Correction to: ATP binding cassette (ABC) transporters: expression and clinical value in glioblastoma

Dréan, Antonin; Rosenberg, Shai; Lejeune, François‐Xavier; Goli, Larissa; Nadaradjane, Aravindan Arun; Guehennec, Jeremy; Schmitt, Charlotte; Verreault, Maïté; Bielle, Franck; Mokhtari, Karima; Sanson, Marc; Delattre, Jean‐Yves; Idbaïh, Ahmed

doi:10.1007/s11060-018-2830-8

Cited by 2 publications

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“…Top overlapping differentially expressed genes from our integrated analysis of bulk RNA sequencing and spatial transcriptomics have essential roles in cancer such as cell proliferation and motility. In the overlap analysis, we found the overexpression of ABCA13, PEG3, and SOX4 that have been shown to be poor prognostic markers in other cancers including ovarian, glioblastoma, and colon [ 37 , 38 , 39 , 40 ]. We observed a significant increase in FABP7 levels as measured by RNA-seq and spatial transcriptomics and validated in immunofluorescence.…”

Section: Discussionmentioning

confidence: 99%

Spatial Transcriptomics Identifies Expression Signatures Specific to Lacrimal Gland Adenoid Cystic Carcinoma Cells

Moeyersoms

Gallo

Zhang

et al. 2023

Cancers

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Although primary tumors of the lacrimal gland are rare, adenoid cystic carcinoma (ACC) is the most common and lethal epithelial lacrimal gland malignancy. Traditional management of lacrimal gland adenoid cystic carcinoma (LGACC) involves the removal of the eye and surrounding socket contents, followed by chemoradiation. Even with this radical treatment, the 10-year survival rate for LGACC is 20% given the propensity for recurrence and metastasis. Due to the rarity of LGACC, its pathobiology is not well-understood, leading to difficulties in diagnosis, treatment, and effective management. Here, we integrate bulk RNA sequencing (RNA-seq) and spatial transcriptomics to identify a specific LGACC gene signature that can inform novel targeted therapies. Of the 3499 differentially expressed genes identified by bulk RNA-seq, the results of our spatial transcriptomic analysis reveal 15 upregulated and 12 downregulated genes that specifically arise from LGACC cells, whereas fibroblasts, reactive fibrotic tissue, and nervous and skeletal muscle account for the remaining bulk RNA-seq signature. In light of the analysis, we identified a transitional state cell or stem cell cluster. The results of the pathway analysis identified the upregulation of PI3K-Akt signaling, IL-17 signaling, and multiple other cancer pathways. This study provides insights into the molecular and cellular landscape of LGACC, which can inform new, targeted therapies to improve patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Spatial Transcriptomics Identifies Expression Signatures Specific to Lacrimal Gland Adenoid Cystic Carcinoma Cells

Moeyersoms

Gallo

Zhang

et al. 2023

Cancers

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show abstract

“…ABC transporters are efflux pump proteins involved in MDR. To date, 49 members of ABC proteins have been identified to be involved in different biological mechanisms within the human body, and are classified in seven subfamilies; ABCA (12 proteins), ABCB (11 proteins), ABCC (13 proteins), ABCD (4 proteins), ABCE (1 protein), ABCF (3 proteins), and ABCG (5 proteins) (12).…”

Section: Introductionmentioning

confidence: 99%

Role of multidrug resistance in glioblastoma chemoresistance: Focus on ABC transporters

Ahmed

Verreault

Declèves

et al. 2021

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies

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Correction to: ATP binding cassette (ABC) transporters: expression and clinical value in glioblastoma

Abstract: The names of authors Marc Sanson and Jean-Yves Delattre were incorrectly presented in the initial online publication. The original article has been corrected.

Cited by 2 publications

References 0 publications

Spatial Transcriptomics Identifies Expression Signatures Specific to Lacrimal Gland Adenoid Cystic Carcinoma Cells

Spatial Transcriptomics Identifies Expression Signatures Specific to Lacrimal Gland Adenoid Cystic Carcinoma Cells

Role of multidrug resistance in glioblastoma chemoresistance: Focus on ABC transporters

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