Correction to: Budding yeast Rad51: a paradigm for how phosphorylation and intrinsic structural disorder regulate homologous recombination and protein homeostasis

Woo, Tai-Ting; Chuang, Chi-Ning; Wang, Ting-Fang

doi:10.1007/s00294-021-01161-8

Cited by 2 publications

(1 citation statement)

References 68 publications

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“…Rad51 mediates the HR repair both in mitosis and meiosis [ 29 ]. However, because of the early embryonic lethality of constitutive RAD51 knockout mice, the importance of RAD51 in spermatogenesis has not been fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

RAD51 is essential for spermatogenesis and male fertility in mice

et al. 2022

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The recombinase RAD51 catalyzes the DNA strand exchange reaction in homologous recombination (HR) during both mitosis and meiosis. However, the physiological role of RAD51 during spermatogenesis remains unclear since RAD51 null mutation is embryonic lethal in mice. In this study, we generated a conditional knockout mouse model to study the role of RAD51 in spermatogenesis. Conditional disruption of RAD51 in germ cells by Vasa-Cre led to spermatogonial loss and Sertoli cell-only syndrome. Furthermore, tamoxifen-inducible RAD51 knockout by UBC-CreERT2 confirmed that RAD51 deletion led to early spermatogenic cells loss and apoptosis. Notably, inducible knockout of RAD51 in adult mice caused defects in meiosis, with accumulated meiotic double-strand breaks (DSBs), reduced numbers of pachytene spermatocytes and less crossover formation. Our study revealed an essential role for Rad51 in the maintenance of spermatogonia as well as meiotic progression in mice.

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Section: Discussionmentioning

confidence: 99%

RAD51 is essential for spermatogenesis and male fertility in mice

et al. 2022

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Complete Genome Sequences and Genome-Wide Characterization of Trichoderma Biocontrol Agents Provide New Insights into their Evolution and Variation in Genome Organization, Sexual Development, and Fungal-Plant Interactions

Lin

Chen

et al. 2021

Microbiol Spectr

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Telomere-to-telomere and gapless reference genome assemblies are necessary to ensure that all genomic variants are studied and discovered, including centromeres, telomeres, AT-rich blocks, mating type loci, biosynthetic, and metabolic gene clusters. Here, we applied long-range sequencing technologies to determine the near-completed genome sequences of four widely used biocontrol agents or biofertilizers: Trichoderma virens Gv29-8 and FT-333, Trichoderma asperellum FT101, and Trichoderma atroviride P1.

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Correction to: Budding yeast Rad51: a paradigm for how phosphorylation and intrinsic structural disorder regulate homologous recombination and protein homeostasis

Abstract: The article: Budding yeast Rad51: a paradigm for how phosphorylation and intrinsic structural disorder regulate homologous recombination and protein homeostasis.

Cited by 2 publications

References 68 publications

RAD51 is essential for spermatogenesis and male fertility in mice

RAD51 is essential for spermatogenesis and male fertility in mice

Complete Genome Sequences and Genome-Wide Characterization of Trichoderma Biocontrol Agents Provide New Insights into their Evolution and Variation in Genome Organization, Sexual Development, and Fungal-Plant Interactions

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