‘secondary metabolites’ (van Wezel & McDowall, 2011; Wohlleben et al, 2017). In Streptomyces spp., the transcriptional activity of genes encoding enzymes for synthesizing natural compounds was mostly observed at later stages of batch cultivation, after nutrients had been depleted, whereas it was repressed during exponential bacterial growth (Nieselt et al, 2010; X.-M. Zhu et al, 2019). It is not clear, however, to what extent a generalization of this observation from actinobacteria is justified for other microorganisms, since, for example, myxobacteria produce several natural compounds preferably during growth in nutrient-rich media (Gerth et al, 1982; Kegler et al, 2006; Kunze et al, 1984; Rachid et al, 2007).…”

“…Investigations into the cellular regulation of BGC activities could facilitate control over the production of novel bioactive compounds, either by targeted molecular manipulation (Mungan et al, 2022; van der Heul et al, 2018) or by providing suitable extracellular cues (Okada & Seyedsayamdost, 2017). Transcriptional activities of BGCs and their regulation have been studied in Streptomyces (Hwang et al, 2019; Nieselt et al, 2010; X.-M. Zhu et al, 2019) and related actinobacteria (Tocchetti et al, 2015), and in a few other model organisms (Neubacher et al, 2020; Wu et al, 2020). Insights into genetic regulatory circuits of natural compound synthesis in myxobacteria are more limited at present.…”