Correction to: Development and validation of a risk score to assist screening for acute HIV-1 infection among men who have sex with men

Dijkstra, Maartje; Bree, Godelieve J. de; Stolte, Ineke G.; Davidovich, Udi; Sanders, Eduard J.; Prins, Maria; Loeff, Maarten F. Schim van der

doi:10.1186/s12879-017-2805-y

Cited by 2 publications

(2 citation statements)

References 1 publication

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“…MSM are eligible to participate in our pilot study if they (1) are 18 years or older, (2) are assigned male at birth, (3) ever had anal intercourse with a man, 3) have HIV-uninfected by a laboratory rapid antibody test, (4) are going to reside in Jiangsu province and Qingdao city in the following 6 months after recruitment, (5) own a smartphone with Android-based operating system, (6) can access the WeChat app during the study period, and (7) are able and willing to provide electronic informed consent. Exclusion criteria include (1) self-reporting concomitant use of HIV PrEP at study entry, (2) creatinine clearance <30 ml/min, (3) known co-infection with chronic hepatitis B at enrollment, (4) participating in another research intervention related to PEP, (5) mental health disorders that may compromise adherence or safety, such as memory loss, cognition impairment, or communication disorders (assessed by an experienced clinical psychologist who is not involved in the study), and (6) presence of acute HIV infection symptoms [assessed by the Amsterdam score ( 31 )].…”

Section: Methodsmentioning

confidence: 99%

An integrated online-to-offline model for HIV post-exposure prophylaxis (O2O-PEP) scale-up among men who have sex with men (MSM): Protocol for developing a pilot randomized controlled trial

Luo

et al. 2022

Front. Public Health

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BackgroundHIV post-exposure prophylaxis (PEP) is an evidence-based biomedical HIV prevention strategy consisting of a 28-day course of highly active antiretroviral therapy after recent potential exposure to HIV. However, awareness and uptake of PEP among men who have sex with men (MSM) are very low. Innovative and effective methods are needed to support PEP implementation among MSM. This work reports a protocol to design and evaluate an online-to-offline-based delivery model for HIV PEP uptake (O2O-PEP) in Chinese MSM.Methods and analysisThis will be a two-phase study. In phase 1, we will develop an O2O-PEP model delivered through the WeChat mini-app (an app built into the WeChat platform). The O2O-PEP model initially includes four core components: a gamification-based education package for PEP, an online HIV risk assessment tool, a free online booking system for PEP initiation, and offline PEP prescription in the study hospitals. In phase 2, a two-arm pilot stratified randomized controlled trial comparing the O2O-PEP group with the standard care group will be designed to assess the feasibility, usability, and preliminary evidence of the efficacy of the O2O-PEP model in increasing PEP uptake among Chinese MSM. Model feasibility and usability will be further explored for broader model implementation.DiscussionThe O2O-PEP model is one of the first interventions in China aiming to promote PEP initiation in Chinese MSM. Components in the O2O-PEP model could assist MSM in better understanding their HIV infection risk and increasing accessibility of PEP. Moreover, coupled with online and offline recruitment, the O2O-PEP model has great potential to reach and engage MSM who are not involved in care by traditional methods.Clinical trial registrationNo. ChiCTR2200062538.

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Section: Methodsmentioning

confidence: 99%

An integrated online-to-offline model for HIV post-exposure prophylaxis (O2O-PEP) scale-up among men who have sex with men (MSM): Protocol for developing a pilot randomized controlled trial

Luo

et al. 2022

Front. Public Health

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“…Viral load testing of seronegative individuals with recent risk of exposure is the most reliable way to identify a very early (acute) infection, and, despite proposals of clinical algorithms to screen eligible patients 7 , costs and logistic issues limits routine use. Identifying incident cases with information available at routine admissions to health services in low-and middle-income countries may provide a practical and useful tool to help public health policies to target segments of the population which are more vulnerable to HIV infection, thus improving diagnosis, linkage to care, and providing epidemiological information relevant to the understanding of the HIV epidemic.…”

Section: Introductionmentioning

confidence: 99%

Recent HIV infections: evaluation of a simple identification score for newly diagnosed patients

Matsuda¹,

Ahagon

Coelho

et al. 2022

Rev. saúde pública

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OBJECTIVE: Recognize incident infection to better characterize the groups that fuel HIV epidemic. We propose a simple score to identify recent infections among newly diagnosed patients as a HIV surveillance tool. METHODS: Newly diagnosed patients were defined as recent infections when a negative serological test in the previous year was available. Laboratory tests, such as the avidity index (Bio-Rad, according to the CEPHIA protocol), chemiluminescent intensity (CMIA, architect, Abbott), and the nucleotide ambiguity index of partial pol sequences were used as proxies of recency. A simple score based on clinical symptoms of acute retroviral syndrome during the previous year, CD4+ T cell count, and viral load at admission was tested to assess the predictive power, using receiver operating characteristic (ROC) curves, to identify recent cases of infection. RESULTS: We evaluated 204 recently diagnosed patients who were admitted to the Ambulatório de Referência em Moléstias Infecciosas de Santo André (Santo André Reference Infectious Diseases Outpatient Clinic), in the metropolitan region of São Paulo, Brazil, recruited between 2011 and 2018. An HIV-negative test in the year prior to enrollment was documented in 37% of participants. The proportion of cases classified as recent infections (less than one year), according to the laboratory proxies were: 37% (67/181) for an avidity index < 40%, 22% (30/137) for a CMIA < 200, and 68% (124/181) for an ambiguity index < 0.5%. Using different combinations of recency definitions, our score showed an area under the ROC curve from 0.66 to 0.87 to predict recency. CONCLUSIONS: Using data from patients’ interviews and routine laboratory tests at admission, a simple score may provide information on HIV recency and thus, a proxy for HIV incidence to guide public policies. This simple for the Brazilian public health system and other low- and middle-income countries.

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Correction to: Development and validation of a risk score to assist screening for acute HIV-1 infection among men who have sex with men

Cited by 2 publications

References 1 publication

An integrated online-to-offline model for HIV post-exposure prophylaxis (O2O-PEP) scale-up among men who have sex with men (MSM): Protocol for developing a pilot randomized controlled trial

An integrated online-to-offline model for HIV post-exposure prophylaxis (O2O-PEP) scale-up among men who have sex with men (MSM): Protocol for developing a pilot randomized controlled trial

Recent HIV infections: evaluation of a simple identification score for newly diagnosed patients

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