Correction: Positional Cloning Reveals Strain-Dependent Expression of Trim16 to Alter Susceptibility to Bleomycin-Induced Pulmonary Fibrosis in Mice

Stefanov, Anguel N.; Fox, Jessica L.; Depault, François; Haston, Christina K.

doi:10.1371/annotation/f184e509-5c53-48da-b94a-b7517f591b3e

Cited by 5 publications

(2 citation statements)

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“…Previous studies reported that C57BL/6J mice are highly susceptible to lung injury following intratracheal BLM administration. Therefore, this strain may be an alternative model for investigating BLM-induced pulmonary fibrosis (43,44). Another limitation was that the number of studies included was small and certain studies may have publication bias.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of bone marrow mesenchymal stem cell transplantation in animal models of pulmonary fibrosis after exposure to bleomycin: A meta‑analysis

et al. 2019

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Previous studies have demonstrated that bone marrow mesenchymal stem cell (BMSC) transplantation is a promising treatment strategy for pulmonary fibrosis. Although encouraging results have been obtained using animal models of bleomycin (BLM)-induced pulmonary fibrosis, it is evident that transplantation of BMSCs at various time-points after BLM administration has produced different results in terms of treatment efficacy. To shed light on the potential utility of BMSCs for the treatment of lung disease, the present study performed a meta-analysis to estimate the efficacy of BMSCs in animal models of BLM-induced pulmonary fibrosis, and compare early transplantation (BMSCs injected on the same day after administration of BLM) with late transplantation (BMSCs injected on the 14th day after administration of BLM). Relevant studies were retrieved from the MEDLINE, PubMed, Chinese Knowledge Infrastructure and WanFang databases using a comprehensive search approach. A total of 6 studies involving 228 model rats were included. Meta-analysis indicated that early BMSC transplantation was able to prevent or reduce BLM-induced alveolitis and pulmonary fibrosis, while late BMSC transplantation was able to reduce alveolitis, but there was no significant evidence regarding improvement of pulmonary fibrosis. Although BMSC therapy was identified to be generally beneficial in rodent models of BLM-induced pulmonary fibrosis, the efficacy of early transplantation appears to be more satisfactory; overall, the efficacy of transplantation of BMSCs at the acute inflammatory phase was more effective compared with that at the chronic fibrosis stage. Of note, regarding alveolitis and pulmonary fibrosis scores after late transplantation of BMSCs, the sensitivity analysis revealed that the scores were less stable; thus, this result must be interpreted with caution. Furthermore, the quality and methodology of the included studies was comparatively low. Therefore, higher-quality and more rigorous studies are required to validate the results of the present meta-analysis in the future.

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Section: Discussionmentioning

confidence: 99%

Efficacy of bone marrow mesenchymal stem cell transplantation in animal models of pulmonary fibrosis after exposure to bleomycin: A meta‑analysis

et al. 2019

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“…Significant downregulation of miR‐30a‐3p has been reported in patients with diabetic nephropathy compared with normal controls 14 . Tripartite motif‐containing protein 16 (TRIM16) was found to aggravate murine lung fibrosis and was highly expressed in mice with diabetes 15,16 . Moreover, TRIM16 is the target gene of miR‐30a‐3p.…”

Section: Introductionmentioning

confidence: 99%

Cordyceps cicadae polysaccharides attenuate diabetic nephropathy via the miR‐30a‐3p/TRIM16 axis

Zheng,

Xu,

Wang

et al. 2023

J of Diabetes Invest

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ObjectiveThe molecular mechanism of the protective effect of Cordyceps cicadae polysaccharides (CCPs) on renal tubulointerstitial fibrosis in diabetic nephropathy (DN) is still unclear. This study aims to further understand the molecular mechanisms behind the therapeutic benefits of CCP on diabetic nephropathy.MethodsMice were randomly assigned into six groups (n = 8). Cordyceps cicadae polysaccharide dissolved in 5% dimethyl sulfoxide was administered by gavage for 12 consecutive weeks. The CCP doses were divided into low, medium, and high, 75, 150, and 300 mg/kg/day, respectively. The efficacy of CCP was determined by assessing the renal function and histological alterations in diabetic db/db mice. The degree of glomerular mesangial dilatation and sclerosis was evaluated using semiquantitative markers. Cell viability, apoptosis, epithelial–mesenchymal transition (EMT), inflammation, oxidative stress, and mitochondrial reactive oxygen species (ROS) in high glucose (HG)‐cultured MPC5 podocytes were determined. The interaction of miR‐30a‐3p and tripartite motif‐containing protein 16 (TRIM16) was examined by luciferase reporter assay. Western blotting, reverse transcription‐polymerase chain reaction, and immunofluorescence were used to analyze gene and protein expressions.ResultsThe in vivo findings illustrated that CCP may protect mice with type 2 diabetes from inflammation and oxidative damage (P < 0.05). Furthermore, CCP has a therapeutic value in protecting renal function and morphology in diabetic nephropathy by reversing podocyte EMT. The in vitro results indicated that CCP dose‐dependently inhibited HG‐induced apoptosis, EMT, inflammation, oxidative stress, and mitochondrial ROS levels in MPC5 podocytes (P < 0.05). Luciferase reporter assay confirmed the interaction between miR‐30a‐3p and TRIM16 in MPC5 podocytes cultured in high glucose (P < 0.05).ConclusionThe protective effect of CCP on HG‐induced MPC5 can be achieved by miR‐30a‐3p/TRIM16 axis.

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Genetic Factors Involved in Susceptibility to Lung Disease

et al. 2014

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Correction: Positional Cloning Reveals Strain-Dependent Expression of Trim16 to Alter Susceptibility to Bleomycin-Induced Pulmonary Fibrosis in Mice

Cited by 5 publications

References 0 publications

Efficacy of bone marrow mesenchymal stem cell transplantation in animal models of pulmonary fibrosis after exposure to bleomycin: A meta‑analysis

Efficacy of bone marrow mesenchymal stem cell transplantation in animal models of pulmonary fibrosis after exposure to bleomycin: A meta‑analysis

Cordyceps cicadae polysaccharides attenuate diabetic nephropathy via the miR‐30a‐3p/TRIM16 axis

Genetic Factors Involved in Susceptibility to Lung Disease

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