Correction: Single-Drug Therapy for Hypertension in Men

Materson, Barry J.; Reda, Domenic J.

doi:10.1056/nejm199406093302316

Cited by 43 publications

(30 citation statements)

References 1 publication

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“…18 This conclusion has been based on the observation that many elderly patients with essential hypertension have lower plasma renin activity and, therefore, may not respond to agents which block the renin-angiotensin system. However, the present study confirms other studies 16,19,20 which have shown that interruption of the renin-angiotensin system in combination with a diuretic is an effective treatment scheme for elderly patients with hypertension.…”

Section: Discussionsupporting

confidence: 92%

“…Calcium channel blockers such as nifedipine GITS have been previously shown to be effective in treating elderly hypertensives, [15][16][17] and this efficacy was confirmed in the present study. Based on these prior observations it has also been suggested that calcium channel blockers may be preferred anti-hypertensive agents for elderly hypertensives.…”

Section: Discussionsupporting

confidence: 84%

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A study of losartan, alone or with hydrochlorothiazide vs nifedipine GITS in elderly patients with diastolic hypertension

Conlin

Elkins²,

Liss

et al. 1998

J Hum Hypertens

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 84%

A study of losartan, alone or with hydrochlorothiazide vs nifedipine GITS in elderly patients with diastolic hypertension

Conlin

Elkins²,

Liss

et al. 1998

J Hum Hypertens

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“…1,2 Since most hypertensive patients are unlikely to reach the new BP targets with monotherapy, even at the highest dose of any antihypertensive drug, 3 the use of combinations of two agents has attracted increasing attention. Combining antihypertensive agents that lower BP by different mechanisms can allow better BP control providing additive antihypertensive effects while minimizing the likehood of dosedependent adverse effect.…”

Section: Introductionmentioning

confidence: 99%

Effect of benazepril addition to amlodipine on ankle oedema and subcutaneous tissue pressure in hypertensive patients

et al. 2003

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The aim of this study was to evaluate the effect of benazepril addition to amlodipine antihypertensive treatment on ankle-foot volume (AFV) and pretibial subcutaneous tissue pressure (PSTP), two objective measures of ankle oedema. A total of 32 mild to moderate essential hypertensives (DBP490 and o110 mmHg), aged 30-70 years were studied. After a 4-week placebo period, they were randomized to amlodipine 5 mg o.d. or benazepril 10 mg o.d. or amlodipine 5 mg plus benazepril 10 mg o.d. for 4 weeks, according to a crossover design. At the end of the placebo period and of each active treatment period, blood pressure,AFV and PSTP were evaluated. AFV was measured using the principle of water displacement. PSTP was assessed using a system, the subcutaneous pretibial interstitial enviroment with a water manometer. Both amlodipine and benazepril monotherapy significantly reduced SBP (À18.2 7 4 and À17.8 7 4 mmHg, respectively, Po0.01 vs baseline) and DBP (À12.1 7 3 and À11.7 7 3 mmHg, respectively, Po0.01); the reduction was increased by the combination (À24.2 7 5 mmHg for SBP, Po0.001 and À16.8 7 4 mmHg for DBP, Po0.001). Amlodipine monotherapy significantly increased both AFV (+17.1%, Po0.001 vs baseline) and PSTP (+56.6%, Po0.001 vs baseline). As compared to amlodipine alone, the combination produced a less pronounced increase in AFV (+5.5%, Po0.05 vs baseline and Po0.01 vs amlodipine) and PSTP (+20.5%, Po0.05 vs baseline and Po0.01 vs amlodipine). Ankle oedema was clinically evident in 11 patients with amlodipine monotherapy and in three patients with the combination. These results suggest that ACE-inhibitors partially counteract the microcirculatory changes responsible for Ca-antagonists-induced oedema formation.

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“…6 Our own early studies demonstrated that propranolol in titrated doses was equally effective to the then available potent antihypertensive drugs, the centrally acting methyldopa, and the adrenergic neurone inhibiting drugs bethanidine and guanethidine which thus lower the blood pressure by inhibiting vasoconstrictor impulses to alpha receptors. 3,10 Recent large clinical trials have demonstrated that beta-blockers, atenolol [11][12][13][14] or acebutolol 15 are similar in antihypertensive effect to examples from the major classes of hypotensive drugs. Similarly, in a large survey of veterans' hypertension clinic the achieved blood pressure with beta-blockers was similar to other agents, with or without a diuretic (Table 2).…”

Section: Beta 1 Selectivitymentioning

confidence: 99%

“…There was no reduction in the fall of blood pressure in those patients over 60 years compared to those below that age with bisoprolol alone or in combination. Materson et al [11][12][13] in their double-blind parallel group study of six different antihypertensive regimens did not find any age-related response to atenolol in white patients, 72% or those over 60 years old were successfully controlled compared to 65% below 60 years old. Jamerson and DeQuattro 26 reviewed 13 clinical trials in African Americans published between 1988 and 1993, and noted less fall of blood pressure with ACE inhibitors and beta-blockers compared to calcium channel blockers and diuretics.…”

Section: Effect Of Age and Race On The Antihypertensive Effect Of Betmentioning

confidence: 99%

New approaches to the uses of beta blocking drugs in hypertension

Prichard

Graham

Cruickshank³

2000

J Hum Hypertens

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After a slow start, beta-blockers have become widely used as first-line agents in the treatment of hypertension, and recommended as such in recently published guidelines. There is evidence that the beta 1 -selective agents are more efficacious than non-selective blockers that inhibit both beta 1 and beta 2 receptors. Notwithstanding some earlier evidence to the contrary, it appears that beta 1 -selective drugs are equi-effective in young and elderly whites, younger, ie, under mid 60s, blacks. It is with the combination of age and being black that beta-blockers are usually less useful than some other groups of antihypertensive drugs, most notably calcium antagonists and diuretics. Primary prevention studies indicate beta-blockers reduce the incidence of cerebro-vascular disease and coronary heart disease in younger patients but they appear less effective than diuretics in the elderly. Beta-blockers are particularly indicated in patients who have experienced a myocar-

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Correction: Single-Drug Therapy for Hypertension in Men

Cited by 43 publications

References 1 publication

A study of losartan, alone or with hydrochlorothiazide vs nifedipine GITS in elderly patients with diastolic hypertension

A study of losartan, alone or with hydrochlorothiazide vs nifedipine GITS in elderly patients with diastolic hypertension

Effect of benazepril addition to amlodipine on ankle oedema and subcutaneous tissue pressure in hypertensive patients

New approaches to the uses of beta blocking drugs in hypertension

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