Correction to: Cellulase Hyper‑Producing Fungus Penicillium janthinellum NCIM 1366 Elaborates a Wider Array of Proteins Involved in Transport and Secretion, Potentially Enabling a Diverse Substrate Range

Christopher, Meera; Sreeja-Raju, AthiraRaj; Kooloth-Valappil, Prajeesh; Gokhale, D. V.; Sukumaran, Rajeev K.

doi:10.1007/s12155-022-10476-4

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“…7-dehydrobrefeldin A (5) and brefeldin A (2) were isolated from P. janthinellum MPT-25 [36]. Two new brefeldin A dimers, dibrefeldins A (11) and B (12), six new derivatives, brefeldin F (13), brefeldin G (14), and 14-hydroxy-BFA (15), BFA seco-acid (16), seco-BFA methyl ester (17) and 10,11-epoxy-BFA (18) and four known products, brefeldin A (2), 7-dehydro-BFA seco-acid (19), 4-epi-BFA (20) and 6α-hydroxy-brefeldin C (21), were separated from P. janthinellum, a soil-divided fungus collected in Chongqing, China [37]. Compounds 11 and 12 were the first documented examples of dimerization through esterification of individual monomers of brefeldins A.…”

Section: Introductionmentioning

confidence: 99%

Penicillium janthinellum: A Potential Producer of Natural Products

Wang,

Li,

Wang

et al. 2024

Fermentation

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Penicillium is a kind of common filamentous fungi yielding high levels of secondary metabolites with diverse structures and attractive activities. Among these fungi, Penicillium janthinellum is a potential producer of secondary metabolites whose natural products have been noticed due to their various chemical structures and biological activities. This review summarizes the sources, distribution, bioactivities and structural characteristics of compounds isolated from P. janthinellum from 1980 to 2023. A total of 153 natural products have been isolated from P. janthinellum, of which 65 were new compounds. The compounds separated from P. janthinellum exhibit diverse skeletal chemical structures, concentrated in the categories of polyketides (40%), alkaloids (31%) and terpenoids (14%). P. janthinellum-derived compounds display attractive biological activities, such as cytotoxic, antibacterial, antifungal and antiviral activities. These results indicate that P. janthinellum is a potential fungus for producing bioactive secondary metabolites which can be used as precursors for new drugs.

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