Correction to: Accumulation, Chronicity, and Induction of Oxidative Stress Regulating Genes Through Allium cepa L. Functionalized Silver Nanoparticles in Freshwater Common Carp (Cyprinus carpio)

Rajkumar, Krishnasamy Sekar; Ramkumar, Arunachalam; Anbazhagan, Murugadas; Palaniyappan, Sivagaami; Veeran, Srinivasan; Sridhar, Arun; Ramasamy, Thirumurugan

doi:10.1007/s12011-022-03194-7

Cited by 2 publications

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“…The upregulation of SOD after 48 and 96 h can be explained by the need for gills to control the superoxide anion (O 2 •− ) concentrations. However, the SOD-catalyzed dismutation reaction consumes a large amount of SOD, and with the prolonging of exposure to Pb, the activity of antioxidant enzymes is destroyed, thus inhibiting the expression of antioxidant genes [ 70 , 71 , 72 , 73 ]. In an experiment conducted on the same species, the level of sod1 in the gills exhibited a more delayed response, peaking after 72 and 96 h of exposure to Pb [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Morphological and Functional Alterations Induced by Two Ecologically Relevant Concentrations of Lead on Danio rerio Gills

Curcio

Macirella

Sesti

et al. 2022

IJMS

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Lead (Pb), due to its high toxicity and bioaccumulation tendency, is one of the top three pollutants of concern for both humans and wildlife and occupies second place in the Priority List of Hazardous Substances. In freshwater fish, Pb is mainly absorbed through the gills, where the greatest accumulation occurs. Despite the crucial role of gills in several physiological functions such as gas exchange, water balance, and osmoregulation, no studies evaluated the effects of environmentally relevant concentrations of Pb on this organ, and existing literature only refers to high levels of exposure. Herein we investigated for the first time the molecular and morphological effects induced by two low and environmentally relevant concentrations of Pb (2.5 and 5 μg/L) on the gills of Danio rerio, a model species with a high translational value for human toxicity. It was demonstrated that Pb administration at even low doses induces osmoregulatory dysfunctions by affecting Na+/K+-ATPase and AQP3 expression. It was also shown that Pb upregulates MTs as a protective response to prevent cell damage. Modulation of SOD confirms that the production of reactive oxygen species is an important toxicity mechanism of Pb. Histological and morphometric analysis revealed conspicuous pathological changes, both dose- and time-dependent.

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