Correction to: Copeptin, miRNA-208, and miRNA-499 as New Biomarkers for Early Detection of Acute Coronary Syndrome

Performance of Copeptin for Early Diagnosis of Acute Coronary Syndromes: A Systematic Review and Meta-Analysis of 14,139 Patients

“…The pooled analysis of twenty-six studies showed that copeptin levels in AMI and non-AMI groups varied and amounted to 68.7 ± 74.7 versus 14.8 ± 19.9 pmol/L (SMD = 2.63; 95% CI: 2.02 to 3.24; I 2 = 99%; p < 0.001) [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][37][38][39][40][41][42][43][44][45][46]. Subanalysis by type of AMI showed that higher concentrations of copeptin in the AMI group versus no-AMIs group were Eight studies reported copeptin levels between AMI and unstable angina pectoris (UAP) groups [20,27,30,31,34,40,42,46]. Pooled analysis showed that mean copeptin levels in the AMI group were higher than in the UAP group 51.9 ± 52.5 pmol/L; 12.8 ± 19.7 pmol/L (SMD = 1.53; 95%CI: 0.86 to 2.20; I 2 = 95%; p < 0.001).…”

“…Subanalysis showed that copeptin levels were higher in the AMI group compared with the UAP group across all subgroups: STEMI (128.2 ± 91.7 vs. 11.7 ± 4.8 pmol/L respectively; SMD = 2.46; 95%CI: 2.00 to 2.92; p < 0.001), NSTEMI (41.5 ± 58.9 vs. 8.8 ± 5.6 pmol/L; SMD = 1.76; 95%CI: 1.34 to 2.18; I 2 = 51%; p < 0.001), and unspecified AMI (43.6 ± 30.1 vs. 15.2 ± 24.5 pmol/L; SMD = 1.45; 95%CI: 0.07 to 2.82; I 2 = 98%; p = 0.04; Figure 3). Eight studies reported copeptin levels between AMI and unstable angina pectoris (UAP) groups [20,27,30,31,34,40,42,46]. Pooled analysis showed that mean copeptin levels in the AMI group were higher than in the UAP group 51.9 ± 52.5 pmol/L; 12.8 ± 19.7 pmol/L (SMD = 1.53; 95% CI: 0.86 to 2.20; I 2 = 95%; p < 0.001).…”

“…Figure 1 shows the results of the search and article selection. The final set consisted of 27 eligible studies , including 6 articles conducted in Germany [23,32,34,39,40,42]; 5 articles in France [25,26,31,37,41]; 2 articles in Switzerland [36,45]; 2 articles in Egypt [20,27]; 1 from each of the following countries: Denmark [46], Iceland [44], Korea [33], USA [35], Poland [38], Sweden [43], Spain [21], The Netherlands [29], and Turkey [22]; and 2 international articles [24,28]. The total number of participants was 14,139.…”