Correction to: Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players IL-1β, IL-6, IL-15 and TNF-α

The novel coronavirus pandemic has led to morbidity and mortality throughout the world. Until now, it is a highly virulent contagion attacking the respiratory system in humans, especially people with chronic diseases and the elderly who are most vulnerable. A majority of afflicted are those suffering from cardiovascular and coronary diseases. In this review article, an attempt has been made to discuss and thoroughly review the mode of therapies that alleviate cardiac complications and complications due to hypercoagulation in patients infected with the SARS-CoV-2 virus. Presently a host of thrombolytic drugs are in use like Prourokinase, Retelapse, RhTNK-tPA and Urokinase. However, thrombolytic therapy, especially if given intravenously, is associated with a serious risk of intracranial haemorrhage, systemic haemorrhage, immunologic complications, hypotension and myocardial rupture. The effects of the SARS-CoV-2 virus upon the cardiovascular system and coagulation state of the body are being closely studied. In connection to the same, clinical prognosis and complications of thrombolytic therapy are being scrutinized. It is noteworthy to mention that myocardial oxygen supply/demand mismatch, direct myocardial cells injury and acute plaque rupture are the multiple mechanisms responsible for acute coronary syndrome and cardiac complications in Covid-19 infection. However, this review has limitations as data available in this context is limited, scattered and heterogenous that questions the reliability of the same. So, more multi-centric studies involving representative populations, carried out meticulously, could further assist in responding better to cardiac complications among Covid-19 patients.

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The Effects of the SARS-CoV-2 Virus on the Cardiovascular System and Coagulation State Leading to Cardiovascular Diseases: A Narrative Review

Bhat

Maqbool²,

Rathi

et al. 2022

INQUIRY

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Reactivación y coinfecciones virales en COVID-19: otro elemento a considerar. Revisión Sistemática

Ponce-Pincay,

Diana

2023

Kasmera

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La COVID-19 es una enfermedad que afecta a la población mundial, representando un reto social y sanitario. El SARS-CoV-2 muestra afinidad por el sistema respiratorio, por ser la puerta de entrada y el sitio primario de replicación. Aunque las manifestaciones respiratorias sean las más frecuentes, se han reportado manifestaciones gastrointestinales, renales, neurológicas, cardiacas; entre otras. Un elemento que no ha recibido en la atención que merece es la reactivación y las coinfecciones virales. Como es bien sabido, el tratamiento de COVID-19 en sus formas graves y críticas incluyen productos biológicos, corticoesteroides, ventilación mecánica y la múltiple farmacoterapia, aunado a la fisiopatología propia de la enfermedad que es caracterizada por una tormenta de citoquinas; conlleva a que se reactiven infecciones virales que se consideran latentes y crónicas, agravando aún más el cuadro clínico. En esta revisión sistemática se ha encontrado que eventos hematológicos como la leucopenia y linfopenia junto al uso desmedido de esteroides, y la larga estancia hospitalaria puede conllevar a la reactivación de virus que pertenecen a la familia Herperviridae (Virus Epstein-Barr (VEB), Citomegalovirus (CMV) y el virus del Herpes (VHS1/2)) así como virus hepatotropos (virus de la Hepatitis B (VHB) y C(VHC), que pueden complicar el pronóstico clínico

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Correction to: Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players IL-1β, IL-6, IL-15 and TNF-α

Cited by 2 publications

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The Effects of the SARS-CoV-2 Virus on the Cardiovascular System and Coagulation State Leading to Cardiovascular Diseases: A Narrative Review

The Effects of the SARS-CoV-2 Virus on the Cardiovascular System and Coagulation State Leading to Cardiovascular Diseases: A Narrative Review

Reactivación y coinfecciones virales en COVID-19: otro elemento a considerar. Revisión Sistemática

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