Correction to: Chronic unpredictable mild stress produces depressive-like behavior, hypercortisolemia, and metabolic dysfunction in adolescent cynomolgus monkeys

Teng, Teng; Shively, Carol A.; Li, Xuemei; Jiang, Xiaofeng; Neigh, Gretchen N.; Yin, Bangmin; Zhang, Yuqing; Fan, Liancheng; Xiang, Yajie; Wang, Mingyang; Liu, Xueer; Qin, Mengchang; Xie, Peng

doi:10.1038/s41398-021-01251-8

Cited by 6 publications

(1 citation statement)

References 42 publications

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“…Our data demonstrate that social context matters for affective reactivity. Adult monkeys housed in different social conditions responded differently in the very same tasks that behavioral neuroscientists and psychologists use to model neuropsychiatric disorders 86 – 90 and determine the neural correlates of affective processing 54 , 55 , 58 , 59 , 63 , 75 , 91 . Adult monkeys housed individually during experiments generated different affective responses to threat compared to monkeys with social contact (either grate-, intermittently- or continuously-paired).…”

Section: Discussionmentioning

confidence: 99%

Social housing status impacts rhesus monkeys’ affective responding in classic threat processing tasks

Charbonneau

Amaral

Bliss‐Moreau

2022

Sci Rep

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Individuals’ social contexts are broadly recognized to impact both their psychology and neurobiology. These effects are observed in people and in nonhuman animals who are the subjects for comparative and translational science. The social contexts in which monkeys are reared have long been recognized to have significant impacts on affective processing. Yet, the social contexts in which monkeys live as adults are often ignored and could have important consequences for interpreting findings, particularly those related to biopsychiatry and behavioral neuroscience studies. The extant nonhuman primate neuropsychological literature has historically tested individually-housed monkeys, creating a critical need to understand how social context might impact the outcomes of such experiments. We evaluated affective responding in adult rhesus monkeys living in four different social contexts using two classic threat processing tasks—a test of responsivity to objects and a test of responsivity to an unfamiliar human. These tasks have been commonly used in behavioral neuroscience for decades. Relative to monkeys with full access to a social partner, individually-housed monkeys had blunted reactivity to threat and monkeys who had limited contact with their partner were more reactive to some threatening stimuli. These results indicate that monkeys’ social housing contexts impact affective reactivity and point to the potential need to reconsider inferences drawn from prior studies in which the impacts of social context have not been considered.

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Section: Discussionmentioning

confidence: 99%

Social housing status impacts rhesus monkeys’ affective responding in classic threat processing tasks

Charbonneau

Amaral

Bliss‐Moreau

2022

Sci Rep

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Biogeography of the large intestinal mucosal and luminal microbiome in cynomolgus macaques with depressive-like behavior

et al. 2021

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Most previous studies in the pathophysiology of major depressive disorder (MDD) focused on fecal samples, which limit the identification of the gut mucosal and luminal microbiome in depression. Here, we address this knowledge gap. Male cynomolgus macaques (Macaca fascicularis) were randomly assigned to a chronic unpredictable mild stress (CUMS) group, or to an unstressed control group. Behavioral tests were completed in both groups. At endpoint, microbe composition of paired mucosal and luminal samples from cecum, ascending, transverse, and descending colons were determined by 16S ribosomal RNA gene sequencing. The levels of 34 metabolites involved in carbohydrate or energy metabolism in luminal samples were measured by targeted metabolomics profiling. CUMS macaques demonstrated significantly more depressive-like behaviors than controls. We found differences in mucosal and luminal microbial composition between the two groups, which were characterized by Firmicutes and Bacteriodetes at the phylum level, as well as Prevotellaceae and Lachnospiraceae at the family level. The majority of discriminative microbes correlated with the depressive-like behavioral phenotype. In addition, we found 27 significantly different microbiome community functions between the two groups in mucosa, and one in lumen, which were mainly involved in carbohydrate and energy metabolism. A total of nine metabolites involved in these pathways were depleted in CUMS animals. Together, CUMS macaques with depressive-like behaviors associated with distinct alterations of covarying microbiota, carbohydrate and energy metabolism in mucosa and lumen. Further studies should focus on the mucosal and luminal microbiome to provide a deeper spatiotemporal perspective of microbial alterations in the pathogenesis of MDD.

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Evaluating depression- and anxiety-like behaviors in non-human primates

Ausderau

Colman

Kabakov

et al. 2023

Front. Behav. Neurosci.

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Depression and anxiety are some of the most prevalent and debilitating mental health conditions in humans. They can present on their own or as co-morbidities with other disorders. Like humans, non-human primates (NHPs) can develop depression- and anxiety-like signs. Here, we first define human depression and anxiety, examine equivalent species-specific behaviors in NHPs, and consider models and current methods to identify and evaluate these behaviors. We also discuss knowledge gaps, as well as the importance of evaluating the co-occurrence of depression- and anxiety-like behaviors in animal models of human disease. Lastly, we consider ethical challenges in depression and anxiety research on NHPs in order to ultimately advance the understanding and the personalized treatment of these disorders.

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Correction to: Chronic unpredictable mild stress produces depressive-like behavior, hypercortisolemia, and metabolic dysfunction in adolescent cynomolgus monkeys

Abstract: A Correction to this paper has been published: https://doi.org/10.1038/s41398-021-01251-8

Cited by 6 publications

References 42 publications

Social housing status impacts rhesus monkeys’ affective responding in classic threat processing tasks

Social housing status impacts rhesus monkeys’ affective responding in classic threat processing tasks

Biogeography of the large intestinal mucosal and luminal microbiome in cynomolgus macaques with depressive-like behavior

Evaluating depression- and anxiety-like behaviors in non-human primates

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