Correction of the anemia of epidermolysis bullosa with intravenous iron and erythropoietin

Fridge, Jacqueline; Vichinsky, Elliott

doi:10.1016/s0022-3476(98)70321-x

Cited by 31 publications

(25 citation statements)

References 6 publications

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“…This therapy has been used for premature newborns in combination with erythropoietin, in epidermolysis bullosa and for children receiving total parenteral nutrition [3, 11]. Very few studies have been conducted in children with iron deficiency anemia treated with parenteral and especially intravenous iron therapy [1, 5, 9].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Iron Deficiency Anemia with Intravenous Iron Preparations

Akarsu

Taşkın²,

Yı́lmaz³

et al. 2006

Acta Haematol

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Objective: We aimed to determine the effects of intravenous iron therapy on blood parameters in pediatric patients who do not tolerate oral iron therapy for any reason. Patients and Methods: The patient group consisted of candidates for elective operations requiring blood transfusions in order to raise hemoglobin (Hb) concentrations rapidly and for whom oral iron administration is useless and compliance with long-term treatment is definitely impossible due to sociocultural factors. Sixty-two children were included in the study. Venous blood samples were taken at diagnosis, and after 1 week and 1, 2 and 3 months. Hb, hematocrit, erythrocyte indices (mean erythrocyte volume, mean erythrocyte Hb and mean erythrocyte Hb concentration), serum iron (SI) levels, iron binding capacity, transferrin receptor (CD71) and serum ferritin levels were measured. Iron sucrose was used as an intravenous iron preparation. Results: All children showed improvements in iron deficiency anemia. A statistically significant elevation occurred between the time of diagnosis and week 1 (p<0.05) in nearly all parameters. SI was raised until at least 1 month of therapy. There was no significant difference between transferrin receptors measured before and after the intravenous iron therapy. Ferritin did not exceed the values achieved in the 1st month. Mild side effects were encountered in only 8 (12.9%) patients. Treatment was not discontinued because of side effects in any case. The patients in the control group were given an oral form containing ferroglycine sulfate. Conclusion: Intravenous iron therapy can replace oral therapy in patients whose blood parameters must be raised rapidly and in situations where oral iron administration would not be appropriate for any reason. However, reinforcement with oral iron therapy or additional intravenous doses would be appropriate.

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Section: Discussionmentioning

confidence: 99%

Treatment of Iron Deficiency Anemia with Intravenous Iron Preparations

Akarsu

Taşkın²,

Yı́lmaz³

et al. 2006

Acta Haematol

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“…64 There is also some evidence for the reduced absorption of iron from the gut in EB, thereby also limiting the potential benefits of dietary iron or oral iron supplementation. 65 In addition, iron deficiency itself may reduce iron absorption from the gut. 66 More severe forms of EB are associated with chronic wound healing and infections, resulting in circulating cytokines which probably suppress erythropoiesis and reduce efficiency of iron use, producing anemia of inflammation.…”

Section: Anemia Key Points D Severe Multifactorial Anemia Is a Complimentioning

confidence: 99%

“…Newer and safer preparations of intravenous iron, including iron (III) hydroxide-sucrose complex 69 and ferric gluconate complex, 70 are probably preferable to iron dextran, 65 which is associated with a higher risk of anaphylaxis. Giving intravenous iron has been shown to improve hemoglobin levels in patients with EB, to increase general well being, and to reduce reliance on blood transfusion, 65,69 although patient numbers in these studies have been small. Intravenous access to administer iron supplementation, or pain associated with intramuscular iron dextran injections, may limit the usefulness of parenteral iron for some patients with EB.…”

Section: Anemia Key Points D Severe Multifactorial Anemia Is a Complimentioning

confidence: 99%

Extracutaneous manifestations and complications of inherited epidermolysis bullosa

Fine

Mellerio

2009

Journal of the American Academy of Dermatology

237

178

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“…Intractable inflammatory bowel disease, traumatic abdominal injury, and structural defects such as intestinal volvulus or intussusception, as well as necrotizing enterocolitis and typhlitis may necessitate intestinal resection, leading to a defect in iron absorption that may take years to manifest clinically. There are also rare gastrointestinal disorders leading to either malabsorption of iron or chronic blood loss or both, such as collagenous gastritis (Suskind et al, 2009), epidermolysis bullosa (Fridge & Vichinsky, 1998) and short gut syndromes.…”

Section: Discussionmentioning

confidence: 99%

A Case Based Approach to Severe Microcytic Anemia in Children

Freiberg¹

2012

New Advances in the Basic and Clinical Gastroenterology

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Correction of the anemia of epidermolysis bullosa with intravenous iron and erythropoietin

Cited by 31 publications

References 6 publications

Treatment of Iron Deficiency Anemia with Intravenous Iron Preparations

Treatment of Iron Deficiency Anemia with Intravenous Iron Preparations

Extracutaneous manifestations and complications of inherited epidermolysis bullosa

A Case Based Approach to Severe Microcytic Anemia in Children

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