Correction: Striatopallidal neurons control avoidance behavior in exploratory tasks

LeBlanc, Kimberly H.; London, Tanisha D; Szczot, Ilona; Bocarsly, Miriam E.; Friend, Danielle M.; Nguyen, Katrina P.; Mengesha, Marda M; Rubinstein, Marcelo; Alvarez, Veronica A.; Kravitz, Alexxai V.

doi:10.1038/s41380-019-0460-y

Cited by 2 publications

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“…center) or the elevated plus maze (i.e. open arms), does not require the EA-TS D2R signaling [34] but relies on the presence of D2R in striatopallidal neurons [97].…”

Section: Discussionmentioning

confidence: 99%

Dopamine D2 receptors in the extended amygdala scale the optimization of seeking and avoidance behaviors

Valjent

Castell²,

Gall³

et al. 2023

Preprint

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In mammals, the ability to optimize and select behavioral strategies is a cardinal and conserved psychophysiological feature for maximizing the chances of survival. However, the neural circuits and underlying mechanisms regulating this flexible feature remain yet unsolved. Here, we demonstrate that such optimization relies on dopamine D2 receptors (D2R) within a subcircuit spanning across the extended amygdala (EA) and the tail of the striatum (TS). Using a mouse model carrying a temporally controlled deletion of D2R within a subcircuit defined by WFS1 neurons, we found that intact EA D2R signaling is necessary to regulate homeostasis-dependent food-seeking behaviors in both male and female mice as well as active avoidance learning and innate escape responses in males. Altogether, these findings identify EA and TS D2R signaling as a novel hub through which dopamine optimizes appetitive behaviors and regulates the switch from passive to active defensive behaviors, regardless of learned or innate threats.

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“…center) or the elevated plus maze (i.e. open arms), does not require the EA-TS D2R signaling [34] but relies on the presence of D2R in striatopallidal neurons [97].…”

Section: Discussionmentioning

confidence: 99%

Dopamine D2 receptors in the extended amygdala scale the optimization of seeking and avoidance behaviors

Valjent

Castell²,

Gall³

et al. 2023

Preprint

Self Cite

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Optogenetic activation of striatal D1/D2 medium spiny neurons differentially engages downstream connected areas beyond the basal ganglia

Grimm

Frässle

Steger

et al. 2021

Preprint

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The basal ganglia (BG) are a group of subcortical nuclei responsible for motor control, motor learning and executive function. Central to BG function are striatal medium spiny neurons (MSNs) expressing D1 and D2 dopamine receptors. D1 and D2 MSNs are typically considered functional antagonists that facilitate voluntary movements and inhibit competing motor patterns, respectively. While their opposite role is well documented for certain sensorimotor loops of the BG-thalamocortical network, it is unclear whether MSNs maintain a uniform functional role across the striatum and which influence they exert on brain areas outside the BG. Here, we addressed these questions by combining optogenetic activation of D1 and D2 MSNs in the mouse ventrolateral caudoputamen (vl CPu) with whole-brain functional MRI (fMRI) recordings. Neuronal excitation of either cell population in the vl CPu evoked distinct activity patterns in key regions of the BG-thalamocortical network including the pallidum, thalamus and motor cortex. Importantly, we report that striatal D1 and D2 MSN stimulation differentially engaged cerebellar and prefrontal regions. We characterised these long-range interactions by computational modelling of effective connectivity and confirmed that changes in D1 / D2 output drive functional relationships between regions within and beyond the BG. These results suggest a more complex functional organization of MSNs across the striatum than previously anticipated and provide evidence for the existence of an interconnected fronto - BG - cerebellar network modulated by striatal D1 and D2 MSNs.

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Correction: Striatopallidal neurons control avoidance behavior in exploratory tasks

Cited by 2 publications

References 0 publications

Dopamine D2 receptors in the extended amygdala scale the optimization of seeking and avoidance behaviors

Dopamine D2 receptors in the extended amygdala scale the optimization of seeking and avoidance behaviors

Optogenetic activation of striatal D1/D2 medium spiny neurons differentially engages downstream connected areas beyond the basal ganglia

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