Correction to: Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Joyce, Kieran; Fabra, Georgina Targa; Bozkurt, Yagmur; Pandit, Abhay

doi:10.1038/s41392-021-00593-5

Cited by 6 publications

(6 citation statements)

References 2 publications

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“…Additionally, when compared to both the control and CT groups, the CTM group exhibited the most complete epidermal layer and the densest dermal layer. The degraded collagen protein could activate ERK and MAPK signaling pathways by binding to cell surface integrins, promoting cell adhesion, survival, and migration, and promoting the healing of diabetic skin wounds . On day 21 after surgery, the epidermal layer had been fully regenerated in all groups.…”

Section: Resultsmentioning

confidence: 95%

“…The degraded collagen protein could activate ERK and MAPK signaling pathways by binding to cell surface integrins, promoting cell adhesion, survival, and migration, and promoting the healing of diabetic skin wounds. 36 On day 21 after surgery, the epidermal layer had been fully regenerated in all groups. Compared to the control and CT groups, the dermal layer of the CTM group was even denser and had skin appendages (indicated by the green arrow).…”

Section: Effect Of Collagen Dressing On Diabetic Skin Wound Healingmentioning

confidence: 88%

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Porous Collagen Sponge Loaded with Large Efficacy-Potentiated Exosome-Mimicking Nanovesicles for Diabetic Skin Wound Healing

Liu,

Zhou

et al. 2024

ACS Biomater. Sci. Eng.

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Diabetic skin wounds are difficult to heal quickly due to insufficient angiogenesis and prolonged inflammation, which is an urgent clinical problem. To address this clinical problem, it becomes imperative to develop a dressing that can promote revascularization and reduce inflammation during diabetic skin healing. Herein, a multifunctional collagen dressing (CTM) was constructed by loading large efficacy-potentiated exosomemimicking nanovesicles (L-Meseomes) into a porous collagen sponge with transglutaminase (TGase). L-Meseomes were constructed in previous research with the function of promoting cell proliferation, migration, and angiogenesis and inhibiting inflammation. CTM has a three-dimensional porous network structure with good biocompatibility, swelling properties, and degradability and could release L-Meseome slowly. In vitro experiments showed that CTM could promote the proliferation of fibroblasts and the polarization of macrophages to the anti-inflammatory phenotype. For in vivo experiments, on the 21st day after surgery, the wound healing rates of the control and CTM were 83.026 ± 4.17% and 93.12 ± 2.16%, respectively; the epidermal maturation and dermal differentiation scores in CTM were approximately four times that of the control group, and the skin epidermal thickness of the CTM group was approximately 20 μm, which was closest to that of normal rats. CTM could significantly improve wound healing in diabetic rats by promoting anti-inflammation, angiogenesis, epidermal recovery, and dermal collagen deposition. In summary, the multifunctional collagen dressing CTM could significantly promote the healing of diabetic skin wounds, which provides a new strategy for diabetic wound healing in the clinic.

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Section: Resultsmentioning

confidence: 95%

Section: Effect Of Collagen Dressing On Diabetic Skin Wound Healingmentioning

confidence: 88%

Porous Collagen Sponge Loaded with Large Efficacy-Potentiated Exosome-Mimicking Nanovesicles for Diabetic Skin Wound Healing

Liu,

Zhou

et al. 2024

ACS Biomater. Sci. Eng.

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“…Strategies aimed at interfering with cellular events driving FBR have been proposed in the design of bioactive scaffolds (Abaricia et al, 2021), including immunomodulatory biomaterials (Whitaker et al, 2021;Chen et al, 2022), functionalization of the scaffold with anti-inflammatory molecules, or with optimization and conservation of bioactive components that maximize the bioactive potential of the biomaterial (Joyce et al, 2021). Thus, the scaffold design should support cellular activity without hindering the post implantation signaling cascade.…”

Section: Introductionmentioning

confidence: 99%

“…Natural biomaterials possess bioactive properties so that biological activity can be imparted to a material using natural polymers (Joyce et al, 2021). Chitosan and alginate stand out among the vast array of natural biomaterials.…”

Section: Introductionmentioning

confidence: 99%

“…Chitosan (Cs)-a natural polysaccharide made from glucosamine and an N-acetylglucosamine moiety-is extracted from crustacean shells through deacetylation. Cs has the highest chelating capacity of all natural polymers and promotes cell adhesion, proliferation, and differentiation (Muxika et al, 2017;Joyce et al, 2021). Alginate (Alg) is a natural polysaccharide found in marine algae, which contains linked blocks of β-D-mannuronic acid (M) and α-Lguluronic acid (G) monomers (1-4).…”

Section: Introductionmentioning

confidence: 99%

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In vivo biocompatibility testing of nanoparticle-functionalized alginate–chitosan scaffolds for tissue engineering applications

Viveros-Moreno,

Garcia-Lorenzana,

Peña-Mercado

et al. 2023

Front. Bioeng. Biotechnol.

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Background: There is a strong interest in designing new scaffolds for their potential application in tissue engineering and regenerative medicine. The incorporation of functionalization molecules can lead to the enhancement of scaffold properties, resulting in variations in scaffold compatibility. Therefore, the efficacy of the therapy could be compromised by the foreign body reaction triggered after implantation.Methods: In this study, the biocompatibilities of three scaffolds made from an alginate–chitosan combination and functionalized with gold nanoparticles (AuNp) and alginate-coated gold nanoparticles (AuNp + Alg) were evaluated in a subcutaneous implantation model in Wistar rats. Scaffolds and surrounding tissue were collected at 4-, 7- and 25-day postimplantation and processed for histological analysis and quantification of the expression of genes involved in angiogenesis, macrophage profile, and proinflammatory (IL-1β and TNFα) and anti-inflammatory (IL-4 and IL-10) cytokines.Results: Histological analysis showed a characteristic foreign body response that resolved 25 days postimplantation. The intensity of the reaction assessed through capsule thickness was similar among groups. Functionalizing the device with AuNp and AuNp + Alg decreased the expression of markers associated with cell death by apoptosis and polymorphonuclear leukocyte recruitment, suggesting increased compatibility with the host tissue. Similarly, the formation of many foreign body giant cells was prevented. Finally, an increased detection of alpha smooth muscle actin was observed, showing the angiogenic properties of the elaborated scaffolds.Conclusion: Our results show that the proposed scaffolds have improved biocompatibility and exhibit promising potential as biomaterials for elaborating tissue engineering constructs.

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Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

Falsafi

Wang

Ashaolu

et al. 2022

Adv Funct Materials

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Cancer is the second leading cause of death throughout the world. Nature‐inspired anticancer agents (NAAs) that are a gift of nature to humanity have been extensively utilized in the alleviation/prevention of the disease due to their numerous pharmacological activities. While the oral route is an ideal and common way of drug administration, the application of NAAs through the oral pathway has been extremely limited owing to their inherent features, e.g., poor solubility, gastrointestinal (GI) instability, and low bioavailability. With the development of nano‐driven encapsulation strategies, polymeric vehicles, especially those with natural origins, have demonstrated a potent platform, which can professionally shield versatile NAAs against GI barricades and safely deliver them to the site of action. In this review, the predicament of orally delivering NAAs and the encapsulation strategy solutions based on biopolymer matrices are summarized. Proof‐of‐concept in vitro/in vivo results are also discussed for oral delivery of these agents by various biopolymer vehicles, which can be found so far from the literature. Last but not the least, the challenges and new opportunities in the field are highlighted.

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Correction to: Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Cited by 6 publications

References 2 publications

Porous Collagen Sponge Loaded with Large Efficacy-Potentiated Exosome-Mimicking Nanovesicles for Diabetic Skin Wound Healing

Porous Collagen Sponge Loaded with Large Efficacy-Potentiated Exosome-Mimicking Nanovesicles for Diabetic Skin Wound Healing

In vivo biocompatibility testing of nanoparticle-functionalized alginate–chitosan scaffolds for tissue engineering applications

Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

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