Correction: Punica granatum (pomegranate) peel extract exerts potent antitumor and anti-metastasis activity in thyroid cancer

Li, Yujue; Ye, Tinghong; Yang, Fangfang; Hu, Mingxing; Liu, Liang; He, He; Li, Zhipeng; Zeng, Anqi; Li, Yali; Yao, Yuqin; Xie, Yongmei; An, Zhenmei; Li, Shuangqing

doi:10.1039/c7ra90068f

Cited by 2 publications

(2 citation statements)

References 51 publications

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“…A combination of its polyphenol extract with gallic acid exhibited both in vitro and in vivo antifungal properties against Candida strains, Trichophyton rubrum via inhibition of sterol 14 α-demethylase P450 (CYP51) and squalene epoxidase in the T. rubrum membrane. (Li, Ye, et al, 2017;Li, Liu, et al, 2017). While its combination with the azole fungicide prochloraz demonstrated synergistic growth inhibition of the mycotoxigenic fungi (Aspergillus flavus and Fusarium proliferatum) and their toxins production, reducing the effective dose of azole drugs, and subsequently with less side effects (Sadhasivam et al, 2019).…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…Anti-tumor action mechanisms of PPE and its constituents is exerted via multiple targets, that is, antioxidant (Waly et al, 2014), antiangiogenic (Ceci et al, 2018;Naseri et al, 2018), anti-proliferative (Dikmen et al, 2011;Fazio et al, 2018;Li, Ye, et al, 2017;Li, Liu, et al, 2017), anti-metastatic (Deng et al, 2017;, and apoptosis induction (Chang et al, 2018;Li et al, 2019). Furthermore, it inhibited several oncogenic signaling pathways, for example, NF-κB, PI3K/AKT/Mtor (Khwairakpam et al, 2018), oncogenes expression responsible for cancer development (e.g., anti-apoptotic genes (Dikmen et al, 2011), and MMPs (Deng et al, 2017;Khwairakpam et al, 2018;Li, Ye, et al, 2017;Li, Liu, et al, 2017), concurrent with the induction of pro-apoptotic protein caspase-3 activity Deng et al, 2017;Li et al, 2014), BCL-2-associated X protein/B-cell lymphoma 2 (Bax/Bcl-2) ratio (Deng et al, 2017;Dikmen et al, 2011;Li et al, 2014) and the apoptosis-associated protein, P53, expression (Song et al, 2016).…”

Section: Anticancer Activitymentioning

confidence: 99%

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Ongoing and potential novel trends of pomegranate fruit peel; a comprehensive review of its health benefits and future perspectives as nutraceutical

Fahmy

Farag

2021

Journal of Food Biochemistry

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Pomegranate is an ancient shrub, globally distributed nowadays. It has been used in the middle east as a medicinal food and traditional medicine for thousands of years.Pomegranate peel (PP) constitutes about 50% of the total fruit, however, it has been previously regarded as a waste. Recent research points to PP as a rich source of phenolics (e.g., ellagitannins, flavonoids, and anthocyanins), polysaccharides, in addition to its biotransformed metabolites viz. urolithins making it a valuable waste with promising pharmacological actions.Compared to the pulp and the juice, PP exhibited stronger antioxidant and antimicrobial activities. Besides, it inhibited inflammation in several conditions, including colitis, arthritis, hepatitis, contact dermatitis, and lung inflammation. Moreover, it displayed anti-osteoporosis, anti-hyperglycemic, antidiabetic, antihypertensive, vasculoprotective, hepatoprotective, neuroprotective, and immunomodulatory effects. Additionally, it was effective as a prebiotic and in obesity control, besides it promoted wound healing. Furthermore, PP demonstrated anticancer effects against different cancer types, for example, colon, liver, thyroid, uterine, breast, bladder, prostate, leukemia, and osteosarcoma. Despite PP safety, it may interfere with the metabolism of other drugs because it inhibits cytochromes (CYP) changing their bioavailability, effectiveness, and toxicity. PP biowaste valorization not only avoids against its environmental and economic burden but can also provide a promising platform to produce novel or improved nutraceuticals. This study provides a comprehensive overview of PP biological activities with the reported action mechanisms related to its phytochemicals and further biotransformed metabolites inside the body. Future research prospects to unravel the merits of such waste and optimize its use are discussed.Practical application: Pomegranate is widely distributed throughout the world.Although its peel was previously considered a waste, recent research regards it as a rich source of bioactive compounds with promising biological activities. Its recycling not only overcomes the bio-waste problems, but also provides a source of valuable compounds with several health benefits.

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Section: Antimicrobial Activitymentioning

confidence: 99%

Section: Anticancer Activitymentioning

confidence: 99%

Ongoing and potential novel trends of pomegranate fruit peel; a comprehensive review of its health benefits and future perspectives as nutraceutical

Fahmy

Farag

2021

Journal of Food Biochemistry

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An Insight into Anticancer Bioactives from Punica granatum (Pomegranate)

Sharma¹,

Kesharwani²,

Prajapati³

et al. 2022

ACAMC

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: Cancer is one of the major reasons for mortality across the globe. Side effects that are observed with the pharmacological medications present in the market majorly affect the quality of life of patients. This has caused the researchers to find an alternative source of medications such as herbal medicine which has shown a promising effect in anticancer treatment, one such source is Pomegranate, which belongs to the family Punicaceae. Several polyphenols are present in Punica granatum which exhibits properties ranging from antioxidant effect, antidiabetic effect, beneficial impact in treatment, and management of metabolic and cardiovascular disorders to advantageous impact in anticancer treatment. Polyphenols like punicalin, punicalagin, and ellagic acid are a few of the many compounds responsible for the anticancer activity of pomegranate. Many preparations of pomegranate such as Pomegranate Juice (PJ), Pomegranate seed oil (PSO), Pomegranate peel extract (PoPx) etc. are used in various clinical studies. These polyphenols show anticancer activity by either arresting the cell cycle in the G2/M phase, inducing apoptosis, or by damaging the DNA of tumor cells. This review explicitly discusses the role and mechanism of bioactives obtained from the pomegranate in the treatment and management of cancer. The chemical structure, properties and role of pomegranate in the treatment of breast, lung, thyroid, colon, and prostate cancer has been focused in detail. This review also discusses various drug delivery approaches for targeted delivery on tumors as well as patented preparation of pomegranate compounds along with the ongoing clinical trials.

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Correction: Punica granatum (pomegranate) peel extract exerts potent antitumor and anti-metastasis activity in thyroid cancer

Abstract: Correction for ‘Punica granatum (pomegranate) peel extract exerts potent antitumor and anti-metastasis activity in thyroid cancer’ by Yujue Li et al., RSC Adv., 2016, 6, 84523–84535.

Cited by 2 publications

References 51 publications

Ongoing and potential novel trends of pomegranate fruit peel; a comprehensive review of its health benefits and future perspectives as nutraceutical

Ongoing and potential novel trends of pomegranate fruit peel; a comprehensive review of its health benefits and future perspectives as nutraceutical

An Insight into Anticancer Bioactives from Punica granatum (Pomegranate)

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