Correction to: Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T-cell immunity

Tchekneva, Elena E.; Goruganthu, Mounika U.L.; Uzhachenko, Roman V.; Thomas, Portia L.; Antonucci, Anneliese; Chekneva, Irina; Koenig, Michael J.; Piao, Longzhu; Akhter, Anwari; Aquino, Maria Teresa P. de; Ranganathan, Paravathi; Long, Nicholas; Magliery, Thomas J.; Valujskikh, Anna; Evans, Jason V.; Arasada, Rajeswara Rao; Massion, Pierre P.; Carbone, David P.; Shanker, Anil; Dikov, Mikhail M.

doi:10.1186/s40425-019-0592-2

Cited by 6 publications

(7 citation statements)

References 1 publication

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“…Tissue tissue-specific genetic ablation of Jagged1 and systemic administration of soluble inhibitory JAG1 provided further proof of ligand-mediated Notch activation in T regs (6). CD11c-specific ablation of JAG2 did not have any effects on IFN-γ production but significantly decreased IL-4 production by activated T cells.…”

Section: Regulatory T Cell Functions Can Be Modulated In a Jag1-specimentioning

confidence: 93%

“…Studies have demonstrated that endogenous Notch ligandreceptor interactions can be selectively blocked or enhanced to influence signaling in tumoral, stromal and immune compartments (5,6,85,86). Although receptor-ligand interactions can be abrogated using blocking antibodies, this presents some limitations including high costs, low tissue penetration, unclear mode of action in vivo, cytotoxicity, and affinity for inhibitory Fc receptors which reduces their overall efficacy (87).…”

Section: Novel Notch Modulatory Agents Engineered Ligand-specific Thementioning

confidence: 99%

“…Full-length or partial extracellular domains of Notch ligands could be also be used to modulate ligand-specific Notch signaling events. Soluble monomeric fragments comprised of the DSL and first two EGF repeats of DLL1 (sDLL1) and the first five N-terminal domains of JAG1 (sJAG1 N−E3 ) could selectively inhibit Notch1-DLL1 and Notch1-JAG1 interactions, respectively (6). The sDLL1 fragment attenuated in vitro T cell proliferation in cocultures with DLL1-bearing dendritic cells, indicating its potential ability to impair T cell responses by blocking endogenous DLL1.…”

Section: Novel Notch Modulatory Agents Engineered Ligand-specific Thementioning

confidence: 99%

“…Findings from murine models of solid tumors, allergic responses and autoimmune disorders indicate great potential for the clinical application of Notch ligands and their derivatives as immunomodulatory agents for the management of malignant cancers (4,5). Engineered Notch ligand-derived moieties could be used to induce desired immune responses and boost antitumor immunity (6,7).…”

Section: Introductionmentioning

confidence: 99%

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Specific Targeting of Notch Ligand-Receptor Interactions to Modulate Immune Responses: A Review of Clinical and Preclinical Findings

et al. 2020

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Understanding and targeting Notch signaling effectively has long been valued in the field of cancer and other immune disorders. Here, we discuss key discoveries at the intersection of Notch signaling, cancer and immunology. While there is a plethora of Notch targeting agents tested in vitro, in vivo and in clinic, undesirable off-target effects and therapy-related toxicities have been significant obstacles. We make a case for the clinical application of ligand-derived and affinity modifying compounds as novel therapeutic agents and discuss major research findings with an emphasis on Notch ligand-specific modulation of immune responses.

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Section: Regulatory T Cell Functions Can Be Modulated In a Jag1-specimentioning

confidence: 93%

Section: Novel Notch Modulatory Agents Engineered Ligand-specific Thementioning

confidence: 99%

Section: Novel Notch Modulatory Agents Engineered Ligand-specific Thementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Specific Targeting of Notch Ligand-Receptor Interactions to Modulate Immune Responses: A Review of Clinical and Preclinical Findings

et al. 2020

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“…A vast body of research demonstrates that the full potential of lymphocyte effector function is acquired following communications between the components of innate and adaptive immunity organized into an architecture of an interactive social network (1). For example, besides classical T-DC interactions (2)(3)(4)(5), an interplay between dendritic cells (DC) and NK cells (6,7), or T-cells and NK cells (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), plays important roles in resolving infections, solid cancers, or other pathologies. NK-T-regulatory (Treg) cell interplay maintains liver homeostasis (18).…”

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confidence: 99%

Editorial: Lymphocyte Functional Crosstalk and Regulation

2019

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Weaning causes imbalanced T lymphocyte distribution and impaired intestinal immune barrier function in piglets

Dong,

Wang,

Peng

et al. 2024

Anim. Prod. Sci.

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Context The immune system of piglets is not fully developed at weaning. The immature adaptive immune system along with the change in the feed types and the living conditions make piglets susceptible to pathogenic infections, and result in diarrhoea and decreased growth. However, the underlying mechanisms require further research. Aims This study was conducted to investigate the effects of weaning on the growth performance and intestinal immune function of piglets. Methods In total, 40 piglets with similar bodyweights were selected in pairs at 21 days old and divided into the suckling group (SG, breastfed by their mothers) and weaning group (WG, weaned at 21 days old). Eight piglets from each group were randomly selected and sacrificed at 24 days (SG3 and WG3) and 28 days of age (SG7 and WG7). The growth performance, T lymphocyte subpopulations, the concentration of cytokines and immunoglobulins, and the expression of Notch2 signalling proteins were determined. Key results The weaning caused a decrease in bodyweight (P < 0.01) and the ratio of CD3+CD4+/CD3+CD8+ T cells in the thymus (P < 0.05). Compared with SG3, the concentration of secretory immunoglobulin A (sIgA) in the jejunum was decreased, and that of interleukin 2 (IL-2) in serum and ileum, IL-1β and IL-2 in jejunum were upregulated (P < 0.01), while IL-10 in the small intestine was downregulated (P < 0.05) in WG3. Weaning downregulated gene expression of IL-4 and upregulated gene expression of IL-1β, IL-12, and interferon γ (IFN-γ) in small intestine (P < 0.05). Weaning downregulated protein expression of Notch2 and Hes1 but upregulated Jagged1 expression in small intestine of piglets (P < 0.05). Conclusions Weaning caused an imbalance in T lymphocyte distribution, thus impairing the intestinal immune function of piglets, which might be associated with the Notch2 signalling. Furthermore, weaning caused adverse effects on piglets especially on the first 3 days, which were partly recovered after 3 days, but still existed at 7 days after weaning. Implications The results of this study may guide the pig-raising industry, especially for the management of piglets shortly after weaning.

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Correction to: Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T-cell immunity

Cited by 6 publications

References 1 publication

Specific Targeting of Notch Ligand-Receptor Interactions to Modulate Immune Responses: A Review of Clinical and Preclinical Findings

Specific Targeting of Notch Ligand-Receptor Interactions to Modulate Immune Responses: A Review of Clinical and Preclinical Findings

Editorial: Lymphocyte Functional Crosstalk and Regulation

Weaning causes imbalanced T lymphocyte distribution and impaired intestinal immune barrier function in piglets

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