Correction: The dysbiosis signature of Fusobacterium nucleatum in colorectal cancer‑cause or consequences? A systematic review

Ranjbar, Maryam; Salehi, Roya; Javanmard, Shaghayegh Haghjooy; Rafiee, Laleh; Faraji, Habibollah; Jafarpour, Sima; Ferns, Gordon A.; Ghayour‐Mobarhan, Majid; Manian, Mostafa

doi:10.1186/s12935-022-02549-3

Cited by 2 publications

(2 citation statements)

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“…These issues are future studies that will need to try to address. Based on the important role of F. nucleatum in promoting EMT, it was found that treatment with metronidazole significantly reduced F. nucleatum load and inhibiting mCRC [ 51 ]. In addition to F. nucleatum inducing the EMT process in CRC cells, some other pathogenic bacteria, such as Enterotoxigenic B. fragilis (ETBF), E. coli , Salmonella enteric ( S. enterica ), etc., can also promote this process through various mechanisms [ 12 ].…”

Section: Mechanisms Underlying the Promotion Of Crc Metastasis By Imb...mentioning

confidence: 99%

“…F. nucleatum has also been found to affect liver immunity via the gut-liver axis: when mice were orally administered F. nucleatum , plasma levels of pro-inflammatory cytokines were significantly increased and the liver immune response was modulated, such as the recruitment of MDSCs, reduced infiltration of natural killer (NK) cells and T helper-17 (Th17) cells, and increased accumulation of regulatory T cells, resulting in significantly enhanced CRLM [ 33 ]. It is worth noting that the regulatory mechanism of F. nucleatum on NK cells is that the combination of Fap2 protein of F. nucleatum and NK Cell receptor, T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), can protect tumours from NK cells attack, thereby benefiting the survival of CRC cells [ 51 ]. Although the gut microbiota has been shown to activate HSCs to cause liver diseases, it has not been directly demonstrated that the imbalanced gut microbiota promotes CRLM by inducing the activation of HSCs [ 89 ].…”

Section: Mechanisms Underlying the Promotion Of Crc Metastasis By Imb...mentioning

confidence: 99%

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Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application

Fan,

Zhou,

Zhang

et al. 2024

Cell Commun Signal

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Metastasis poses a major challenge in colorectal cancer (CRC) treatment and remains a primary cause of mortality among patients with CRC. Recent investigations have elucidated the involvement of disrupted gut microbiota homeostasis in various facets of CRC metastasis, exerting a pivotal influence in shaping the metastatic microenvironment, triggering epithelial-mesenchymal transition (EMT), and so on. Moreover, therapeutic interventions targeting the gut microbiota demonstrate promise in enhancing the efficacy of conventional treatments for metastatic CRC (mCRC), presenting novel avenues for mCRC clinical management. Grounded in the “seed and soil” hypothesis, this review consolidates insights into the mechanisms by which imbalanced gut microbiota promotes mCRC and highlights recent strides in leveraging gut microbiota modulation for the clinical prevention and treatment of mCRC. Emphasis is placed on the considerable potential of manipulating gut microbiota within clinical settings for managing mCRC.

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Section: Mechanisms Underlying the Promotion Of Crc Metastasis By Imb...mentioning

confidence: 99%

Section: Mechanisms Underlying the Promotion Of Crc Metastasis By Imb...mentioning

confidence: 99%

Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application

Fan,

Zhou,

Zhang

et al. 2024

Cell Commun Signal

View full text Add to dashboard Cite

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Fusobacterium nucleatum Pyogenic Liver Abscess and the Role of Bacterial Virulence and Gut Microbiota Dysbiosis

Louis-Jean¹,

Agrawal²,

Bisht³

2023

Cureus

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In the United States, pyogenic liver abscesses are often due to monomicrobial infection and are rarely documented to be a consequence of Fusobacterium infection, a common cause of Lemierre's syndrome. Recent advances in gut microbial studies have identified Fusobacterium as a commensal gut flora that becomes pathogenic in the setting of dysbiosis resulting from colorectal diseases, such as diverticulitis. While the bacteria's tropism for the liver remains to be elucidated, the virulence pattern of Fusobacterium and the portal venous drainage system have allowed us to understand the bacterium's propensity for causing right hepatic abscesses. In this case report, we detail an immunocompetent man with a history of sigmoid diverticulitis who developed a right hepatic abscess due to Fusobacterium nucleatum, while delineating a review of the literature on the virulent properties of the bacterium and the impact of gut microbiota dysbiosis in its pathogenicity. A descriptive analysis was also performed to identify the characteristics of patients who are at risk in hopes of further improving the clinical diagnostic schema for this condition.

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Correction: The dysbiosis signature of Fusobacterium nucleatum in colorectal cancer‑cause or consequences? A systematic review

Cited by 2 publications

References 1 publication

Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application

Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application

Fusobacterium nucleatum Pyogenic Liver Abscess and the Role of Bacterial Virulence and Gut Microbiota Dysbiosis

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