Correction to: Cerebellar Modules and Their Role as Operational Cerebellar Processing Units: A Consensus paper

Apps, Richard; Hawkes, Richard; Aoki, Sho; Bengtsson, Fredrik; Brown, Amanda M.; Chen, Gang; Ebner, Timothy J.; Isope, Philippe; Jörntell, Henrik; Lackey, Elizabeth P.; Lawrenson, Charlotte; Lumb, Bridget M.; Schonewille, Martijn; Sillitoe, Roy V.; Spaeth, Ludovic; Sugihara, Izumi; Valera, Antoine M.; Voogd, Jan; Wylie, Douglas R.; Ruigrok, Tom J. H.

doi:10.1007/s12311-018-0959-9

Cited by 33 publications

(36 citation statements)

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“…Cerebellar circuits are organized in repetitive parasagittal modules 47,58 . Previous studies have unequivocally established a key cerebellar pathway for DEC, in which IN neurons innervate the premotor neurons in the RN that subsequently excite the 7N motor neurons responsible for eyelid movements 42,43,57 .…”

Section: Fn-mdv and In-rn Pathways Converge Onto The 7n And Regulate Decmentioning

confidence: 99%

A Novel FN-MdV Pathway and Its Role in Cerebellar Multimodular Control of Sensorimotor Behavior

Wang

Ren

et al. 2020

Preprint

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The cerebellum is crucial for various associative sensorimotor behaviors. Delay eyeblink conditioning (DEC) depends on the simplex lobule-interposed nucleus (IN) pathway, yet it is unclear how other cerebellar modules cooperate during this task. Here, we demonstrate the contribution of the vermis-fastigial nucleus (FN) pathway in controlling DEC. We found that task-related modulations in vermal Purkinje cells and FN neurons predict conditioned responses (CRs). Coactivation of the FN and the IN allows for the generation of proper motor commands for CRs, but only FN output fine-tunes unconditioned responses. The vermis-FN pathway launches its signal via the contralateral ventral medullary reticular nucleus, which converges with the command from the simplex-IN pathway onto facial motor neurons. We propose that the IN pathway specifically drives CRs whereas the FN pathway modulates the amplitudes of eyelid closure during DEC. Thus, associative sensorimotor task optimization requires synergistic modulation of different olivocerebellar modules that provide unique contributions.

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Section: Fn-mdv and In-rn Pathways Converge Onto The 7n And Regulate Decmentioning

confidence: 99%

A Novel FN-MdV Pathway and Its Role in Cerebellar Multimodular Control of Sensorimotor Behavior

Wang

Ren

et al. 2020

Preprint

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“…Imaging fields were generally located within the top 150 m of the internal granule layer (IGL), covered an average surface area of 10,923 m 2 , were preferentially aligned with their long axis in an anteroposterior direction, and extended an average of 63 m in the mediolateral direction (range 28 -112 m). Individual FOVs were therefore likely to fall either within one module or between two adjacent modules as defined by mossy fiber terminals, which cluster in ϳ100to 150-m-wide parasagittally oriented stripes (Ji and Hawkes, 1994;Gebre et al, 2012;Huang et al, 2013;Apps et al, 2018). Two to seven FOVs were imaged per animal, suggesting that the composite dataset includes granule neurons sampled from multiple modules.…”

Section: Two-photon Microscopymentioning

confidence: 99%

Sensorimotor Coding of Vermal Granule Neurons in the Developing Mammalian Cerebellum

Markwalter

Yang²,

Holy³

et al. 2019

J. Neurosci.

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The vermal cerebellum is a hub of sensorimotor integration critical for postural control and locomotion, but the nature and developmental organization of afferent information to this region have remained poorly understood in vivo. Here, we use in vivo two-photon calcium imaging of the vermal cerebellum in awake behaving male and female mice to record granule neuron responses to diverse sensorimotor cues targeting visual, auditory, somatosensory, and motor domains. Use of an activity-independent marker revealed that approximately half (54%) of vermal granule neurons were activated during these recordings. A multikernel linear model distinguished the relative influences of external stimuli and co-occurring movements on neural responses, indicating that, among the subset of activated granule neurons, locomotion (44%-56%) and facial air puffs (50%) were more commonly and reliably encoded than visual (31%-32%) and auditory (19%-28%) stimuli. Strikingly, we also uncover populations of granule neurons that respond differentially to voluntary and forced locomotion, whereas other granule neurons in the same region respond similarly to locomotion in both conditions. Finally, by combining two-photon calcium imaging with birth date labeling of granule neurons via in vivo electroporation, we find that early-and late-born granule neurons convey similarly diverse sensorimotor information to spatially distinct regions of the molecular layer. Collectively, our findings elucidate the nature and developmental organization of sensorimotor information in vermal granule neurons of the developing mammalian brain.

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“…Action-based maps have also been found in the motor cortex, with different cortical sites responsible for ethologically relevant complex movements involving multiple muscles and joints (Graziano et al, 2002; Haiss and Schwarz, 2005; Graziano and Aflalo, 2007; Ejaz et al, 2015; Huber et al, 2020). A similar arrangement may apply to the cerebellum where populations of Purkinje cells within a subset of microzones with similar receptive fields combine to form a ‘super Purkinje cell’ to control its target group of cerebellar nuclear neurons (Apps et al, 2018) and co-ordinate multi-joint movements. We therefore believe it is essential when recording, analysing and interpreting activity patterns of single units in the paravermal part of the cerebellum, to take into consideration its microzonal organization.…”

Section: Discussionmentioning

confidence: 99%

Action-based organization and function of cerebellar cortical microcircuits

Cerminara

Garwicz

Darch

et al. 2020

Preprint

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The cerebellum is the largest sensorimotor structure in the brain, but its mode of operation is not well understood. However, a fundamental organizational feature of the cerebellar cortex is division into elongated zones, defined by their inputs from specific parts of the inferior olive and Purkinje cell output to cerebellar and vestibular nuclei. Little is known about how the pattern of neuronal activity in zones, and their functional microcircuit subdivisions, microzones, is related to behaviour in awake animals. Here, we studied the organization of microzones within the C3 zone and their activity during a skilled forelimb reaching task in cats. Neurons in different parts of the C3 zone, functionally determined by receptive field characteristics, differed in their patterns of activity during movement. Our results suggest that the cerebellar C3 zone is organized and operates within an action-based frame of reference, with different microcircuits within the zone controlling specific muscle synergies.

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Correction to: Cerebellar Modules and Their Role as Operational Cerebellar Processing Units: A Consensus paper

Cited by 33 publications

References 0 publications

A Novel FN-MdV Pathway and Its Role in Cerebellar Multimodular Control of Sensorimotor Behavior

A Novel FN-MdV Pathway and Its Role in Cerebellar Multimodular Control of Sensorimotor Behavior

Sensorimotor Coding of Vermal Granule Neurons in the Developing Mammalian Cerebellum

Action-based organization and function of cerebellar cortical microcircuits

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