Correction: Protease Nexin I is a feedback regulator of EGF/ PKC/MAPK/EGR1 signaling in breast cancer cells metastasis and stemness

Tang, Tingting; Zhu, Qinhua; Li, Xinping; Zhu, Gaole; Deng, Siwei; Wang, Yingshan; Ni, Lingyu; Chen, Xinyuan; Zhang, Yanfeng; Xia, Tiansong; Zen, Ke; Pan, Yi; Liang, Jin

doi:10.1038/s41419-019-2211-z

“…Both EGF and its receptor partake in the pathogenesis of multiple carcinomas, thus constituting attractive targets for molecular therapy. Previous studies have demonstrated that EGF and EGFR are implicated in the invasion and migration of thyroid tumors, and that PN-1 can form a positive feedback with EGF/EGFR signaling to promote the biological activity of breast cancer cells (11)(12)(13). Therefore, the present study aimed to explore whether SERPINE2 could form positive feedback signals with EGF/EGFR, and participate in the proliferation, invasion and migration of papillary thyroid carcinoma.…”

Section: Introductionmentioning

confidence: 95%

SERPINE2 feedback regulates EGF/EGFR signaling in human papillary thyroid carcinoma cells

Chu

¹

,

Hu

²

,

Su

³

2021

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Fluorescence Lifetime Imaging of Lipid Heterogeneity in the Inner Mitochondrial Membrane with a Super‐photostable Environment‐Sensitive Probe

Wang,

Taki,

Ohba

et al. 2024

Angewandte Chemie

0

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The inner mitochondrial membrane (IMM) undergoes dynamic morphological changes, which are crucial for the maintenance of mitochondrial functions as well as cell survival. As the dynamics of the membrane are governed by its lipid components, a fluorescent probe that can sense spatiotemporal alterations in the lipid properties of the IMM over long periods of time is required to understand mitochondrial physiological functions in detail. Herein, we report a red‐emissive IMM‐labeling reagent with excellent photostability and sensitivity to its environment, which enables the visualization of the IMM ultrastructure using super‐resolution microscopy as well as of the lipid heterogeneity based on the fluorescence lifetime at the single mitochondrion level. Combining the probe and fluorescence lifetime imaging microscopy (FLIM) showed that peroxidation of unsaturated lipids in the IMM by reactive oxygen species caused an increase in the membrane order, which took place prior to mitochondrial swelling.

show abstract

Fluorescence Lifetime Imaging of Lipid Heterogeneity in the Inner Mitochondrial Membrane with a Super‐photostable Environment‐Sensitive Probe

Wang,

Taki,

Ohba

et al. 2024

Angew Chem Int Ed

2

0

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The inner mitochondrial membrane (IMM) undergoes dynamic morphological changes, which are crucial for the maintenance of mitochondrial functions as well as cell survival. As the dynamics of the membrane are governed by its lipid components, a fluorescent probe that can sense spatiotemporal alterations in the lipid properties of the IMM over long periods of time is required to understand mitochondrial physiological functions in detail. Herein, we report a red‐emissive IMM‐labeling reagent with excellent photostability and sensitivity to its environment, which enables the visualization of the IMM ultrastructure using super‐resolution microscopy as well as of the lipid heterogeneity based on the fluorescence lifetime at the single mitochondrion level. Combining the probe and fluorescence lifetime imaging microscopy (FLIM) showed that peroxidation of unsaturated lipids in the IMM by reactive oxygen species caused an increase in the membrane order, which took place prior to mitochondrial swelling.

show abstract

Correction: Protease Nexin I is a feedback regulator of EGF/ PKC/MAPK/EGR1 signaling in breast cancer cells metastasis and stemness

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cited by 4 publications

References 0 publications

SERPINE2 feedback regulates EGF/EGFR signaling in human papillary thyroid carcinoma cells

SERPINE2 feedback regulates EGF/EGFR signaling in human papillary thyroid carcinoma cells

Fluorescence Lifetime Imaging of Lipid Heterogeneity in the Inner Mitochondrial Membrane with a Super‐photostable Environment‐Sensitive Probe

Fluorescence Lifetime Imaging of Lipid Heterogeneity in the Inner Mitochondrial Membrane with a Super‐photostable Environment‐Sensitive Probe

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