Correction of metabolic acidosis and its effect on albumin in chronic hemodialysis patients

Brady, John Paul; Ja, Hasbargen

doi:10.1053/ajkd.1998.v31.pm9428449

Cited by 75 publications

(58 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There was no significant difference in the delivered dose of dialysis between both groups. Our results confirm the views of other investigators [7, 10]. …”

Section: Discussionsupporting

confidence: 94%

“…On the other hand, if the study had been limited to subjects with severe predialysis acidosis, perhaps a significant correlation might have been discovered. Based on the theory that metabolic acidosis stimulates protein catabolism and decreases protein synthesis, the effect of an increasing predialysis serum bicarbonate concentration on the nutrition of hemodialysis patients as measured by albumin for 16 weeks was investigated [10]. However, the increase in the serum bicarbonate concentration did not lead to a corresponding increase in the serum albumin concentration at the end of the study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Moderate Metabolic Acidosis and Its Effects on Serum Parameters in Hemodialysis Patients

Gao

Lew

Bosch³

2000

Nephron

View full text Add to dashboard Cite

We screened the laboratory data of 50 chronic hemodialysis patients selected randomly over a 21-month period to generate 158 data points which identified two groups: (1) those with a predialysis total CO₂ concentration less than or equal to 19 mEq/l (data A; n = 57) and (2) those with a predialysis total CO₂ concentration greater than 19 mEq/l (data B; n = 101). Then, both groups were compared for the following parameters: predialysis blood urea nitrogen (BUN), serum phosphorus, uric acid, creatinine, and albumin concentrations, Kt/V, urea reduction ratio, normalized protein catabolic rate, dry weight, ultrafiltration, blood flow and dialysis flow rates, duration of dialysis treatment, and blood pressure. Group data A had significantly higher predialysis BUN, phosphorus, and uric acid concentrations than group data B. There were significant inverse correlations between predialysis serum bicarbonate and predialysis BUN, phosphorus, and uric acid concentrations. Although it is not clear what the long term side effects of moderate metabolic acidosis are, we recommend its correction.

show abstract

“…There was no significant difference in the delivered dose of dialysis between both groups. Our results confirm the views of other investigators [7, 10]. …”

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Moderate Metabolic Acidosis and Its Effects on Serum Parameters in Hemodialysis Patients

Gao

Lew

Bosch³

2000

Nephron

View full text Add to dashboard Cite

show abstract

“…Although uremia and metabolic acidosis can lower serum albumin levels, 20,59 conclusive evidence demonstrating that reversing these pathologic states actually raises serum albumin levels is lacking. 60,61 …”

Section: Serum Albumin: a Clinical Index Of Illnessmentioning

confidence: 99%

Reassessment of Albumin as a Nutritional Marker in Kidney Disease

Friedman¹,

Fadem

2010

Journal of the American Society of Nephrology

309

245

View full text Add to dashboard Cite

“…Notably, this pathway mediates the anabolic and anticatabolic effects of IGF-1 and insulin (10), implicating acidosis as one cause of the resistance to both hormones seen in uremia (6,8). In humans with advanced CKD, treatment of severe acidosis has produced improvements in anthropometric measures of lean body mass in some (2,11,12) but not all (13)(14)(15) reports.…”

Section: Introductionmentioning

confidence: 99%

Effects of Oral Sodium Bicarbonate in Patients with CKD

Abramowitz

Melamed

Bauer³

et al. 2013

Clinical Journal of the American Society of Nephrology

121

106

View full text Add to dashboard Cite

SummaryBackground and objectives Metabolic acidosis contributes to muscle breakdown in patients with CKD, but whether its treatment improves functional outcomes is unknown. The choice of dose and tolerability of high doses remain unclear. In CKD patients with mild acidosis, this study evaluated the dose-response relationship of alkali with serum bicarbonate, its side effect profile, and its effect on muscle strength. Conclusions NaHCO 3 supplementation produces a dose-dependent increase in serum bicarbonate and improves lower extremity muscle strength after a short-term intervention in CKD patients with mild acidosis. Long-term studies are needed to determine if this finding translates into improved functional status.

show abstract

Correction of metabolic acidosis and its effect on albumin in chronic hemodialysis patients

Cited by 75 publications

References 12 publications

Moderate Metabolic Acidosis and Its Effects on Serum Parameters in Hemodialysis Patients

Moderate Metabolic Acidosis and Its Effects on Serum Parameters in Hemodialysis Patients

Reassessment of Albumin as a Nutritional Marker in Kidney Disease

Effects of Oral Sodium Bicarbonate in Patients with CKD

Contact Info

Product

Resources

About