Correction of retractile penis with subcutaneous soft silicone penile implant

Elist, James J.; Baniqued, Matthew R; Hosseini, Asieh; Wilson, Steven K.

doi:10.1038/s41443-019-0174-3

Cited by 10 publications

(2 citation statements)

References 13 publications

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“…Moreover, acquired penile deformities, such as Peyronie's disease and buried penis, that give the perception of a shorter penis have been shown to lower the self-esteem and self-confidence of many male patients. 3,4 This has led to increased demand in the clinical practices of urologists and sexual medicine specialists for cosmetic procedures to potentially enlarge the penis.…”

Section: Introductionmentioning

confidence: 99%

Removed: The Augmenta Implant: A Cadaver Model of a Novel Anatomic Subdermal Implant for Cosmetic Penile Enhancement

et al. 2021

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Introduction: There are limited options for cosmetic penile enhancement and the correction of structural penile deformities. Aim: We present the Augmenta, an innovative, technologically advanced subcutaneous elastomer-silicone cosmetic penile implant (CPI), as evaluated by objective structural changes in a cadaveric model. Methods: Five fresh male cadaver pelves were utilized in this preclinical setting. Placement of a subcutaneous elastomer-silicone CPI was performed via a penoscrotal approach. Penile circumference was measured at the base and distal shaft before and after implant placement. Penile length was measured from the pubic bone to the tip of the glans penis before and after implantation of Augmenta. Main Outcome Measure: Objective outcomes included changes in penile circumference and shaft length in both the flaccid and erect state, both before and after CPI placement. Results: In 5 cadaver models, implantation of the Augmenta CPI increased flaccid penile shaft base circumference from an average of 8.7 cm to 12.0 cm after implantation (39.1% increase, P < .001). Flaccid distal circumference increased from 7.3 cm to 10.3 cm (41.8% increase, P = .020). During the erect state, penile base circumference increased from an average of 12.5 cm to 13.7 cm (6.3% increase, P = .273), while distal erect circumference changed from an average of 11.3 cm to 12.4 cm (9.7% increase, P = .298). Nonstretched flaccid shaft length increased from an average of 12.1 cm to 14 cm (15.2% increase, P = .073). Clinical Implications: The Augmenta CPI could serve as alternative option for men seeking cosmetic penile enhancement. Strengths and Limitations: Limitations include a small number of cadavers which do not completely reproduce living physiologic function and the use of a single technical approach. However, a consistent and standardized surgical approach reduces operator-dependent outcomes. Another strength is the use of fresh human cadavers that most closely represent live models. Conclusion: In a cadaveric model, the Augmenta CPI demonstrates enhancements in penile girth in both the flaccid and erect state. The unique honeycomb technology, the embedded polyester mesh, and the antimicrobial hydrophilic coating of the Augmenta CPI may provide an advantage to currently available CPIs. Clinical trials will be needed to demonstrate both the safety and feasibility.

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Section: Introductionmentioning

confidence: 99%

Removed: The Augmenta Implant: A Cadaver Model of a Novel Anatomic Subdermal Implant for Cosmetic Penile Enhancement

et al. 2021

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“…Silicone rubber (SR) is one of the most well-researched materials in plastic and reconstructive surgery. Due to its light weight, easy processing, and biostability [1], SR has been used extensively in implantable medical devices throughout the body, such as the nose [2], breast [3], penis [4] and buttock [5]. Although SR does possess many desirable properties, its limited cell affinity and its lack of antibacterial activity lead to some undesirable consequences after remaining in vivo long-term, such as infection [6], malposition and capsular contracture [7].…”

Section: Introductionmentioning

confidence: 99%

Co-effects of C/Ag dual ion implantation on enhancing antibacterial ability and biocompatibility of silicone rubber

Zhou

Yan

et al. 2020

Biomed. Mater.

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Although silicone implants are the most popular choice around the world for breast augmentation, reconstruction, and revision, due to the poor antibacterial properties and limited biocompatibility of silicone rubber (SR), one of the major complications, capsule contracture, is a lingering problem. To overcome the two main shortcomings, a dual ion implantation technique was applied to modify the surface of SR with the basic skeleton element of organic matter, carbon (C) and the broad-spectrum bactericide, silver (Ag). We present surface characterization, toxicological effects, and evaluation of the mechanical, antibacterial and biocompatible properties of C and Ag co-implanted SR (C/Ag−SRs). After ion implantation, surface roughness and tensile strength of these new materials increased. Biotoxicity was fully assessed by in vitro experiments on human fibroblasts and in vivo experiments on rats, showing that the low-Ag groups met safety standards. Both the anti-bacterial adhesion and bactericidal abilities of C/Ag−SRs were superior to those of SR, which had few antibacterial activities, especially against Staphylococcus epidermidis. With respect to biocompatibility, the adhesion of fibroblasts was promoted, while their proliferation was moderately inhibited on ion-implanted surfaces. After subcutaneous implantation in rats for 7, 30, 90 and 180 d, the capsular thickness around C/Ag−SRs was significantly lower than that around the SR. Additionally, there was no difference in the inflammatory reaction after 7 d of retention in vivo between C/Ag−SRs and SR. The results demonstrate that C/Ag−SRs are desirable shell materials for breast implants.

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