Correction to: BCG revaccination of health workers in Brazil to improve innate immune responses against COVID-19: A structured summary of a study protocol for a randomised controlled trial

Junqueira-Kipnis, Ana Paula; Anjos, Laura Raniere Borges dos; Barbosa, Lília Cristina de Souza; Costa, Adeliane Castro da; Borges, Kellen Christina Malheiros; Cardoso, Amanda da Rocha Oliveira; Ribeiro, Kaio Mota; Rosa, Sarah Brena Aparecida; Souza, Carine de Castro; Neves, Rogério Coutinho das; Saraiva, Guylherme; Silva, Sueli Meira da; Silveira, Érika Aparecida; Rabahi, Marcelo Fouad; Conte, Marcus Barreto; Kipnis, André

doi:10.1186/s13063-020-04913-y

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“…It is suggested that induction of the innate immunity by Bacillus Calmette-Guerin (BCG) vaccination or previous infections could lead to protection against other (intracellular) pathogens [16,17]. BCG vaccination already showed protection against respiratory tract infections in elderly patients [18][19][20] and trials assessing the protection of BCG vaccination against SARS-CoV-2 are currently conducted [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

No Influence of Previous Coxiella burnetii Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2

Weehuizen

Spronsen

Hoepelman

et al. 2022

JCM

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Background: the geographical similarities of the Dutch 2007–2010 Q fever outbreak and the start of the 2020 coronavirus disease 19 (COVID-19) outbreak in the Netherlands raised questions and provided a unique opportunity to study an association between Coxiella burnetii infection and the outcome following SARS-CoV-2 infection. Methods: We performed a retrospective cohort study in two Dutch hospitals. We assessed evidence of previous C. burnetii infection in COVID-19 patients diagnosed at the ED during the first COVID-19 wave and compared a combined outcome of in-hospital mortality and intensive care unit (ICU) admission using adjusted odds ratios (OR). Results: In total, 629 patients were included with a mean age of 68.0 years. Evidence of previous C. burnetii infection was found in 117 patients (18.6%). The combined primary outcome occurred in 40.2% and 40.4% of patients with and without evidence of previous C. burnetii infection respectively (adjusted OR of 0.926 (95% CI 0.605–1.416)). The adjusted OR of the secondary outcomes in-hospital mortality, ICU-admission and regular ward admission did not show an association either. Conclusion: no influence of previous C. burnetii infection on the risk of ICU admission and/or mortality for patients with COVID-19 presenting at the ED was observed.

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Section: Introductionmentioning

confidence: 99%

No Influence of Previous Coxiella burnetii Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2

Weehuizen

Spronsen

Hoepelman

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

Correction to: BCG revaccination of health workers in Brazil to improve innate immune responses against COVID-19: A structured summary of a study protocol for a randomised controlled trial

Abstract: An amendment to this paper has been published and can be accessed via the original article.

Cited by 1 publication

References 1 publication

No Influence of Previous Coxiella burnetii Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2

No Influence of Previous Coxiella burnetii Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2

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