Correction to: Anoikis resistant gastric cancer cells promote angiogenesis and peritoneal metastasis through C/EBPβ-mediated PDGFB autocrine and paracrine signaling

Du, Shangce; Yang, Zhi; Lu, Xiaofeng; Yousuf, Suhail; Zhao, Min; Li, Wenxi; Miao, Ji; Wang, Xingzhou; Heng, Yu; Zhu, Xinya; Chen, Hong; Shi, Linseng; Xu, En; Xia, Xuefeng; Guan, Wei

doi:10.1038/s41388-021-02096-7

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“…Zhao et al found that Twist1 was an independent factor affecting the pathological response to neoadjuvant chemotherapy for gastric cancer, and the expression of FAP in CAF was a significant factor for poor prognosis in patients with gastric cancer ( Tong et al, 2022 ; Zhao and Zhu, 2023 ). The expression of PDGFB has been reported to be closely related to tumor metastasis in patients with gastric cancer ( Han et al, 2020 ; Du et al, 2022 ). In addition, single-cell sequencing data further confirmed the high expression of RGS4 in fibroblasts.…”

Section: Discussionmentioning

confidence: 99%

Unraveling the prognostic significance of RGS gene family in gastric cancer and the potential implication of RGS4 in regulating tumor-infiltrating fibroblast

Yang,

Xing,

Luo

et al. 2024

Front. Mol. Biosci.

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Regulator of G-protein signaling (RGS) proteins are regulators of signal transduction mediated by G protein-coupled receptors (GPCRs). Current studies have shown that some molecules in the RGS gene family are related to the occurrence, development and poor prognosis of malignant tumors. However, the RGS gene family has been rarely studied in gastric cancer. In this study, we explored the mutation and expression profile of RGS gene family in gastric cancer, and evaluated the prognostic value of RGS expression. Then we established a prognostic model based on RGS gene family and performed functional analysis. Further studies showed that RGS4, as an independent prognostic predictor, may play an important role in regulating fibroblasts in the immune microenvironment. In conclusion, this study explores the value of RGS gene family in gastric cancer, which is of great significance for predicting the prognosis and guiding the treatment of gastric cancer.

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