Correction to: BDNF Augmentation Using Riluzole Reverses Doxorubicin-Induced Decline in Cognitive Function and Neurogenesis

Usmani, Manal T.; Krattli, Robert P.; El-Khatib, Sanad M.; Le, Anh C. D.; Smith, Sarah; Baulch, Janet E.; Ng, Ding Quan; Acharya, Munjal M.; Chan, Alexandre

doi:10.1007/s13311-023-01381-5

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“…Moreover, BDNF is essential for memory consolidation [44], and its expression was evaluated in the hippocampus. The protein expression was significantly downregulated in the hippocampus of mice in the Alp group compared to the control group, further illustrating that repeated administration of Alp impairs the memory consolidation process by reducing the expression of BDNF protein.…”

Section: Alp Induces Mitochondrial Dysfunction Of Ht22 and Hippocampa...mentioning

confidence: 99%

Mitochondrial dysfunction following repeated administration of alprazolam causes attenuation of hippocampus-dependent memory consolidation in mice

Zhu,

Shi,

Jin

et al. 2023

Aging

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The frequently repeated administration of alprazolam (Alp), a highly effective benzodiazepine sedative-hypnotic agent, in anxiety, insomnia, and other diseases is closely related to many negative adverse reactions that are mainly manifested as memory impairment. However, the exact molecular mechanisms underlying these events are poorly understood. Therefore, we conducted a proteomic analysis on the hippocampus in mice that received repeated administration of Alp for 24 days. A total of 439 significantly differentially expressed proteins (DEPs) were identified in mice with repeated administration of Alp compared to the control group, and the GO and KEGG analysis revealed the enrichment of terms related to mitochondrial function, cycle, mitophagy and cognition. In vitro experiments have shown that Alp may affect the cell cycle, reduce the mitochondrial membrane potential (MMP) to induce apoptosis in HT22 cells, and affect the progress of mitochondrial energy metabolism and morphology in the hippocampal neurons. Furthermore, in vivo behavioral experiments including IntelliCage System (ICS) and nover object recognition (NOR), hippocampal neuronal pathological changes with HE staining, and the expression levels of brain-deprived neuron factor (BDNF) with immunohistochemistry showed a significant decrease in memory consolidation in mice with repeated administration of Alp, which could be rescued by the co-administration of the mitochondrial protector NSI-189. To the best of our knowledge, this is the first study to identify a link between repeated administration of Alp and mitochondrial dysfunction and that mitochondrial impairment directly causes the attenuation of memory consolidation in mice.

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Section: Alp Induces Mitochondrial Dysfunction Of Ht22 and Hippocampa...mentioning

confidence: 99%

Mitochondrial dysfunction following repeated administration of alprazolam causes attenuation of hippocampus-dependent memory consolidation in mice

Zhu,

Shi,

Jin

et al. 2023

Aging

View full text Add to dashboard Cite

show abstract

Correction to: BDNF Augmentation Using Riluzole Reverses Doxorubicin-Induced Decline in Cognitive Function and Neurogenesis

Cited by 1 publication

References 0 publications

Mitochondrial dysfunction following repeated administration of alprazolam causes attenuation of hippocampus-dependent memory consolidation in mice

Mitochondrial dysfunction following repeated administration of alprazolam causes attenuation of hippocampus-dependent memory consolidation in mice

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