Correction: Self-Regulation of Anterior Insula with Real-Time fMRI and Its Behavioral Effects in Obsessive-Compulsive Disorder: A Feasibility Study

Buyukturkoglu, Korhan; Roettgers, Hans; Sommer, Jens; Rana, Mohit; Dietzsch, Leonie; Arikan, Ezgi Belkis; Veit, Ralf; Malekshahi, Rahim; Kircher, Tilo; Birbaumer, Niels; Sitaram, Ranganatha; Ruíz, Sergio

doi:10.1371/journal.pone.0145027

Cited by 3 publications

(2 citation statements)

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“…It is still unclear how learning and the real-time view of the activation of specific brain areas in their own brain may allow individuals to modify responses of these areas. These techniques, albeit still relatively limited, have already been applied to studies on sleep and sleep deprivation (Muto et al, 2012 ; Mascetti et al, 2013 ), chronic pain (Guan et al, 2015 ), control of adverse stimuli (Paret et al, 2015 ), obsessive-compulsive disorder (Buyukturkoglu et al, 2015 ), depression (Linden et al, 2012 ) and schizophrenia (Ruiz et al, 2013 ). For an extensive list, see Table 1 in Brühl ( 2015 ).…”

Section: Future Developmentsmentioning

confidence: 99%

The Brain from Within

Porzio

2016

Front. Hum. Neurosci.

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Functional magnetic resonance imaging (fMRI) provides a powerful way to visualize brain functions and observe brain activity in response to tasks or thoughts. It allows displaying brain damages that can be quantified and linked to neurobehavioral deficits. fMRI can potentially draw a new cartography of brain functional areas, allow us to understand aspects of brain function evolution or even breach the wall into cognition and consciousness. However, fMRI is not deprived of pitfalls, such as limitation in spatial resolution, poor reproducibility, different time scales of fMRI measurements and neuron action potentials, low statistical values. Thus, caution is needed in the assessment of fMRI results and conclusions. Additional diagnostic techniques based on MRI such as arterial spin labeling (ASL) and the measurement of diffusion tensor imaging (DTI) provide new tools to assess normal brain development or disruption of anatomical networks in diseases. A cutting edge of recent research uses fMRI techniques to establish a “map” of neural connections in the brain, or “connectome”. It will help to develop a map of neural connections and thus understand the operation of the network. New applications combining fMRI and real time visualization of one’s own brain activity (rtfMRI) could empower individuals to modify brain response and thus could enable researchers or institutions to intervene in the modification of an individual behavior. The latter in particular, as well as the concern about the confidentiality and storage of sensitive information or fMRI and lie detectors forensic use, raises new ethical questions.

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Section: Future Developmentsmentioning

confidence: 99%

The Brain from Within

Porzio

2016

Front. Hum. Neurosci.

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“…)。而神经重用观点则假设, 加工各种情绪信息刺激(如情绪面孔、情绪图片等)的大脑区域 , 可能也负责词汇的情绪信息加工 (Anderson, 2007;Anderson, 2010;Dehaene & Cohen, 2007 et al, 2008); 语义 N400 成分, 也受情绪的影响 (Herbert et al, 2008;Kanske & Kotz, 2007); 还有后部晚正成分(the late posterior positivity, LPP), 它可能反映了更深层次的信息整合过程 (Bayer et al, 2010;Fischler & Bradley, 2006;Kanske & Kotz, 2007;Schacht & Sommer, 2009a, 2009b)。最早探索 (Herbert et al, 2008;Kissler et al, 2007;Schacht & Sommer, 2009a, 2009bSchupp et al, 2004), 它被认为是对情绪词视觉注意初始分配的反映 (Herbert et al, 2008) Kissler et al, 2007;Ponz et al, 2013) (Liu et al, 2015;Schienle et al, 2016;Watkins et al, 2015)、脑损伤 (Borg et al, 2013, Buyukturkoglu et al, 2015,…”

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Evidence for neural re-use hypothesis from the processing of Chinese emotional words

Sun¹,

Hao²,

He³

et al. 2021

Acta Psychol Sin

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The Clinical Impact of Real-Time fMRI Neurofeedback on Emotion Regulation: A Systematic Review

Tschentscher,

Tafelmaier,

Woll

et al. 2024

Brain Sciences

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Emotion dysregulation has long been considered a key symptom in multiple psychiatric disorders. Difficulties in emotion regulation have been associated with neural dysregulation in fronto-limbic circuits. Real-time fMRI-based neurofeedback (rt-fMRI-NFB) has become increasingly popular as a potential treatment for emotional dysregulation in psychiatric disorders, as it is able to directly target the impaired neural circuits. However, the clinical impact of these rt-fMRI-NFB protocols in psychiatric populations is still largely unknown. Here we provide a comprehensive overview of primary studies from 2010 to 2023 that used rt-fMRI-NFB to target emotion regulation. We assessed 41 out of 4001 original studies for methodological quality and risk of bias and synthesised concerning the frequency of significant rt-fMRI-NFB-related effects on the neural and behaviour level. Successful modulation of brain activity was reported in between 25 and 50 percent of study samples, while neural effects in clinical samples were more diverse than in healthy samples. Interestingly, the frequency of rt-fMRI-NFB-related behavioural improvement was over 75 percent in clinical samples, while healthy samples showed behavioural improvements between 0 and 25 percent. Concerning clinical subsamples, rt-fMRI-NFB-related behavioural improvement was observed in up to 100 percent of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) samples. Substance use samples showed behavioural benefits ranging between 50 and 75 percent. Neural effects appeared to be less frequent than behavioural improvements: most neural outcomes ranged between 25 and 50 percent for MDD and substance use and between 0 and 25 percent for PTSD. Using multiple individualised regions of interest (ROIs) for rt-fMRI-NFB training resulted in more frequent behavioural benefits than rt-fMRI-NFB solely based on the amygdala or the prefrontal cortex. While a significant improvement in behavioural outcomes was reported in most clinical studies, the study protocols were heterogeneous, which limits the current evaluation of rt-fMRI-NFB as a putative treatment for emotional dysregulation.

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Correction: Self-Regulation of Anterior Insula with Real-Time fMRI and Its Behavioral Effects in Obsessive-Compulsive Disorder: A Feasibility Study

Cited by 3 publications

References 1 publication

The Brain from Within

The Brain from Within

Evidence for neural re-use hypothesis from the processing of Chinese emotional words

The Clinical Impact of Real-Time fMRI Neurofeedback on Emotion Regulation: A Systematic Review

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