Correction: Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells

Mansouri, Rafik; Jouan, Y.; Haÿ, Eric; Blin-Wakkach, Claudine; Frain, Monique; Ostertag, Agnès; Hénaff, Carole Le; Marty, Caroline; Geoffroy, Valérie; Marie, Pierre J.; Cohen‐Solal, Martine; Modrowski, Dominique

doi:10.1038/s41419-018-0830-4

Cited by 3 publications

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“…In addition to regulating cartilage maturation, PGs have been identified as modulators of osteoblast differentiation [ 116 ]. It was shown that CS chains enhance osteoblast differentiation by binding to both cadherin-1 and n -cadherin, decreasing extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation, activating Smad 3 and Smad 1/5/8 signalling pathways, and increasing the expression of osteoblastic differentiation markers, such as ALP [ 117 ].…”

Section: Pgs’ Function In Cell-ecm Crosstalk and Skeletal Developmentmentioning

confidence: 99%

Two Modulators of Skeletal Development: BMPs and Proteoglycans

Koosha

Eames

2022

JDB

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During embryogenesis, skeletal development is tightly regulated by locally secreted growth factors that interact with proteoglycans (PGs) in the extracellular matrix (ECM). Bone morphogenetic proteins (BMPs) are multifunctional growth factors that play critical roles in cartilage maturation and bone formation. BMP signals are transduced from plasma membrane receptors to the nucleus through both canonical Smad and noncanonical p38 mitogen-activated protein kinase (MAPK) pathways. BMP signalling is modulated by a variety of endogenous and exogenous molecular mechanisms at different spatiotemporal levels and in both positive and negative manners. As an endogenous example, BMPs undergo extracellular regulation by PGs, which generally regulate the efficiency of ligand-receptor binding. BMP signalling can also be exogenously perturbed by a group of small molecule antagonists, such as dorsomorphin and its derivatives, that selectively bind to and inhibit the intracellular kinase domain of BMP type I receptors. In this review, we present a current understanding of BMPs and PGs functions in cartilage maturation and osteoblast differentiation, highlighting BMP–PG interactions. We also discuss the identification of highly selective small-molecule BMP receptor type I inhibitors. This review aims to shed light on the importance of BMP signalling and PGs in cartilage maturation and bone formation.

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Section: Pgs’ Function In Cell-ecm Crosstalk and Skeletal Developmentmentioning

confidence: 99%

Two Modulators of Skeletal Development: BMPs and Proteoglycans

Koosha

Eames

2022

JDB

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Heparan sulfate proteoglycans: The sweet side of development turns sour in mucopolysaccharidoses

Pasquale

Pavone

2019

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Extracellular matrix-induced signaling pathways in mesenchymal stem/stromal cells

Novoseletskaya,

Evdokimov,

Efimenko

2023

Cell Commun Signal

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The extracellular matrix (ECM) is a crucial component of the stem cell microenvironment, or stem-cell niches, and contributes to the regulation of cell behavior and fate. Accumulating evidence indicates that different types of stem cells possess a large variety of molecules responsible for interactions with the ECM, mediating specific epigenetic rearrangements and corresponding changes in transcriptome profile. Signals from the ECM are crucial at all stages of ontogenesis, including embryonic and postnatal development, as well as tissue renewal and repair. The ECM could regulate stem cell transition from a quiescent state to readiness to perceive the signals of differentiation induction (competence) and the transition between different stages of differentiation (commitment). Currently, to unveil the complex networks of cellular signaling from the ECM, multiple approaches including screening methods, the analysis of the cell matrixome, and the creation of predictive networks of protein–protein interactions based on experimental data are used. In this review, we consider the existing evidence regarded the contribution of ECM-induced intracellular signaling pathways into the regulation of stem cell differentiation focusing on mesenchymal stem/stromal cells (MSCs) as well-studied type of postnatal stem cells totally depended on signals from ECM. Furthermore, we propose a system biology-based approach for the prediction of ECM-mediated signal transduction pathways in target cells.

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Correction: Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells

Abstract: The PDF and HTML versions of the article have been updated to include the Creative Commons Attribution 4.0 International License information.

Cited by 3 publications

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Two Modulators of Skeletal Development: BMPs and Proteoglycans

Two Modulators of Skeletal Development: BMPs and Proteoglycans

Heparan sulfate proteoglycans: The sweet side of development turns sour in mucopolysaccharidoses

Extracellular matrix-induced signaling pathways in mesenchymal stem/stromal cells

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