Correction to: Antidepressant-Like Action of Single Facial Injection of Botulinum Neurotoxin A is Associated with Augmented 5-HT Levels and BDNF/ERK/CREB Pathways in Mouse Brain

Li, Yang; Liu, Jing; Liu, Xu; Su, Cunjin; Zhang, Qilin; Wang, Zhihong; Cao, Lei-Fang; Guo, Xueyan; Huang, Ya; Luo, Wei-Feng; Liu, Tong

doi:10.1007/s12264-019-00399-0

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“…Endotoxin stimulation can activate microglia and thus cause negative affective disorders [13], and microglia-derived pro-inflammatory cytokines are correlated with depression-like behaviors [14]. Furthermore, by targeting serotonin (5-HT), antidepressants inhibit depression-induced microglial activation and cytokine production, and alleviate depression-like symptoms [15][16][17]. Given that microgliainduced neuroinflammation is an important contributor to MDD, a major goal is to understand the precise underlying mechanism of microglial function in MDD.…”

Section: Introductionmentioning

confidence: 99%

Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice

Peng

et al. 2021

Neurosci. Bull.

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Microglia-mediated neuroinflammation is widely perceived as a contributor to numerous neurological diseases and mental disorders including depression. Discs large homolog 1 (Dlg1), an adaptor protein, regulates cell polarization and the function of K+ channels, which are reported to regulate the activation of microglia. However, little is known about the role of Dlg1 in microglia and the maintenance of central nervous system homeostasis. In this study, we found that Dlg1 knockdown suppressed lipopolysaccharide (LPS)-induced inflammation by down-regulating the activation of nuclear factor-κB signaling and the mitogen-activated protein kinase pathway in microglia. Moreover, using an inducible Dlg1 microglia-specific knockout (Dlg1flox/flox; CX3CR1CreER) mouse line, we found that microglial Dlg1 knockout reduced the activation of microglia and alleviated the LPS-induced depression-like behavior. In summary, our results demonstrated that Dlg1 plays a critical role in microglial activation and thus provides a potential therapeutic target for the clinical treatment of depression.

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Section: Introductionmentioning

confidence: 99%

Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice

Peng

et al. 2021

Neurosci. Bull.

View full text Add to dashboard Cite

show abstract

Correction to: Antidepressant-Like Action of Single Facial Injection of Botulinum Neurotoxin A is Associated with Augmented 5-HT Levels and BDNF/ERK/CREB Pathways in Mouse Brain

Abstract: have contributed equally to this work.The original article can be found online at https://

Cited by 1 publication

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Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice

Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice

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