Correction: Radiotherapy resistance acquisition in Glioblastoma. Role of SOCS1 and SOCS3

Ventero, María Paz; Fuentes-Baile, María; Quereda, Cristina; Perez-Valeciano, Elizabeth; Alenda, Cristina; García-Morales, Pilar; Esposito, Danilo; Dorado, Pilar; Barberá, Víctor Manuel; Sacedan, Miguel

doi:10.1371/journal.pone.0215714

Cited by 5 publications

(4 citation statements)

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“…Previous studies demonstrated that SOCS1 was low expression in many types of cancer, such as anaplastic thyroid cancer [38], gastric cancer [39], hypopharyngeal carcinoma [40], and breast cancer [41]. however, several studies have also shown that SOCS1 expression level was increased in colorectal cancer [42], glioblastoma [43], and triple-negative breast cancer [44]. Several studies indicated SOCS-1 was downregulated in lung cancer and exerted an antitumor effect by suppressing the JAK/STAT [21,45].…”

Section: Discussionmentioning

confidence: 99%

Expression Status and Prognostic Values of SOCS Family Genes in Non-small Cell Lung Cancer

Zhang¹,

Sun²,

Bao³

2021

Preprint

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Backgroud:Suppressors of cytokine signaling (SOCS) family play important roles in the development of cancers by inhibiting the transmission of the Janus kinases–signal transducers and activators of transcription (JAK-STAT) signaling pathway. However, the expression patterns and prognostic value of SOCS family genes in non-small cell lung cancer (NSCLC) remains unclear. Methods: The SOCS family genes expression profiles were explored using ONCOMINE and GEPIA online tools. The mutation and copy number alterations of SOCS family genes in NSCLC were assessed by cBioportal for Cancer Genomics. The methylation status of SOCS family members were analyzed through MEXPRESS and UCSC Xena website. The prognostic values of SOCS family genes in NSCLC were explored through Kaplan-Meier Plotter database. Results: The expression levels of SOCS2, SOCS3, and cytokine-inducible SH2-containing protein (CIS/CISH) were significantly reduced in NSCLC tissues compared to normal lung tissues. The aberrant DNA methylation of SOCS family genes were frequent in NSCLC. CISH methylation was negatively correlated with gene expression in NSCLC. The Kaplan-Meier Plotter analysis demonstrated high expression of SOCS1 may be a predictor of poor prognosis in lung adenocarcinoma(LUAD) but served as a favorable prognostic marker of lung squamous cell carcinoma. The high expression levels of SOCS2 and SOCS4-7 were significantly correlated with better overall survival (OS) in LUAD but not in lung squamous carcinoma (LUSC) patients. Conclusions:Our findings indicated that the aberrant gene expression and DNA methylation of SOCS family members are common in NSCLC and contribute to tumorigenesis. SOCS family genes may serve as therapeutic targets and prognostic biomarkers for NSCLC patients

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Section: Discussionmentioning

confidence: 99%

Expression Status and Prognostic Values of SOCS Family Genes in Non-small Cell Lung Cancer

Zhang¹,

Sun²,

Bao³

2021

Preprint

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“…Therefore, E3 ubiquitin ligase β-TrCP serves an important role in regulating PHLPP1, which provides a novel and alternative focus for the study of GBM ( 76 ). Furthermore, PHLPP1 inhibits STAT1 phosphorylation and, therefore, its transcriptional activity in the nucleus, uncovering a potential mechanism for SOCS protein synergistic inhibition of STAT phosphorylation as a way to regulate GBM development ( 77 ).…”

Section: Socs Proteins and E3 Ubiquitin Ligasementioning

confidence: 99%

“…Furthermore, SOCS may serve as novel therapeutic targets to improve the radiotherapy response of GBM through the JAK/STAK signaling pathway. Ventero et al ( 77 ) reduced SOCS1 and SOCS3 expression via small interfering RNAs and reported that inhibition of SOCS3 increased the radiation resistance of GBM cell lines, whereas silencing of SOCS1 had no effect. It was predicted that this result was related to the JAK/STAK signaling pathway, but further work is needed to verify this hypothesis.…”

Section: Socs Proteins and Signal Transductionmentioning

confidence: 99%

SOCS proteins and their roles in the development of glioblastoma (Review)

Dai

Liang³

et al. 2021

Oncol Lett

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“…However, these therapies are limited by maximal dose, radiation-induced toxicity, and risk of complications [ 136 ] . Additionally, GBMs can develop resistance to radiation therapies due to activation and adaptation of DNA repair pathways [ 42 , 148 ] .…”

Section: Current Status Of Therapymentioning

confidence: 99%

The role of extracellular vesicles in acquisition of resistance to therapy in glioblastomas

Yekula¹,

Taylor²,

Beecroft³

et al. 2020

CDR

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Glioblastoma (GBM) is the most aggressive primary brain tumor with a median survival of 15 months despite standard care therapy consisting of maximal surgical debulking, followed by radiation therapy with concurrent and adjuvant temozolomide treatment. The natural history of GBM is characterized by inevitable recurrence with patients dying from increasingly resistant tumor regrowth after therapy. Several mechanisms including inter- and intratumoral heterogeneity, the evolution of therapy-resistant clonal subpopulations, reacquisition of stemness in glioblastoma stem cells, multiple drug efflux mechanisms, the tumor-promoting microenvironment, metabolic adaptations, and enhanced repair of drug-induced DNA damage have been implicated in therapy failure. Extracellular vesicles (EVs) have emerged as crucial mediators in the maintenance and establishment of GBM. Multiple seminal studies have uncovered the multi-dynamic role of EVs in the acquisition of drug resistance. Mechanisms include EV-mediated cargo transfer and EVs functioning as drug efflux channels and decoys for antibody-based therapies. In this review, we discuss the various mechanisms of therapy resistance in GBM, highlighting the emerging role of EV-orchestrated drug resistance. Understanding the landscape of GBM resistance is critical in devising novel therapeutic approaches to fight this deadly disease.

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Correction: Radiotherapy resistance acquisition in Glioblastoma. Role of SOCS1 and SOCS3

Cited by 5 publications

References 1 publication

Expression Status and Prognostic Values of SOCS Family Genes in Non-small Cell Lung Cancer

Expression Status and Prognostic Values of SOCS Family Genes in Non-small Cell Lung Cancer

SOCS proteins and their roles in the development of glioblastoma (Review)

The role of extracellular vesicles in acquisition of resistance to therapy in glioblastomas

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